A combined DTI and resting state functional MRI study in patients with postherpetic neuralgia

Dai, Hui; Jiang, Chengcheng; Wu, Guanzuan; Huang, Renjun; Jin, Xiaohong; Zhang, Zhongshuai; Wang, Lina; Li, Yonggang

doi:10.1007/s11604-020-00926-4

Cited by 15 publications

(13 citation statements)

References 24 publications

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“…Moreover, we demonstrated that the strength of temporal coupling between the thalamus and DLPFC mediated the relationship from chronic pain to depression. In consistent with previous publications, in which thalamus showed stronger resting-state function connectivity with frontal cortex when the intensity of chronic pain increased, our observations also suggested that the deficits of the ascending pain modulation system were highly associated with the intensity of chronic pain and its emotional comorbidity of depression [45].…”

Section: Alterations Of Thalamus Connectivity and Itssupporting

confidence: 92%

Enhanced Temporal Coupling between Thalamus and Dorsolateral Prefrontal Cortex Mediates Chronic Low Back Pain and Depression

Song

Zhang

et al. 2021

Neural Plasticity

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Numerous neuroimaging studies have demonstrated that the brain plasticity is associated with chronic low back pain (cLBP). However, there is a lack of knowledge regarding the underlying mechanisms of thalamic pathways for chronic pain and psychological effects in cLBP caused by lumbar disc herniation (LDH). Combining psychophysics and magnetic resonance imaging (MRI), we investigated the structural and functional brain plasticity in 36 patients with LDH compared with 38 age- and gender-matched healthy controls. We found that (1) LDH patients had increased psychophysical disturbs (i.e., depression and anxiety), and depression (Beck-Depression Inventory, BDI) was found to be an outstanding significant factor to predict chronic pain (short form of the McGill Pain Questionnaire, SF-MPQ); (2) the LDH group showed significantly smaller fractional anisotropy values in the region of posterior corona radiate while gray matter volumes were comparable in both groups; (3) resting state functional connectivity analysis revealed that LDH patients exhibited increased temporal coupling between the thalamus and dorsolateral prefrontal cortex (DLPFC), which further mediate the relationship from chronic pain to depression. Our results emphasized that thalamic pathways underlying prefrontal cortex might play a key role in regulating chronic pain and depression of the pathophysiology of LDH.

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Section: Alterations Of Thalamus Connectivity and Itssupporting

confidence: 92%

Enhanced Temporal Coupling between Thalamus and Dorsolateral Prefrontal Cortex Mediates Chronic Low Back Pain and Depression

Song

Zhang

et al. 2021

Neural Plasticity

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“…Five studies mentioned a significant difference in the distribution of men and women (28,38,49,55,56), 8 did not present statistical results on potential differences in sex. Seven studies also matched for years of education (30,34,35,(57)(58)(59)(60), in addition to age and sex. The majority of studies was performed on a 3 Tesla scanner (n = 43), 10 studies used a 1.5 Tesla system.…”

Section: Risk Of Bias In Individual Studiesmentioning

confidence: 99%

Diffusion tensor imaging of white matter microstructure in chronic pain: a tract-based spatial statistics study and a systematic review

Koch

Bantel

et al. 2020

Preprint

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The pathophysiology of many chronic pain disorders is far from evident. MR imaging studies provided initial data indicating chronic pain might lead to changes in brain structure and function. These changes may contribute to cognitive and emotional impairment and maybe even to the chronification of pain. However, the evidence for pain-related changes in gray and white matter is inconclusive so far. Hence we investigated potential changes of white matter microstructure in 34 adults with chronic noncancer pain (> 1 year) and 34 sex- and age-matched healthy individuals using diffusion tensor imaging (DTI). Whole-brain tract-based spatial statistics (TBSS) analyses of fractional anisotropy, mode of diffusivity, mean diffusivity, axial diffusivity, and radial diffusivity did not show significant differences after correction for multiple comparisons. The volumes of subdivisons of the corpus callosum were not significantly different either. We also performed a systematic review of the existing literature on white matter microstructure in patients with chronic pain following PRISMA guidelines. We identified 53 eligible studies on DTI in chronic pain. These studies demonstrated conflicting results regarding the direction and location of white matter changes across all diagnoses and within major diagnostic subcategories. We propose that two factors primarily contribute to this low reproducibility, small sample size and the use of potentially unreliable DTI parameters derived from the single-tensor model.

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“…Previous studies have shown that the brain structure is mainly composed of the medulla and cortex. Previous studies on the brain medulla mainly focused on diffusion tensor imaging (DTI), 3 , 4 which found that the microstructural integrity of white matter in multiple brain regions of PHN patients changed. Previous studies on the cerebral cortex of herpes zoster mainly included diffusion kurtosis imaging (DKI) and voxel-based morphometry (VBM).…”

Section: Introductionmentioning

confidence: 99%

MRI Study of Cerebral Cortical Thickness in Patients with Herpes Zoster and Postherpetic Neuralgia

Liu¹,

Gu²,

Liu³

et al. 2022

JPR

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Objective To measure the changes in cerebral cortical thickness in patients with herpes zoster (HZ) and postherpetic neuralgia (PHN) by surface-based morphometry (SBM) and further estimate its correlation with clinical scores. Materials and Methods Twenty-nine HZ patients, 30 PHN patients and 30 well-matched healthy controls (HCs) were included. Magnetic resonance imaging (MRI) data from all subjects were collected and then analyzed by SBM. The changes in cortical thickness among the HZ, PHN and HC groups were analyzed by ANOVA and correlated with clinical scores. Results The thickness of the bilateral primary visual cortex (V1, V2) and right primary visual cortex (V3), left somatosensory cortex (L3A), right anterior cingulate gyrus and medial prefrontal cortex (RS32) increased in PHN group, and the thickness the left insular and frontal opercular cortex (LFOP4), left motor cortex (L3B), and right superior temporal visual cortex (RSTV) were decreased in the HZ and PHN groups compared to the HC group. The thickness measurements of RS32, LFOP4, and (L3B) in HZ and PHN patients were correlated with the duration of disease. In HZ and PHN patients, the Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) scores were significantly positively correlated. Conclusion Changes in cortical thickness in the areas related to sensory, motor, and cognitive/emotional changes in patients with PHN affect the neuroplasticity process of the brain, which may be the reason for the transformation of HZ into PHN and provide a possible explanation for the neuropathological mechanism of pain persistence in PHN patients.

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A combined DTI and resting state functional MRI study in patients with postherpetic neuralgia

Cited by 15 publications

References 24 publications

Enhanced Temporal Coupling between Thalamus and Dorsolateral Prefrontal Cortex Mediates Chronic Low Back Pain and Depression

Enhanced Temporal Coupling between Thalamus and Dorsolateral Prefrontal Cortex Mediates Chronic Low Back Pain and Depression

Diffusion tensor imaging of white matter microstructure in chronic pain: a tract-based spatial statistics study and a systematic review

MRI Study of Cerebral Cortical Thickness in Patients with Herpes Zoster and Postherpetic Neuralgia

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