A clinical update on paediatric lupus

Spittal, Graeme; Lewandowski, Laura B.; Scott, Christiaan

doi:10.7196/samj.2015.v105i12.10341

Cited by 4 publications

(4 citation statements)

References 25 publications

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“…Diagnosis can be challenging where infections (such as TB) are often mimics of rheumatic diseases and diagnostic capabilities (including availability of autoantibody tests) are often limited in low resource settings [ 5 , 95 ]. Delayed diagnosis and access to specialist care in JSLE with worse clinical outcomes is widely reported across the world [ 79 , 88 , [96] , [97] , [98] ], often associated with more severe disease activity and organ damage at presentation [ 75 , 99 , 100 ]. Many of the innovations that have improved survival in HRIC remain unavailable in most of the world [ 77 ] and access to renal replacement therapy may be severely limited or non-existent [ 101 ].…”

Section: Impact Described Through Selected Msk Conditionsmentioning

confidence: 99%

Improving musculoskeletal health for children and young people – A ‘call to action’

Foster¹,

Scott

Tiderius

et al. 2020

Best Practice & Research Clinical Rheumatology

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This chapter describes the musculoskeletal (MSK) context in children and young people as an important contributor to the global non-communicable disease burden. Through selected MSK conditions, we describe the impact on patients, families and communities and highlight the challenges that need to be addressed. We focus on opportunities for better working together and describe exemplar initiatives to raise awareness, workforce capacity building, models of care and research agendas to have a greater global context.

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Section: Impact Described Through Selected Msk Conditionsmentioning

confidence: 99%

Improving musculoskeletal health for children and young people – A ‘call to action’

Foster¹,

Scott

Tiderius

et al. 2020

Best Practice & Research Clinical Rheumatology

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“…JSLE is a multisystem disease with serious, potentially life threatening organ involvement [21][22][23][24] and reported to be more common and severe in non-Caucasians with worse clinical outcomes [21,23,[25][26][27]; to our knowledge there are no population based prevalence studies in Asia or Africa. For the purpose of this study, we have assumed a prevalence of 10 in 100,000 based on the United States (US) Medicaid programme covering a multi-racial population [22]; we have not attempted to address variation in prevalence estimates by age, gender or ethnicity.…”

Section: Msk Conditionsmentioning

confidence: 97%

Global prevalence estimates of three chronic musculoskeletal conditions: club foot, juvenile idiopathic arthritis and juvenile systemic lupus erythematosus

et al. 2020

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Background: Musculoskeletal (MSK) conditions are a major source of morbidity and disability. There is a lack of global comparable data on the burden of MSK conditions in children and young people. Our aim was to estimate the global prevalence of three MSK conditions-Talipes Equinovarus (Clubfoot), Juvenile Idiopathic Arthritis (JIA) and Juvenile Systemic Lupus Erythematosus (JSLE). Methods: Using reported prevalence rates, age-stratified population data within the World Bank Data Bank in 2017 and United Nations country classification, we estimated the prevalence of these MSK conditions in < 5 year olds (clubfoot) and < 16 year olds (JIA and JSLE) across the world. Results: We estimated that in 2017, there were~675,061 < 5 year olds with clubfoot among 675,100,000 < 5 year olds,~2,069,246 < 16 year olds with JIA and~206,931 < 16 year olds with JSLE per 2,069,000,000 < 16 year olds, totalling~2,951,238 with one of these conditions. Disease prevalence was greatest in Asia (South Asia), followed by Africa, Americas, Europe and Oceania. Conclusions: An estimated 3 million children and young people globally are currently living with either clubfoot, JIA or JSLE; many in Asia and Africa. Further work is needed urgently to engage with global stakeholders to work together to improve access to effective care for the many who are affected and reduce the otherwise adverse lifelong impact on their health, quality of life and the impact on society.

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“…Pemeriksaan anti-dsDNA memiliki spesifitas tinggi dan sensitivitas hingga 70% dalam mendiagnosis LES sehingga sering dijadikan pemeriksaan penunjang diagnosis LES pada pasien. 17 Selain itu, penelitian oleh Kone dkk 18 juga menunjukkan bahwa 90% pasien anak LES memiliki peningkatan anti-dsDNA positif. Pemeriksaan ANA profile digunakan untuk mengukur kadar dan pola aktivitas antibodi pada darah dengan menggunakan prosedur imunofluorescence indirect dengan menggunakan sel Hep-2.…”

Section: Pembahasanunclassified

“…19 Pada saat anak terdiagnosis LES, seringkali hasil tes ANA menunjukkan hasil positif. 17 Hasil penelitian ini didukung oleh Muzayanah 20 pada tahun 2016 yang menemukan 91% anak dengan LES memiliki peningkatan kadar ANA di dalam darahnya. 20 Penelitian ini menunjukkan bahwa sebagian besar pasien anak LES di RSUD dr. Zainoel Abidin Banda Aceh memiliki kualitas hidup yang baik (67,6%).…”

Section: Pembahasanunclassified

Hubungan Lama Sakit dengan Kualitas Hidup pada Anak Lupus Eritematosus Sistemik di Rumah Sakit Umum Daerah dr. Zainoel Abidin Banda Aceh

Safri,

Roziana,

Salawati

et al. 2023

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Latar belakang. Lupus eritematosus sistemik pada anak memiliki karakteristik yang lebih berat dibandingkan pada masa dewasa, yaitu aktivitas penyakit yang lebih tinggi, derajat penyakit yang lebih berat, gangguan organ yang lebih berat, lebih agresif, keterlibatan ginjal dan sistem saraf lebih sering, dapat menyebabkan kerusakan yang lebih cepat, serta angka mortalitas yang lebih tinggi. Tujuan. Penelitian ini bertujuan untuk mengetahui hubungan lama sakit dengan kualitas hidup pada anak lupus eritematosus sistemik.Metode. Metode penelitian adalah analitik observasional dengan pendekatan cross-sectional pada 34 anak berusia 5-18 tahun dengan lupus eritematosus sistemik yang berobat di Poliklinik Anak Rumah Sakit Umum Daerah dr. Zainoel Abidin, Banda Aceh. Analisis menggunakan univariat dan bivariat dengan uji Spearman rank. Subjek penelitian mengisi kuesioner PedsQL 3.0 Rheumatology Module untuk menilai kualitas hidup. Hasil. Anak yang menderita LES dengan lama sakit ?5 tahun memiliki kualitas hidup yang baik yaitu 21 orang (67,6%) dan anak yang menderita LES >5 tahun juga memiliki kualitas hidup yang baik yaitu 2 orang (100%). Hasil uji korelasi Spearman rank pada interval kepercayaan 95% dan ? = 0,05 menunjukkan bahwa hubungan lama sakit dengan kualitas hidup menghasilkan p=0,328 dan nilai koefisien korelasi (r)=0,173.Kesimpulan. Tidak terdapat hubungan antara lama sakit dengan kualitas hidup pada anak lupus eritematosus sistemik.

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A clinical update on paediatric lupus

Cited by 4 publications

References 25 publications

Improving musculoskeletal health for children and young people – A ‘call to action’

Improving musculoskeletal health for children and young people – A ‘call to action’

Global prevalence estimates of three chronic musculoskeletal conditions: club foot, juvenile idiopathic arthritis and juvenile systemic lupus erythematosus

Hubungan Lama Sakit dengan Kualitas Hidup pada Anak Lupus Eritematosus Sistemik di Rumah Sakit Umum Daerah dr. Zainoel Abidin Banda Aceh

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