A Colon Targeted Delivery System for Resveratrol Enriching in pH Responsive-Model

Andishmand, Hashem; Hamishehkar, Hamed; Babazadeh, Afshin; Taghvimi, Arezou; Mohammadifar, Mohammad Amin; Tabibiazar, Mahnaz

doi:10.15171/ps.2017.07

Cited by 15 publications

(4 citation statements)

References 38 publications

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“…The antioxidant activity of the samples was determined by the DPPH method according to recent study (Peršurić et al, 2020 ) with some modifications. An alcoholic DPPH solution is reduced the existence of a hydrogen‐donating antioxidant (Andishmand et al, 2016 ; Soltanzadeh et al, 2022 ). DPPH reagent was obtained by dissolving 4‐mg DPPH in 100‐mL ethanol 96%.…”

Section: Methodsmentioning

confidence: 99%

Ultrasonication/dynamic maceration‐assisted extraction method as a novel combined approach for recovery of phenolic compounds from pomegranate peel

Andishmand,

Masoumi,

Torbati

et al. 2023

Food Science & Nutrition

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According to recent studies, pomegranate peel (PP) has the potential to be inverted from environmental pollutant waste to wealth due to possessing valuable phenolic compounds at a higher amount compared to edible parts. So far, different types of biological activities such as antimutagenic, antiproliferative, anti‐inflammatory, and chemo‐preventive properties were stated for pomegranate peel extract (PPE) according to chemical composition. In the present research, the probable intensifying effects of two extraction methods and optimum conditions for novel combined method of ultrasonication and dynamic maceration‐assisted extraction of PPE using response surface methodology (RSM) were determined. A Box–Behnken Design (BBD) was employed to optimize three extraction variables, including sonication time (X1), sonication temperature (X2), and stirring speed (X3) for the achievement of high extraction yield of the phenolic compounds and antioxidant activity. The optimized conditions to obtain maximum extraction efficiency were determined as X1 = 70 min, X2 = 61.8°C, and X3 = 1000 rpm. The experimental values were in line with the values anticipated by RSM models, which indicates the appropriateness of the applied quadratic model and the accomplishment of RSM in optimizing the extraction conditions. The results suggest that the extraction of PPE by mix of ultrasonication as a modern method and dynamic maceration as a conventional method could improve its bioactive extractability and the obtained values were higher than any of the methods used. In other words, these two methods together have intensifying effects in increasing extraction efficiency which could further be utilized in food and agricultural industry.

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Section: Methodsmentioning

confidence: 99%

Ultrasonication/dynamic maceration‐assisted extraction method as a novel combined approach for recovery of phenolic compounds from pomegranate peel

Andishmand,

Masoumi,

Torbati

et al. 2023

Food Science & Nutrition

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“…The stability, bioactivity, and bioavailability of active substances are essential to develop fortified foods (Andishmand et al, 2016). Food fortification is challenging because of the incompatibility of the fortifier with the food matrix, storage stability, and the possibility of changes in sensory characteristics (Faccinetto-Beltrán et al, 2021).…”

Section: Nanoe N C a Psu L At Ion Of Ac Tive Subs Tan Ce Smentioning

confidence: 99%

Fortification of chocolates with high‐value‐added plant‐based substances: Recent trends, current challenges, and future prospects

Abedini,

Dakhili,

Bazzaz

et al. 2023

Food Science & Nutrition

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High consumption of delicious foods, such as chocolates, is considered excellent snacks, capable of converting from health‐threatening to great functional foods. The fortification of chocolates with high‐value‐added plant‐based substances might improve their healthful effects, nutritional properties, and shelf life. Chocolate could be an effective carrier for plant‐based substances delivery, and it could be an effective vehicle to treat and reduce the indications of disease, such as obesity, overweight, hypertension, stress, cardiovascular failure, congestive heart failure, and diabetes. Referring to the recent studies in chocolate fortification with high‐value‐added plant‐based substances, it seems that the recent trends are toward its therapeutic effects against noncommunicable diseases. Despite the undeniable functional effects of fortified chocolates, there are some challenges in the fortification way of chocolates. In other words, their functional characteristics, such as rheological and sensory attributes, may undesirably change. It seems that encapsulation techniques, such as spray drying, antisolvent precipitation, nanoemulsification, and liposomal encapsulation, could almost overcome these challenges. Thus, several studies focused on designing and fabricating nanoscale delivery systems with the aim of chocolate fortification, which is discussed.

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“…However, for a range of therapeutics, food supplements and probiotics delivery to the colon is important. This is especially true for a range of inflammatory diseases of the GI-tract such as Crohn’s disease and Ulcerative colitis [ 1 , 2 , 3 , 4 , 5 , 6 ] but also for other diseases in the colon that would benefit from a local treatment including colon cancer [ 7 , 8 ], enteric nematodes [ 9 ] and enzyme replacement therapies [ 10 ]. Other areas of interest are colon delivery of proteins and peptides [ 11 , 12 ], probiotic bacteria [ 13 , 14 ] and microbiota replacement therapies [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Methods to Study Colon Release: State of the Art and An Outlook on New Strategies for Better In-Vitro Biorelevant Release Media

et al. 2019

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The primary focus of this review is a discussion regarding in vitro media for colon release, but we also give a brief overview of colon delivery and the colon microbiota as a baseline for this discussion. The large intestine is colonized by a vast number of bacteria, approximately 1012 per gram of intestinal content. The microbial community in the colon is complex and there is still much that is unknown about its composition and the activity of the microbiome. However, it is evident that this complex microbiota will affect the release from oral formulations targeting the colon. This includes the release of active drug substances, food supplements, and live microorganisms, such as probiotic bacteria and bacteria used for microbiota transplantations. Currently, there are no standardized colon release media, but researchers employ in vitro models representing the colon ranging from reasonable simple systems with adjusted pH with or without key enzymes to the use of fecal samples. In this review, we present the pros and cons for different existing in vitro models. Furthermore, we summarize the current knowledge of the colonic microbiota composition which is of importance to the fermentation capacity of carbohydrates and suggest a strategy to choose bacteria for a new more standardized in vitro dissolution medium for the colon.

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A Colon Targeted Delivery System for Resveratrol Enriching in pH Responsive-Model

Cited by 15 publications

References 38 publications

Ultrasonication/dynamic maceration‐assisted extraction method as a novel combined approach for recovery of phenolic compounds from pomegranate peel

Ultrasonication/dynamic maceration‐assisted extraction method as a novel combined approach for recovery of phenolic compounds from pomegranate peel

Fortification of chocolates with high‐value‐added plant‐based substances: Recent trends, current challenges, and future prospects

In Vitro Methods to Study Colon Release: State of the Art and An Outlook on New Strategies for Better In-Vitro Biorelevant Release Media

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