A common missense single nucleotide polymorphism in the E-selectin gene is significantly associated with essential hypertension in the Han population but only weakly associated in the Uygur population

Wang, Zhong; Xu, Yujun; Chen, Shaoze; Wang, Li; Ding, Hu; Lu, Guilin; Wang, Daowen; Zhai, Zhensheng; Duan, Juncang; Wangqiang, Zhang

doi:10.1038/hr.2011.204

Cited by 16 publications

(15 citation statements)

References 22 publications

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“…A total of eleven studies met the inclusion criteria. Because one article [16] contained three ethnic groups (Han, Uygur and Kazak) with three independent results, we analyzed it as three separated cohorts for each polymorphism. Ten studies (twelve cohorts) evaluated A561C polymorphism and EH risk, including 2,813 cases and 2,817 controls.…”

Section: Resultsmentioning

confidence: 99%

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E-Selectin Gene Polymorphisms and Essential Hypertension in Asian Population: An Updated Meta-Analysis

et al. 2014

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ObjectiveEpidemiological studies have shown that E-selectin gene polymorphisms (A561C and C1839T) may be associated with essential hypertension (EH), but the results are conflicting in different ethnic populations. Thus, we performed this meta-analysis to investigate a more authentic association between E-selectin gene polymorphisms and the risk of EH.MethodsWe searched the relevant studies for the present meta-analysis from the following electronic databases: PubMed, Embase, Cochrane Library, Google Scholar, Web of Science, Wanfang Data, and China National Knowledge Infrastructure (CNKI). Odds ratios (OR) with 95% confidence interval (CI) were used to evaluate the strength of the association between E-selectin gene polymorphisms and EH susceptibility. The pooled ORs were performed for dominant model, allelic model and recessive model. The publication bias was examined by Begg’s funnel plots and Egger’s test.ResultsA total of eleven studies met the inclusion criteria. All studies came from Asians. Ten studies (12 cohorts) evaluated the A561C polymorphism and EH risk, including 2,813 cases and 2,817 controls. The pooled OR was 2.280 (95%CI: 1.893–2.748, P<0.001) in dominant model, 5.284 (95%CI: 2.679–10.420, P<0.001) in recessive model and 2.359 (95%CI: 1.981–2.808, P = 0.001) in allelic model. Four studies (six cohorts) evaluated C1839T polymorphism and EH risk, including 1,700 cases and 1,681 controls. The pooled OR was 0.785 (95%CI: 0.627–0.983, P = 0.035) in dominant model, 1.250 (95%CI: 0.336–4.652, P = 0.739) in recessive model and 0.805 (95%CI: 0.649–0.999, P = 0.049) in allelic model.ConclusionThe current meta-analysis concludes that the C allele of E-selectin A561C gene polymorphism might increase the EH risk in Asian population, whereas the T allele of E-selectin C1839T gene polymorphism might decrease the EH risk.

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Section: Resultsmentioning

confidence: 99%

“…In Xinjiang area, Wang et al . [16] investigated the relationship between E-selectin gene polymorphisms and EH in Han, Kazakh and Uygur populations. They also found there was no significant association between C1839T polymorphism and EH risk in these populations.…”

Section: Discussionmentioning

confidence: 99%

E-Selectin Gene Polymorphisms and Essential Hypertension in Asian Population: An Updated Meta-Analysis

et al. 2014

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“…This discrepancy could be attributed to genetic heterogeneity among these different populations. Some variants may be poor markers for hypertension because of differences in the linkage-disequilibrium structure in ethnic backgrounds (Wang et al, 2012). Differences in gene-gene or gene-environment interactions in the development of hypertension in these ethnicities may also contribute to the discrepancy.…”

Section: Discussionmentioning

confidence: 99%

CAMK4 gene variation is associated with hypertension in a Uygur population

Wang

et al. 2016

Genet. Mol. Res.

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“…Furthermore, Faruque et al (10) assessed the association between SELE polymorphisms and both hypertension and blood pressure in African Americans and found two SNPs (rs3917420 and rs5361) in the SELE gene associated with SBP. Moreover, Wang et al (25) explored the association between two common variants in the E-selectin gene (rs5361A/C and rs5355C/T) and EH in the Uygur, Kazakh and Han populations in the Xinjiang area. These results indicated that the common variant rs5361 is strongly associated with EH in Han individuals and weakly associated in Uygur individuals.…”

Section: Discussionmentioning

confidence: 99%

Associations SELE Gene Haplotype Variant and Hypertension in Mongolian and Han Populations

Zhao

Liu

et al. 2015

Intern. Med.

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Genetic variation is thought to contribute to the etiology of hypertension, and E-selectin is a candidate essential hypertension-associated gene. Objective In this study, we attempted to test the hypothesis that subtle haplotype variants of SELE genes may be sources of essential hypertension in Mongolian and Han populations. Materials A total of 429 unrelated Mongolian herdsmen and 416 Han farmers were enrolled, including 212 Mongolian essential hypertension (EH) patients, 217 Mongolian normotensives (controls), 200 Han EH patients and 216 Han normotensives (controls). Methods All nine tag single-nucleotide polymorphisms (SNPs) within the SELE gene were retrieved from HapMap and the genotyping was performed using a polymerase chain reaction (PCR)/ligase detection reaction assay. Results The distributions of the A-allele frequency of rs3917458 and the C-allele frequency of rs2179172 differed significantly between the hypertensive subjects and controls in the Han population. The frequency of haplotype GGC was significantly higher in the EH group than in the controls in the Mongolian population. In the Han population, a significant difference was observed in the haplotype frequency of TCC between the patients and controls, whereas haplotype ACA was detected significantly less often in the EH subjects than in the controls. Conclusion Meanwhile, the haplotype TCC in the Han hypertensive patients and the haplotype GGC in the Mongolian patients had independent effects in increasing the risk for EH and maybe used as risk factors for predicting high blood pressure. However, the haplotype ACA had an independent effect in decreasing the risk of hypertension and may be protective in normotensive subjects in the Han population. Therefore, multiple SNPs in combination in SELE may confer a risk of hypertension.

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A common missense single nucleotide polymorphism in the E-selectin gene is significantly associated with essential hypertension in the Han population but only weakly associated in the Uygur population

Cited by 16 publications

References 22 publications

E-Selectin Gene Polymorphisms and Essential Hypertension in Asian Population: An Updated Meta-Analysis

E-Selectin Gene Polymorphisms and Essential Hypertension in Asian Population: An Updated Meta-Analysis

CAMK4 gene variation is associated with hypertension in a Uygur population

Associations SELE Gene Haplotype Variant and Hypertension in Mongolian and Han Populations

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