A combined phase I and II open label study on the effects of a seaweed extract nutrient complex on osteoarthritis

Myers, Stephen P; O'Connor, Joan; Fitton, J. Helen; Brooks, Lyndon O; Rolfe, Margaret; Connellan, Paul; Wohlmuth, Hans; Cheras, Phillip A; Morris, Carol A.

doi:10.2147/btt.s8354

Cited by 61 publications

(76 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These polymers show a variety of biological activities in both plant and animal systems and are involved in host defense mechanisms (Ideo et al 2009;Li et al 2008;Myers et al 2010;Nakayasu et al 2009;Wang et al 2009a). Of particular interest in agriculture are those that elicit defensive responses resulting in protection against pathogens or insect damage.…”

Section: Polymersmentioning

confidence: 99%

See 1 more Smart Citation

Seaweed extract stimuli in plant science and agriculture

2010

View full text Add to dashboard Cite

Both micro-and macroalgae have long been used to augment plant productivity and food production in various regions of the world through their beneficial effects when applied to soils. Interactions of algae with the soil community undoubtedly are complex and benefits are dependent on the crop and the local environmental conditions. This has resulted in much speculation as to mechanisms involved as well as the validity of the results reported. It is now 60 years since the first commercial seaweed extract was manufactured for agricultural use. These aqueous extracts allowed for the first time the direct application of soluble seaweed constituents to specific plant organs such as leaves and roots. The earlier concept that benefits of seaweeds and their extracts were due mainly to their manurial value or to their micronutrient suites is no longer tenable. Seaweeds likewise have been used for millennia as fodder supplements to improve animal nutrition and productivity. Recent research is focusing on their mode of action, specific health benefits, and the mechanisms of action in animals. Improved analytical techniques and instrumentation coupled with the use of molecular genetic tools are establishing that seaweed extracts can modify plant and animal responses at a fundamental level. It therefore seems appropriate to review key developments over the years and to remark on novel findings. A new and exciting vista has opened for seaweed extracts in both plant and animal applications.

show abstract

Section: Polymersmentioning

confidence: 99%

“…The hypocholesterolemic activity of brown seaweed fractions when fed to vertebrates has long been known (Tsuchiya 1969). Broad applications are currently being considered for functional ingredients from both micro-and macroalgae (Plaza et al 2009;Myers et al 2010).…”

Section: Seaweeds and Extracts In Animal Dietsmentioning

confidence: 99%

Seaweed extract stimuli in plant science and agriculture

2010

View full text Add to dashboard Cite

show abstract

“…With regard to arthritis, several recent studies already suggest a role for fucoidan in addressing the symptoms of arthritis. 25,26 However, very few studies have examined the precise role of fucoidans in modulating inflammatory processes and providing protection against OA.…”

Section: Introductionmentioning

confidence: 99%

Fucoidan Prevents the Progression of Osteoarthritis in Rats

Lee

Park

Chung

et al. 2015

Journal of Medicinal Food

View full text Add to dashboard Cite

This study investigated the effects of fucoidan (extract from Hizikia fusiforme) on symptoms and inflammatory cytokine activation in rats with monosodium iodoacetate (MIA)-induced osteoarthritis (OA). Forty male SD rats were divided into five groups, including normal, negative control (MIA), positive control (Lyprinol), and two experimental groups treated with 50 or 100 mg/kg fucoidan. Weight-bearing assessments were done after MIA injection into the right knee to induce OA. After 14 days of treatment, microcomputed tomographic (micro-CT) images were made of rat knee joints, and then animals were sacrificed for joint histology and inflammatory cytokine level assessments. MIA injection successfully induced OA by causing 40% weight-bearing imbalance, severe bone loss and cartilage degeneration, and markedly increased cytokine levels. However, fucoidan groups showed over 45% of imbalance and no articular cartilage surface lesions or change in subchondral trabecular bones in Micro-CT images. Histological analysis revealed that cartilage morphology and cell counts were also normal in the 100 mg/kg fucoidan group. In addition, the 100 mg/kg fucoidan groups exhibited lower serum tumor necrosis factor alpha (TNF-α) (30%), interleukin 1 beta (IL-1β) (48%), and matrix metalloproteinase-1 (MMP-1) (65%) compared to the MIA groups. These results suggest that administration of fucoidan prevents the progression of OA in a MIA-induced OA rat model.

show abstract

“…The sulfated polysaccharide from the brown algae Laminaria japonica, sulfated polymannuroguluronate has been reported to exhibit neuroprotective effect by decreasing apoptosis in PC12 neuronal cells, in vitro [47]. Fucoidan from marine algae such as Fucus vesiculosis, Macrocystis pyrifera and Laminaria japonica has been reported to suppress cellular infiltration of joints [48], neutrophil migration [49] and post-operative pain with no toxicity [50]. Α 1, 4 D glucan from the blue mussel Mytilus coruscus has been reported to exhibit antioxidant activity by preventing liver injury of mice by lowering the levels of serum ALT, AST and hepatic MDA [51].…”

Section: Marine Carbohydrate Based Drugs For Ndmentioning

confidence: 99%

Marine Carbohydrate Based Therapeutics for Alzheimer Disease-Mini Review

Manig¹,

Ramachandran²,

Saravanan³

2015

J Neurol Neurosci

View full text Add to dashboard Cite

Neurological disorders occur due to recognition of neurological repairs and resources are indirectly scarce, especially in low income and developing countries. They are disorders of the central nervous system and common cause of physiological and economic burden worldwide. Alzheimer's disease (AD) and other dementias is one of the progressive neurodegenerative disorders which causes memory loss and cognitive impairment due to aggregation of misfolded proteins and neurofibrillar tangles in brain. The failure of the conventional drugs to decline disease progression accompanied with numerous adverse effects has forced the researchers to look for efficient drug candidates from alternate natural resources. The marine reservoir with its large biodiversity and untapped resource potential holds numerous molecules of biomedical and clinical importance. In this review, we hypothesize the utilization of the sulfated polysaccharides as glycobased mimetics, leading to the prevention of aggregation of plaques and protein tangles. With further screening and validation, the carbohydrates from the marine sources, thus hold immense potentials to function as alternative therapeutic agent against neurological disorders.

show abstract

A combined phase I and II open label study on the effects of a seaweed extract nutrient complex on osteoarthritis

Cited by 61 publications

References 30 publications

Seaweed extract stimuli in plant science and agriculture

Seaweed extract stimuli in plant science and agriculture

Fucoidan Prevents the Progression of Osteoarthritis in Rats

Marine Carbohydrate Based Therapeutics for Alzheimer Disease-Mini Review

Contact Info

Product

Resources

About