A combination therapy for androgenic alopecia based on quercetin and zinc/copper dual-doped mesoporous silica nanocomposite microneedle patch

Zhang, Zhaowenbin; Li, Wenbo; Di, Chang; Wei, Zhongqing; Wang, Endian; Yu, Jing; Xu, Yuze; Que, Yumei; Chen, Yanxin; Fan, Chen; Ma, Bing; Zhou, Yanling; Huan, Zhiguang; Yang, Chen; Guo, Feng; Chang, Jiang

doi:10.1016/j.bioactmat.2022.12.007

Cited by 38 publications

(23 citation statements)

References 80 publications

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“…46,51,60 On this ground, it has been reported that the induction of hair regrowth in AGA benefited from the resuscitation of dermal papillae with the surrounding vascular network by activating dermal papilla cells and vascular endothelial cells. 60,61 Previous studies confirmed that the hair cycle of the C57BL/6 mouse is divided into three phases: anagen phase, catagen phase, and telogen phase. 62 The murine skin always shows light pink during the telogen phase; then the skin turns dark gray or black when it enters the active anagen phase.…”

Section: Discussionmentioning

confidence: 95%

3D multicellular micropatterning biomaterials for hair regeneration and vascularization

Chen

et al. 2023

Mater. Horiz.

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Section: Discussionmentioning

confidence: 95%

3D multicellular micropatterning biomaterials for hair regeneration and vascularization

Chen

et al. 2023

Mater. Horiz.

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“…Researchers have invented a detachable microneedle patch, whose main component is chitosan lactate (CL) with adipose stem cell exosomes (EXO). CL and EXO synergistically promote hair regrowth and regulate the circulation of hair follicles 295 . Animal studies have shown that drug‐free microneedle patches significantly promote hair regrowth within 7 days, compared with the typically administered minoxidil at lower doses 296,297 .…”

Section: Other Systems Loaded With Stem Cells and Exosomesmentioning

confidence: 99%

Application of stem cells in regeneration medicine

Jin

et al. 2023

MedComm

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Regeneration is a complex process affected by many elements independent or combined, including inflammation, proliferation, and tissue remodeling. Stem cells is a class of primitive cells with the potentiality of differentiation, regenerate with self‐replication, multidirectional differentiation, and immunomodulatory functions. Stem cells and their cytokines not only inextricably linked to the regeneration of ectodermal and skin tissues, but also can be used for the treatment of a variety of chronic wounds. Stem cells can produce exosomes in a paracrine manner. Stem cell exosomes play an important role in tissue regeneration, repair, and accelerated wound healing, the biological properties of which are similar with stem cells, while stem cell exosomes are safer and more effective. Skin and bone tissues are critical organs in the body, which are essential for sustaining life activities. The weak repairing ability leads a pronounced impact on the quality of life of patients, which could be alleviated by stem cell exosomes treatment. However, there are obstacles that stem cells and stem cells exosomes trough skin for improved bioavailability. This paper summarizes the applications and mechanisms of stem cells and stem cells exosomes for skin and bone healing. We also propose new ways of utilizing stem cells and their exosomes through different nanoformulations, liposomes and nanoliposomes, polymer micelles, microspheres, hydrogels, and scaffold microneedles, to improve their use in tissue healing and regeneration.

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“…The nanocomposite dispersion was dried on a glass coverslip and subsequently mounted on a metal holder with an adhesive tape. A thin gold layer was coated onto the sample (QUORUM Q150 RES, UK) before the analysis (21).…”

Section: Morphological Characterization By Sem and Afmmentioning

confidence: 99%

Sodium alginate cross-linked hydroxypropyl methylcellulose/hydroxyapatite nano biomaterial mediated with zinc to promote bone tissue healing

Rudraradhya,

Teja,

Mukherjee

2023

Preprint

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The present study aimed to develop a composite material using sodium alginate and hydroxypropyl methylcellulose in combination with hydroxyapatite. The composite was doped with zinc and developed into a nanocomposite by using ionic gelation and solvent precipitation methods. The prepared nanocomposite was characterized by scanning electron microscopy, atomic force microscopy, dynamic light scattering, FTIR, and XRD studies. In vivo pharmacological studies were carried out to establish the bone targeting and bone tissue regeneration efficacy of the developed nanocomposite. The nanocomposite was checked for cell toxicity by performing an MTT assay using MG63 cell line and the molecular mechanism of targeting efficiency was assessed by in silico evaluation method. The results of the study confirmed the polymeric interlinking in the nanocomposite and the successful preparation of a composite material by using biodegradable excipients. SEM and AFM studies indicated that the nanocomposite was within the 80-200 nm size range. MTT assay indicated that the developed nanocomposite was not cytotoxic and well tolerated by the MG63 cell line. In vivo studies in validation with molecular docking evaluation suggested that the nanocomposite was effectively targeted to the bone as well as had osteogenesis properties by following a mechanism whereby it could effectively block Farnesyl Diphosphate Synthetase in the mevalonate pathway which is essential for inhibiting the osteoclastic activity and promoting osteogenesis.

show abstract

A combination therapy for androgenic alopecia based on quercetin and zinc/copper dual-doped mesoporous silica nanocomposite microneedle patch

Cited by 38 publications

References 80 publications

3D multicellular micropatterning biomaterials for hair regeneration and vascularization

3D multicellular micropatterning biomaterials for hair regeneration and vascularization

Application of stem cells in regeneration medicine

Sodium alginate cross-linked hydroxypropyl methylcellulose/hydroxyapatite nano biomaterial mediated with zinc to promote bone tissue healing

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