A clinical study on the feasibility of autologous cord blood transfusion for anemia of prematurity

Khodabux, C. M.; Lindern, Jeannette S von; Hilten, J. A. van; Scherjon, Sicco A.; Walther, Frans J.; Brand, Anneke

doi:10.1111/j.1537-2995.2008.01747.x

Cited by 39 publications

(60 citation statements)

References 35 publications

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“…A few reports have used a modification of this practice for acute administration after birth, aimed at immediate volume expansion of ill and small neonates 82 94–100. Most of these reports describe processing and storing the fetal blood banking, in case a transfusion is needed in the subsequent days or weeks 82 96–99. Reports from Japan101 and Germany102 describe successful cord/placental blood transfusion for neonates with surgical problems.…”

Section: New Methods Aimed At Reducing the Need For Transfusionmentioning

confidence: 99%

Recent advances toward defining the benefits and risks of erythrocyte transfusions in neonates

Christensen

Ilstrup

2012

Arch Dis Child Fetal Neonatal Ed

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Section: New Methods Aimed At Reducing the Need For Transfusionmentioning

confidence: 99%

Recent advances toward defining the benefits and risks of erythrocyte transfusions in neonates

Christensen

Ilstrup

2012

Arch Dis Child Fetal Neonatal Ed

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“…In fact, in the past, other authors have described the clinical feasibility of cord blood for the therapy of anemic neonates, but only for autologous use [7,8,9,10,11]. …”

Section: Discussionmentioning

confidence: 99%

“…Several approaches have been explored to prevent or even to reduce the threshold and the frequency of RBC transfusions. Among these, umbilical cord blood (UCB) collection and processing to obtain RBC products for autologous transfusion have been extensively investigated [7,8,9,10,11,12]. The refinement of techniques of collection, processing and storage of UCB allowed the production of UCB-RBC units suitable for clinical use [13,14].…”

Section: Introductionmentioning

confidence: 99%

Allogeneic Umbilical Cord Blood Red Cell Concentrates: An Innovative Blood Product for Transfusion Therapy of Preterm Infants

Bianchi¹,

Giannantonio

Spartano³

et al. 2014

Neonatology

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Background: Preterm infants often receive blood transfusions early in life. In this setting, umbilical cord blood (UCB) might be safer than adult blood (A) with respect to infectious and immunologic threats. Objectives: To evaluate, as a first objective, the feasibility of fulfilling transfusion needs of preterm infants with allogeneic UCB red blood cell (RBC) concentrates and, as a secondary objective, to assess the safety of allogeneic cord blood transfusions. Methods: At the Neonatal Intensive Care Unit and the UNICATT Cord Blood Bank of ‘A. Gemelli' Hospital in Rome, a prospective study was carried out over a 1-year period, enrolling newborns with gestational age ≤30 weeks and/or birth weight ≤1,500 g requiring RBC transfusions within the first 28 days of life. At first transfusion, patients were assigned to receive UCB-RBCs or A-RBCs depending on the availability of ABO-Rh(D)-matched UCB-RBC units. The same regimen (UCB-RBC or A-RBC units) was thereafter maintained, unless ABO-Rh(D)-matched UCB-RBC units were not available. Results: Overall, 23 UCB-RBC units were transfused to 9 patients; the requests for UCB-RBC units were met in 45% of patients at the first transfusion and in 78% at the subsequent transfusions. At a median follow-up of 57 days (range 6-219), no acute or delayed transfusion-related adverse events occurred. Hematocrit gain after transfusion and time intervals between transfusions were similar in the UCB-RBC and A-RBC group, as well. Conclusions: Transfusing allogeneic UCB-RBC units in preterm infants appears a feasible and safe approach, although the transfusion needs of our study population were not completely covered. More data are necessary to validate this novel transfusion practice. © 2014 S. Karger AG, Basel

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“…The practice of transfusions of RBCs derived from umbilical cord blood to treat neonatal anemia has recently gained a lot of interest [26–35]. A number of studies have demonstrated that transfusions of autologous cord RBCs are both safe and effective in the treatment of anemic neonates [26–32].…”

Section: Introductionmentioning

confidence: 99%

Quality of Red Blood Cells Isolated from Umbilical Cord Blood Stored at Room Temperature

Zhurova

Akabutu²,

Acker

2012

Journal of Blood Transfusion

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Red blood cells (RBCs) from cord blood contain fetal hemoglobin that is predominant in newborns and, therefore, may be more appropriate for neonatal transfusions than currently transfused adult RBCs. Post-collection, cord blood can be stored at room temperature for several days before it is processed for stem cells isolation, with little known about how these conditions affect currently discarded RBCs. The present study examined the effect of the duration cord blood spent at room temperature and other cord blood characteristics on cord RBC quality. RBCs were tested immediately after their isolation from cord blood using a broad panel of quality assays. No significant decrease in cord RBC quality was observed during the first 65 hours of storage at room temperature. The ratio of cord blood to anticoagulant was associated with RBC quality and needs to be optimized in future. This knowledge will assist in future development of cord RBC transfusion product.

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A clinical study on the feasibility of autologous cord blood transfusion for anemia of prematurity

Abstract: Autologous RBCs derived from UCB could not replace 50 percent of allogeneic transfusions due to the low UCB volumes collected and subsequent low product availability.

Cited by 39 publications

References 35 publications

Recent advances toward defining the benefits and risks of erythrocyte transfusions in neonates

Recent advances toward defining the benefits and risks of erythrocyte transfusions in neonates

Allogeneic Umbilical Cord Blood Red Cell Concentrates: An Innovative Blood Product for Transfusion Therapy of Preterm Infants

Quality of Red Blood Cells Isolated from Umbilical Cord Blood Stored at Room Temperature

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