A Clinical Study on the Effect of Hwangryunhaedock-tang on Atopic Dermatitis

고민정,; 백정한,

doi:10.7778/jpkm.2012.26.4.051

Cited by 11 publications

(4 citation statements)

References 8 publications

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“…Orengedokuto also attenuates the inflammatory symptoms in mite-induced allergic dermatitis [9] and chemical allergen-induced contact dermatitis [10,11]. In addition to our report [8], berberine also exerts an anti-inflammatory effect in 12-O-tetradecanoylphorbol-13-acetate-induced dermatitis [12], allergic contact dermatitis [13,14] and fungus-induced dermatitis [5] in animals. These findings suggest that berberine (or Orengedokuto) is effective against inflammatory skin diseases.…”

Section: Tsugunobu Andoh and Tadamichi Shimizusupporting

confidence: 66%

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The Molecular Mechanisms underlying the Therapeutic Effect of Berberine in Inflammatory Skin Diseases

Andoh¹,

Shimizu²

2023

Asian J Complement Altern Med

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Clinical therapy of chronic inflammatory skin diseases such as atopic dermatitis is extremely difficult. Recently, the use of a number of traditional herbal medicines has been attempted to treat these skin diseases. Orengedokuto is a traditional herbal medicine consisting of four crude natural medicines, and in the field of dermatology, it is used to treat skin diseases accompanied by inflammation and pruritus. Our recent animal study showed that berberine, a major component of Orengedokuto, improves skin inflammation and itching in mice with atopy-like dermatitis. Furthermore, we identified EIF3F and MALT1 as factors involved in the suppression of cytokine production by berberine. In addition, berberine also activates AMP-activated protein kinase, which is involved in the expression of inflammatory and anti-inflammatory cytokines. In addition, berberine also attenuates epidermal hyperplasia though the inhibition of CDC6 expression. Taken together, these findings indicate that berberine improves inflammatory skin diseases by controlling gene expression related to both inflammation, anti-inflammation and keratinocyte hyperproliferation.

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Section: Tsugunobu Andoh and Tadamichi Shimizusupporting

confidence: 66%

“…In cases of atopic dermatitis with severe cutaneous inflammation and pruritus, Orengedokuto improves several symptoms [5,6].…”

Section: Therapeutic Effect Of Orengedokuto and Berberine In Inflamma...mentioning

confidence: 99%

The Molecular Mechanisms underlying the Therapeutic Effect of Berberine in Inflammatory Skin Diseases

Andoh¹,

Shimizu²

2023

Asian J Complement Altern Med

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“…HLJDT is known to possess therapeutic effects of clearing heat and detoxification in Chinese medicine practice and is widely used in skin diseases, such as eczema and AD ( Chen GR. et al, 2016 ; Ko and Baek, 2012 ; Yang et al, 2017 ). HLJDT is composed of four Chinese medicines, including Coptis chinensis Franch (Huanglian, whose rootstocks have medicinal use), Scutellaria baicalensis Georgi (Huangqin, whose root has medicinal use), Phellodendron amurense Rupr.…”

Section: Introductionmentioning

confidence: 99%

The Anti-Inflammatory and Anti-Pruritus Mechanisms of Huanglian Jiedu Decoction in the Treatment of Atopic Dermatitis

Chen

Zhang

et al. 2021

Front. Pharmacol.

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Atopic dermatitis (AD) is a common chronic skin disease driven by a T-cell-mediated immune response, with inflammation and pruritus being its main clinical manifestations. Huanglian Jiedu decoction (HLJDT), which is an ancient Chinese medicine herbal formula derived from Wai-Tai-Mi-Yao, is a potentially effective treatment for AD. We aimed to clarify the anti-inflammatory and anti-pruritus mechanisms of HLJDT in AD treatment. We performed immunohistochemistry, Western blotting, reverse transcriptase-polymerase chain reaction, Luminex-based direct multiplex immunoassay, enzyme-linked immunosorbent assays, and flow cytometry to address the abovementioned aims. HLJDT significantly reduced clinical symptoms and ear swelling in AD-like mice by inhibiting the production of cytokines [histamine, interleukin (IL)-3, IL-4, IL-5, IL-13, IL-17A, IL-31, and IL-33], substance P (SP), transient receptor potential cation channel subfamily V member 1 (TRPV-1), and gastrin-releasing peptide (GRP). Additionally, HLJDT significantly suppressed the protein expression levels and positive cell percentage of CD28, CD80, CD86, CD207, CD326, MHCII, and OX40 in the lymphoid nodes. Moreover, HLJDT significantly suppressed mRNA and protein expression of tyrosine–protein kinase (JAK1), histamine H4 receptor, and IL-4Rα, as well as the protein expression of GRP, SP, and TRPV-1 in the root ganglion. Our findings indicate that HLJDT can treat AD by regulating the antigen presentation function of dendritic cells, weakening T-lymphocyte activation, and subsequently exerting anti-inflammatory and anti-pruritus effects.

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“…HLJDD is a well-known written prescription for alleviating inflammatory conditions in the theory and practices of Chinese medicine because of the function of clearing body fire and removing heat toxicity [1] . Previous clinical studies have documented that HLJDD showed potent therapeutic effects on various inflammatory diseases including atopic dermatitis (AD) [2] , [3] , [4] . In addition, our previous work [5] also demonstrated that HLJDD has strong anti-inflammatory and anti-allergic activities in in vivo and in vitro models of AD.…”

Section: Introductionmentioning

confidence: 99%

Sub-chronic toxicity of the active fraction of a modified Huang-Lian-Jie-Du Decoction

Wang,

Yang,

Zhu

et al. 2024

Toxicology Reports

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A Clinical Study on the Effect of Hwangryunhaedock-tang on Atopic Dermatitis

Cited by 11 publications

References 8 publications

The Molecular Mechanisms underlying the Therapeutic Effect of Berberine in Inflammatory Skin Diseases

The Molecular Mechanisms underlying the Therapeutic Effect of Berberine in Inflammatory Skin Diseases

The Anti-Inflammatory and Anti-Pruritus Mechanisms of Huanglian Jiedu Decoction in the Treatment of Atopic Dermatitis

Sub-chronic toxicity of the active fraction of a modified Huang-Lian-Jie-Du Decoction

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