A clinicopathological and immunohistochemical study of gastric cancer with squamous cell carcinoma components: A clinically aggressive tumor

Saito, Shin; Hosoya, Yoshinori; Morishima, Kazue; Ui, Takashi; Higashi, Hidenori; Kurashina, Kentaro; Meguro, Yoshiyuki; Zuiki, Toru; Sata, Naohiro; Fujii, Hirofumi; Matsubara, Daisuke; Niki, Toshiro; Lefor, Alan Kawarai; Yasuda, Yoshikazu

doi:10.1111/j.1751-2980.2012.00610.x

Cited by 21 publications

(28 citation statements)

References 19 publications

(35 reference statements)

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“…Thirdly, the positive expression of CEA was found in SCC components 1 . Fourthly, identical levels of p53 gene was found in both components 6, 7 .…”

Section: Discussionmentioning

confidence: 77%

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Clinicopathological features and prognosis of gastric adenosquamous carcinoma

Feng

Zheng

et al. 2017

Sci Rep

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Data about primary gastric adenosquamous carcinoma (ASC) was limited due to rare incidence. Thus, the present study aims to investigate clinicopathological features and prognosis of gastric ASC. Cases of gastric ASC were obtained from our center and from case reports and series extracted from Medline. Clinicopathological features and prognosis of gastric ASC were analyzed and compared with gastric adenocarcinoma (AC) in our center. The commonest location was lower third (45.0%), followed by upper (26.2%) and middle third (24.2%). The median tumor size was 6 cm (0.8–17). The commonest differentiation status was well for both AC (44.4%) and SCC components (40.9%). Half of tumors (52.7%) were stage T4 and most patients (86.2%) suffered from lymph node metastasis (LNM). Tumor depth and TNM stage were risk factors for overall survival (OS) (both P < 0.05). The distribution of age, tumor size, tumor location, tumor depth, LNM and TNM stage were significantly different between gastric ASC and AC (all P < 0.05). The OS of gastric ASC was significantly worse than AC (P < 0.001), especially in stage III disease (P < 0.001). Gastric ASC differ significantly from AC with respect to clinicopathological features. The prognosis of gastric ASC was worse than AC.

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“…Thirdly, the positive expression of CEA was found in SCC components 1 . Fourthly, identical levels of p53 gene was found in both components 6, 7 .…”

Section: Discussionmentioning

confidence: 77%

“…The first hypothesis was supported by many researchers based on accumulating evidence. Firstly, most of the SCC components were located in deeper layer, in contrast to the AC components being located in the mucosal layer 6 . Secondly, an obvious transition area exists between AC and SCC components 1 .…”

Section: Discussionmentioning

confidence: 95%

Clinicopathological features and prognosis of gastric adenosquamous carcinoma

Feng

Zheng

et al. 2017

Sci Rep

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“…Several hypotheses for the origin of a squamous cell carcinoma component in ASC have been proposed: (1) squamous metaplasia of a pre-existing adenocarcinoma [1, 2, 5, 10]; (2) oncogenic transformation of metaplastic or ectopic squamous cells [4], and (3) stem cell differentiation into both adenocarcinoma and squamous cell carcinoma [11, 12]. Accumulating evidence supports the first hypothesis.…”

Section: Discussionmentioning

confidence: 99%

“…Adenosquamous carcinoma (ASC) of the stomach is a rare malignancy, accounting for <1% of all gastric carcinomas [1, 2, 3, 4], and is characterized by a mixture of two components: adenocarcinoma and squamous cell carcinoma. In the adenocarcinoma component, the differentiated type is more frequently observed than the poorly differentiated type [1, 2, 5], and the clinicopathological features of this tumor are dependent on the histological type of the adenocarcinoma component [5].…”

Section: Introductionmentioning

confidence: 99%

“…In the adenocarcinoma component, the differentiated type is more frequently observed than the poorly differentiated type [1, 2, 5], and the clinicopathological features of this tumor are dependent on the histological type of the adenocarcinoma component [5]. On the other hand, lymph node and liver metastases are frequently observed in ASC, and these metastases also tend to be found in advanced stages at diagnosis [1, 2, 3, 4, 5, 6, 7]; hence, this malignancy seems to a have a poorer prognosis than conventional gastric adenocarcinoma [1, 5]. …”

Section: Introductionmentioning

confidence: 99%

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Durable Response of Human Epidermal Growth Factor Receptor-2-Positive Gastric Adenosquamous Carcinoma to Trastuzumab-Based Chemotherapy

Kadowaki¹,

Yatabe

Nitta³

et al. 2014

Case Rep Oncol

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Here, we report a patient with gastric adenosquamous carcinoma (ASC) with human epidermal growth factor receptor-2 (HER2) overexpression who was successfully treated with trastuzumab-based chemotherapy. The patient was a 66-year-old man preoperatively diagnosed with gastric adenocarcinoma with no evidence of distant metastases. On histopathological examination, the curatively resected tumor was identified as ASC with mixed adenocarcinoma and squamous cell carcinoma components. Multiple liver metastases developed 2.5 months after surgery. Because immunohistochemical staining for HER2 was strong in both components, combination chemotherapy with capecitabine, cisplatin, and trastuzumab was initiated. A partial response was confirmed after 6 treatment cycles and PET and CT scans performed after 13 cycles revealed disease resolution with no uptake in the metastatic lesions. No evidence of disease progression has been observed 16 months after initial chemotherapy. This report suggests the potential utility of trastuzumab-based chemotherapy for HER2-positive gastric ASC.

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Adenosquamous Carcinoma of the Stomach and Review of the Literature

Chen

Huang

et al. 2015

Pathol. Oncol. Res.

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Adenosquamous carcinoma of the stomach is a very rare disease, consisting of less than 0.4 % of all stomach cancer. From 1991 to 2013, a total of 2800 patients received gastrectomy for gastric cancer at Taipei Veterans General hospital. Among them, seven patients (0.25 %) diagnosed as adenosquamous carcinoma were enrolled. The clinicopathologic characteristics and prognosis were analyzed. The mean age of the seven patients was 62.3 years-old. There were 5 males and 2 females. Six patients were stage III disease and one patient was stage IV disease. Four patients finally died of gastric cancer. Only one patient had no recurrence until death. Among the seven patients, adenocarcinoma component comprises the majority of the metastatic lymph node in 6 patients (85.7 %). The only one patient with major squamous cell carcinoma component in metastatic lymph node had no tumor recurrence till death. Adenosquamous carcinoma of stomach is a rare disease and is associated with a poor prognosis. The component of adenocarcinoma and squamous cell carcinoma in the metastatic lymph node may influence the prognosis.

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A clinicopathological and immunohistochemical study of gastric cancer with squamous cell carcinoma components: A clinically aggressive tumor

Cited by 21 publications

References 19 publications

Clinicopathological features and prognosis of gastric adenosquamous carcinoma

Clinicopathological features and prognosis of gastric adenosquamous carcinoma

Durable Response of Human Epidermal Growth Factor Receptor-2-Positive Gastric Adenosquamous Carcinoma to Trastuzumab-Based Chemotherapy

Adenosquamous Carcinoma of the Stomach and Review of the Literature

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