A combined pattern of movement disorders resulting from posterolateral thalamic lesions of a vascular nature: A syndrome with clinico-radiologic correlation

Lera, G.; Scipioni, Osualdo; García, S. Beltrán; Cammarota, Angel; Fischbein, Gustavo; Gershanik, Oscar S.

doi:10.1002/1531-8257(200001)15:1<120::aid-mds1018>3.0.co;2-v

Cited by 26 publications

(23 citation statements)

References 28 publications

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“…The thalamus is a relay centre between subcortical areas and the cerebral cortex, and it has multiple sensory and motor functions, along with the regulation of awareness, attention, memory and language [43]–[45]. Lesions confined to the thalamus have been associated with asterixis [46], and hemorrhages restricted to the region lateralis of the thalamus lead to a cheiro-oral syndrome [47] or choreiform and dystonic movements associated with myorhythmia [48]. Lesions of both thalamus and basal ganglia are related to dystonia [49].…”

Section: Discussionmentioning

confidence: 99%

3D Texture Analysis Reveals Imperceptible MRI Textural Alterations in the Thalamus and Putamen in Progressive Myoclonic Epilepsy Type 1, EPM1

et al. 2013

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Progressive myoclonic epilepsy type 1 (EPM1) is an autosomal recessively inherited neurodegenerative disorder characterized by young onset age, myoclonus and tonic-clonic epileptic seizures. At the time of diagnosis, the visual assessment of the brain MRI is usually normal, with no major changes found later. Therefore, we utilized texture analysis (TA) to characterize and classify the underlying properties of the affected brain tissue by means of 3D texture features. Sixteen genetically verified patients with EPM1 and 16 healthy controls were included in the study. TA was performed upon 3D volumes of interest that were placed bilaterally in the thalamus, amygdala, hippocampus, caudate nucleus and putamen. Compared to the healthy controls, EPM1 patients had significant textural differences especially in the thalamus and right putamen. The most significantly differing texture features included parameters that measure the complexity and heterogeneity of the tissue, such as the co-occurrence matrix-based entropy and angular second moment, and also the run-length matrix-based parameters of gray-level non-uniformity, short run emphasis and long run emphasis. This study demonstrates the usability of 3D TA for extracting additional information from MR images. Textural alterations which suggest complex, coarse and heterogeneous appearance were found bilaterally in the thalamus, supporting the previous literature on thalamic pathology in EPM1. The observed putamenal involvement is a novel finding. Our results encourage further studies on the clinical applications, feasibility, reproducibility and reliability of 3D TA.

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Section: Discussionmentioning

confidence: 99%

3D Texture Analysis Reveals Imperceptible MRI Textural Alterations in the Thalamus and Putamen in Progressive Myoclonic Epilepsy Type 1, EPM1

et al. 2013

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“…In general, these involuntary movement disorders after ischemic stroke are regarded as really uncommon neurological manifestations [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15]. D'Olhaberriague et al [13] reported that in their study 9 patients with movement disorders were identified among 908 ischemic stroke cases (1%).…”

Section: Discussionmentioning

confidence: 99%

“…Thalamic lacunar infarction resulting from arteriosclerotic thrombosis of a single penetrating artery gives rise to a variety of clinical syndromes such as pure sensory stroke, ataxic hemiparesis, painful ataxic hemiparesis, hypesthetic ataxic hemiparesis and rarely involuntary movements including tremor, asterixis, athetosis, dystonia, pseudochoreoathetosis and chorea [1, 2, 3, 4, 5, 6, 7, 8, 9]. In many previous reports, various forms of hyperkinetic or hypokinetic disorders have been described following focal cerebrovascular lesions [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12].…”

Section: Introductionmentioning

confidence: 99%

“…In many previous reports, various forms of hyperkinetic or hypokinetic disorders have been described following focal cerebrovascular lesions [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12]. However, involuntary movement disorders are very uncommon clinical manifestations in the acute phase of ischemic stroke, and particularly hemi-chorea is regarded as one of the rarest neurological symptoms [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15]. Therefore, the mechanism responsible for hemi-chorea following a cerebrovascular lesion is not yet completely understood [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15].…”

Section: Introductionmentioning

confidence: 99%

“…The patient had no other neurological symptoms. This report includes a discussion of the anatomical basis for the clinico-radiological correlation and the pathophysiological mechanism of this rare condition, referring to previous literature [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15]. …”

Section: Introductionmentioning

confidence: 99%

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Pure Hemi-Chorea Resulting from an Acute Phase of Contralateral Thalamic Lacunar Infarction: A Case Report

et al. 2012

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Background: Thalamic lesions give rise to a variety of clinical syndromes such as pure sensory stroke, ataxic hemiparesis, and rarely involuntary movements including chorea. Generally and classically, lacunar infarction in the subthalamic nucleus has been regarded as the lesion mainly responsible for hemi-chorea and hemi-ballismus, on the basis of previous anatomical studies. Case Presentation: This report describes the case of an 81-year-old man who developed sudden-onset pure hemi-chorea in the right limbs resulting from an acute phase of left thalamic lacunar infarction detected on a diffusion-weighted image (DWI) in an MRI study. The patient had no other neurological symptoms such as ataxic hemiparesis and sensory disturbance. A single-photon emission computed tomography (SPECT) study using the ^99mTc-ECD Patlak plot method demonstrated significant perfusional asymmetry between the right and left thalami (p = 0.0035), consistent with the left thalamic lesion on DWI. Conclusion: It is speculated that this perfusional asymmetry, in particular the hypoperfusion in the left thalamus, detected by SPECT might play the most important role in the contralateral pure hemi-chorea as a rare neurological manifestation in this case.

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Unusual tremor associated with a posterolateral thalamic lesion in a drummer

O’Sullivan

Brown²,

Lees³

2001

Mov Disord.

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A combined pattern of movement disorders resulting from posterolateral thalamic lesions of a vascular nature: A syndrome with clinico-radiologic correlation

Cited by 26 publications

References 28 publications

3D Texture Analysis Reveals Imperceptible MRI Textural Alterations in the Thalamus and Putamen in Progressive Myoclonic Epilepsy Type 1, EPM1

3D Texture Analysis Reveals Imperceptible MRI Textural Alterations in the Thalamus and Putamen in Progressive Myoclonic Epilepsy Type 1, EPM1

Pure Hemi-Chorea Resulting from an Acute Phase of Contralateral Thalamic Lacunar Infarction: A Case Report

Unusual tremor associated with a posterolateral thalamic lesion in a drummer

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