A Coating Material Containing Chlorhexidine and Lysozyme for Wound Treatment

Reshetov, I.; Yudanova, T. N.; Маторин, О. В.; Morozov, D. A.

doi:10.1023/b:phac.0000048441.64207.7c

Cited by 9 publications

(6 citation statements)

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“…Researchers found that 30 % LZ loaded CS-EDTA/PVA nanofiber mats were faster than bare-CS-EDTA/PVA and bare-CS-acetate/PVA nanofiber. The two main reasons proposed for this healing were (i) assists in the acceleration of the healing process by deactivating bacterial and depolymerizing the CS [110] and (ii) By products from CS depolymerisation such as EDTA and Nacetyl-d-glucosamine enhances the healing rate because of their antibacterial properties and aid in fibroblast proliferation [111].…”

Section: Wound Dressings With Chitosan and Synthetic Polymersmentioning

confidence: 99%

Chitosan: A Potential Therapeutic Dressing Material for Wound Healing

Archana

Dutta

2015

Springer Series on Polymer and Composite Materials

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A wide variety of polymers have been used over decades for the preparation of dressing materials for wound healing applications. But the dressing materials based on polysaccharides such as chitosan (CS) have received tremendous attention of the worldwide researchers as a consequence of its important properties like anti-infectional activity, biocompatibility, biodegradability, nontoxicity to mention a few. CS helps in every phase of wound healing such as acting as barrier against microbes, absorbing exudates, accelerates the infiltration of inflammatory cells like neutrophils and helps in healing without scar formation. A reason behind the popularity of CS is that not only it can easily be processed as gels, films, fibers, and scaffolds but also can be blended with natural as well as synthetic polymers to reduce price and improve properties like mechanical, wettability, gas permeability, and handling. Apart from natural and synthetic polymers, CS is also blended with nanoparticles and growth factors to which it shows better antibacterial activity and reduce time span for wound healing. The present chapter aims to focus on feasibility of combining natural polymers, synthetic polymers, nanoparticles, and growth factors with CS for the preparation of wound dressings as basic healthcare materials for regenerative medicine.

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Section: Wound Dressings With Chitosan and Synthetic Polymersmentioning

confidence: 99%

Chitosan: A Potential Therapeutic Dressing Material for Wound Healing

Archana

Dutta

2015

Springer Series on Polymer and Composite Materials

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“…Crosslinking agents are introduced into polymer matrices for various purposes. In particular, sodium tetraborate in a PVA-based film containing chlorhexidine bigluconate and lysozyme provides for optimum adsorption capacity (2 g/g), strength under wet medium conditions, and delayed drug release [89]. Such a film exhibits limited vapor permeability, and the exudate is discharged due to perforation of the dressing, which provides for the optimum humidity in the wound.…”

Section: Wound Dressings Possessing Antimicrobial Propertiesmentioning

confidence: 99%

“…It was established [84,85] that radiation sterilization at a dose of 25 kGy did not influence the antimicrobial properties of PVA-based films with iodine and katapol, but produced a 30% decrease in the antimicrobial activity of dioxidine (which is indicative of the low stability of this drug under irradiation). The biological activity of a PVA-based [89] film containing chlorhexidine bigluconate and lysozyme was practically completely retained upon radiation sterilization and subsequent long-term storage.…”

Section: Wound Dressings Possessing Antimicrobial Propertiesmentioning

confidence: 99%

Modern wound dressings: Manufacturing and properties

Yudanova

Reshetov

2006

Pharm Chem J

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The main directions of research aimed at the development of new wound dressings are considered. An important modern trend is the use of biocompatible natural and synthetic polymers and their compositions as the bases of wound dressings. The new products are free of the disadvantages of traditional textile materials, have flexible design, and possess combined properties (including antimicrobial activity), which expands their functions. Important advantages of new dressings are the atraumatic character, effective curative action, and reduced therapy time. 850091-150X/06/4002-0085

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“…LY loaded into chitosan nanofibers was also found to enhance wound healing due to its antibacterial properties and solubility in water and its synergistic antibacterial effects with EDTA 21 – 23 . Moreover, LY can promote the healing process, break down bacterial cell walls, and depolymerize chitosan to release N -acetyl- d -glucosamine 24 . LY was used in our previous study as the shell of microbubbles (MBs) and combined with US to reduce the dose and treatment duration and improve the prognosis of acne vulgaris 25 .…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-Mediated EGF-Coated-Microbubble Cavitation in Dressings for Wound-Healing Applications

Liao

Hung

Chen

et al. 2018

Sci Rep

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The feasibility of ultrasound (US) controlled cavitation for transdermal drug delivery (TDD) using gas-filled microbubbles (MBs) has been explored. However, liquid or gel-type MBs is not easy used for TDD. The present study investigated a new treatment model for evaluating the US-mediated liquid-type epidermal growth factor (EGF)-coated lysozyme microbubble (LYMB) cavitation in a wound dressing for enhancing wound healing. The maximum loading efficacy of EGF onto LYMBs was 19.40 ± 0.04%. In terms of the in vitro treatment efficacy, the growth of Staphylococcus aureus was inhibited by 97.50 ± 1.50% in the group with LYMBs exposed to 3 W/cm2 US. During 21 days in vivo wound healing experiments, the recovery rate during the first 6 days was significant higher in the group with EGF-LYMB dressings and US exposure (day 6: 54.28 ± 3.26%) than in the control group (day 6: 26.36 ± 3.34%) (p < 0.05). Our results show that the new model can significantly reduce the treatment duration during wound healing.

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A Coating Material Containing Chlorhexidine and Lysozyme for Wound Treatment

Cited by 9 publications

References 0 publications

Chitosan: A Potential Therapeutic Dressing Material for Wound Healing

Chitosan: A Potential Therapeutic Dressing Material for Wound Healing

Modern wound dressings: Manufacturing and properties

Ultrasound-Mediated EGF-Coated-Microbubble Cavitation in Dressings for Wound-Healing Applications

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