A miniaturized asymmetric coplanar strip fed with meander lines is developed for hexaband wireless applications. Multiband with compact size of the antenna is developed by using meander lines. The designed antenna is enhanced by an increased number of meander lines. The invented antenna is composed of three meander lines, it yields the antenna to excite 1.13, 2.35, 2.91, 3.46, 3.96, and 4.5 GHz, respectively. The prototype antenna is fed by ACS, which is printed on a 14 24 1.6 mm3 FR‐4 substrate and dielectric constant of Ɛr = 4.4. MATLAB tool is utilized in the ANN computation to amend the physical values of the antenna. The calibrated and simulated radiation attributes are identical with each other. The designed antenna provides distinguishing characteristics such as good reflection coefficient, impedance matching, and size miniaturization. It imparts empirical peak gains of 0.028 dBi at 1.14 GHz, 1.305 dBi at 2.35 GHz, 1.54 dBi at 2.86 GHz, 1.79 dBi at 3.43 GHz, 2.43 dBi at 3.96 GHz, and 2.58 dBi at 4.5 GHz, which is suitable for GSM/WLAN/WiMAX and C‐band wireless applications.