A combined iron and thyroid hormone protocol suppresses ischemia–reperfusion injury in rat livers

Pedemonte, J.; Vargas, Romina; Castillo, Valentina; Hodali, T.; Gutiérrez, Soraya; Tapia, Gladys; Castillo, Iván; Videla, Luis A.; Fernández, Virgínia

doi:10.1039/c4ra15863f

Cited by 1 publication

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References 42 publications

(48 reference statements)

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“…PCA (Figure S6B, Supporting Information), Spearman analysis (Figure S6C, Supporting Information) and heat map (Figure S6D, Supporting Information) suggested that compared to the group receiving oral L‐T 4 treatment (L‐T 4 mice), the organs, particularly the hearts and livers of ST mice, exhibited a functioning state closer to that of normal animals (N mice). We examined the expression of important T 3 ‐regulated genes ( THRSP1 , [ 35 ] Dio1 , [ 36 ] ME1 , [ 37 ] and Myh6 [ 38 ] ), as well as genes associated with T 3 malfunctions, ( Per3 [ 39 ] and Ciart [ 40 ] related to circadian rhythm, Trib3 [ 41 ] related to glucose regulation, Gclc [ 42 ] related to glutathione synthesis, Cyp2c69 and Cyp21a1 related to lipid metabolism, [ 43 ] Esm1 and Aplnr [ 44 ] related to angiogenesis) using qRT‐PCR (Figure S7A, Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

Regeneration of Thyroid Glands in the Spleen Restores Homeostasis in Thyroidectomy Mice

Tian,

Yin,

et al. 2023

Advanced Science

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Surgical removal of the thyroid gland (TG) for treating thyroid disorders leaves the patients on lifelong hormone replacement that partially compensates the physiological needs, but regenerating TG is challenging. Here, an approach is reported to regenerate TG within the spleen for fully restoring the thyroid's functions in mice, by transplanting thyroid tissue blocks to the spleen. Within 48 h, the transplanted tissue efficiently revascularizes, forming thyroid follicles similar to the native gland after 4 weeks. Structurally, the ectopically generated thyroid integrates with the surrounding splenic tissue while maintaining its integrity, separate from the lymphatic tissue. Functionally, it fully restores the native functions of the TG in hormone regulation in response to physiological stimuli, outperforming the established method of oral levothyroxine therapy in maintaining systemic homeostasis. The study demonstrates the full restoration of thyroid functions post‐thyroidectomy by intrasplenic TG regeneration, providing fresh insights for designing novel therapies for thyroid‐related disorders.

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Section: Resultsmentioning

confidence: 99%

Regeneration of Thyroid Glands in the Spleen Restores Homeostasis in Thyroidectomy Mice

Tian,

Yin,

et al. 2023

Advanced Science

View full text Add to dashboard Cite

show abstract

A combined iron and thyroid hormone protocol suppresses ischemia–reperfusion injury in rat livers

Abstract: Liver preconditioning (PC) against ischemia–reperfusion (IR) injury is attained by iron (Fe) or thyroid hormone (T3) administration.

Cited by 1 publication

References 42 publications

Regeneration of Thyroid Glands in the Spleen Restores Homeostasis in Thyroidectomy Mice

Regeneration of Thyroid Glands in the Spleen Restores Homeostasis in Thyroidectomy Mice

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