A clinical study on the effect of Triphaladi Kala Basti with Arjuna Punarnavadi Ghanavati in the management of essential hypertension

Abstract

Introduction: Hypertension, one of the grave conditions, accounts for 6% of deaths worldwide. In 2010 increased blood pressure was the cause of an estimated 9.4 million deaths. According to Ayurveda, systemic arterial hypertension can be considered as Tridoshaja condition with predominance of Vata and Pitta along with invovment of Rasa, Rakta and Meda . Basti Karma a medicated enema procedure is the best treatment for vitiated Vata Dosha and it regulates the movement of Vata Dosha Objectives: The present study was conducted to evaluate effect of Triphaladi Kala Basti procedure given along with Arjuna Punarnavadi Ghanavati in the management of essential hypertension. Materials and Methods: Fifteen patients who were diagnosed cases of essential hypertension as per the 7 th JNC and World Health Organization criteria for diagnosis of hypertension were treated with Triphaladi Basti followed by oral administration of Arjuna Punarnavadi Ghanavati . Results: Administration of Basti and Arjuna Punarnavadi Ghanavati were effective in reducing both systolic and diastolic blood pressure level which was highly significant ( P < 0.001). Conclusion: Triphaladi Kala Basti procedure along with oral administration of Arjuna Punarnavadi Ghanavati is moderatly effective in management of systemic arterial hypertension.

Development and Validation of a Stability Indicating HPTLC Method for Simultaneous Estimation of Telmisartan and Gallic Acid as per ICH Q1A (R2)

“…15,16 Gallic acid is predominantly present in fruits of individual plants Terminalia bellerica (Family-Combretaceae), Emblica Officinalis (Family-Euphorbiaceae), and Terminalia chebula (Family-Combretaceae), 17 which combinedly forms a very popular ayurvedic formulation called "Triphala," that has reported to be used as rejuvenator also effective in the prevention of hypertension. 18 This polyphenolic drug has a wide range of therapeutic windows and is considered safe at a higher concentration of 1000 mg/kg without any adverse or long-term side effects and non-toxic up to 5000 mg/kg. 19 As per literature study, AT1 receptor blocker, i.e., TEL, and anti-oxidant, i.e., GA, both have a common intersection area of cardiovascular disease curing potential.…”

A validated bioanalytical method for the simultaneous estimation of telmisartan and gallic acid in rat plasma samples by high‐performance thin‐layer chromatography–mass spectrometry: Application to an oral pharmacokinetic study

“…GA is a natural antioxidant found in various fruits and plant parts (Genwali et al, 2013). It serves as a primary component in traditional herbal formulations such as "Triphala" in Ayurvedic medicine, known for its rejuvenating properties and effectiveness in hypertension prevention (Hivale et al, 2018). This polyphenolic drug has a broad therapeutic range and is considered safe at doses as high as 1000 mg/kg without unpleasant or long-term side effects.…”