A Common Network of Functional Areas for Attention and Eye Movements

Corbetta, Maurizio; Akbudak, Erbil; Conturo, Thomas E.; Snyder, Abraham Z.; Ollinger, John M.; Drury, Heather A.; Linenweber, Martin R; Petersen, Steven E.; Raichle, Marcus E.; Essen, David C. Van; Shulman, Gordon L.

doi:10.1016/s0896-6273(00)80593-0

Cited by 1,443 publications

(1,064 citation statements)

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“…1998) (IC24) and left‐side‐dominant lateral prefrontal regions peaking at Brodmann's area (BA) 45 (IC18). The secondary analysis detected the posterior default mode network (DMN) (IC28), primary visual cortices (IC13), and executive control network (ECN, IC21) composed of the bilateral anterior dorsolateral and medial prefrontal cortices (MPF) (Duncan and Owen 2000; Smith et al.…”

Section: Resultsmentioning

confidence: 99%

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Dynamic interactions of the cortical networks during thought suppression

et al. 2016

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ObjectivesThought suppression has spurred extensive research in clinical and preclinical fields, particularly with regard to the paradoxical aspects of this behavior. However, the involvement of the brain's inhibitory system in the dynamics underlying the continuous effort to suppress thoughts has yet to be clarified. This study aims to provide a unified perspective for the volitional suppression of internal events incorporating the current understanding of the brain's inhibitory system.Materials and MethodsTwenty healthy volunteers underwent functional magnetic resonance imaging while they performed thought suppression blocks alternating with visual imagery blocks. The whole dataset was decomposed by group‐independent component analysis into 30 components. After discarding noise components, the 20 valid components were subjected to further analysis of their temporal properties including task‐relatedness and between‐component residual correlation.ResultsCombining a long task period and a data‐driven approach, we observed a right‐side‐dominant, lateral frontoparietal network to be strongly suppression related. This network exhibited increased fluctuation during suppression, which is compatible with the well‐known difficulty of suppression maintenance.ConclusionsBetween‐network correlation provided further insight into the coordinated engagement of the executive control and dorsal attention networks, as well as the reciprocal activation of imagery‐related components, thus revealing neural substrates associated with the rivalry between intrusive thoughts and the suppression process.

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Section: Resultsmentioning

confidence: 99%

“…This area has been implicated in a wide variety of functions (Corbetta et al. 1998), including mental imagery (Mellet et al. 1996; Kosslyn and Thompson 2003; Ganis et al.…”

Section: Discussionmentioning

confidence: 99%

Dynamic interactions of the cortical networks during thought suppression

et al. 2016

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“…This is not surprising given that the parietal cortical areas mediating shifts of covert attention and eye movements overlap (Anderson et al, 1994;Corbetta et al, 1998) and that cognitive studies have also shown links between covert and overt attention (Hoffman, 1998;Klein, Kingstone, & Pontefract, 1992). Scinto et al found that individuals with AD were less accurate and slowed in shifting their gaze between a central fixation point and a target dot presented in sequence at peripheral locations.…”

Section: Attention Shiftingmentioning

confidence: 99%

The apolipoprotein E gene, attention, and brain function.

Parasuraman¹,

Greenwood²,

Sunderland³

2002

Neuropsychology

109

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The ɛ4 allele of the apolipoprotein E (ApoE) gene is associated with alterations in brain function and is a risk factor for Alzheimer's disease (AD). Changes in components of visuospatial attention with ApoE-ɛ4, aging, and AD are described. Healthy middle-aged adults without dementia who have the ApoE-ɛ4 gene show deficits in spatial attention and working memory that are qualitatively similar to those seen in clinically diagnosed AD patients. The findings support an association between ApoE polymorphism and specific components of visuospatial attention. Molecular mechanisms that may mediate the ApoE-attention link by modulating cholinergic neurotransmission to the posterior parietal cortex are discussed. Studies of attention and brain function in ApoE-ɛ4 carriers without dementia can advance knowledge of the genetics of visual attention, may enhance understanding of the preclinical phase of AD, and may lead to better methods for early AD detection.Apolipoprotein E (ApoE) is an amino acid glycoprotein that is important in lipid storage, transport, and metabolism (Mahley, 1988). Although synthesized mainly in the liver, ApoE is also found in the peripheral and central nervous systems, including the brain. ApoE has long been of interest in medicine, but its importance in neuroscience increased dramatically with the identification of the ɛ4 allele of the ApoE gene on chromosome 19 as a major risk factor for the development of late-onset Alzheimer's disease (AD) in older adults Strittmatter et al., 1993). This discovery led to a growing number of studies examining the role of the ApoE gene in normal brain function and cognition, as well as in disorders such as AD, brain injury, and stroke (Higgins, Large, Rupniak, & Barnes, 1997;Horsburgh, McCarron, White, & Nicol, 2000; J. D. Smith, 2000).Polymorphisms of the ApoE gene are associated with significant alterations in brain morphology (Plassman et al., 1997) and cognitive functioning, including attention (Greenwood, Sunderland, Friz, & Parasuraman, 2000) and memory (Bondi et al., 1995). Studies of ApoE may thus reveal information relevant to the genetics of attention and memory in normal individuals. At the same time, such studies may identify cognitive and neural changes that may be characteristic of preclinical stages of AD. In this article, we review the role of the ApoE gene in normal cognition and in the development of deficits indicative of early AD.Currently, no reliable methods exist for the early detection and treatment of AD. New techniques for preventing, slowing the progression of, and treating AD are being urgently sought. Such efforts would be aided considerably if AD could be detected prior to the clinical diagnosis of AD and before irreversible brain changes occur (Daffner & Scinto, 2000). Postmortem studies show that neuropathological changes occur decades before the onset of NIH Public Access Author ManuscriptNeuropsychology. Author manuscript; available in PMC 2006 January 25. Published in final edited form as:Neuropsychology. 2002 April ; ...

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“…Several more specific functions have been proposed for this region, including maintenance and manipulation of information in working memory (Goldman-Rakic, 1987;Owen et al, 1996), attentional control (Corbetta et al, 1998), choosing between alternative responses (Rowe et al, 2000), and representation and storage of the rules of a task (Miller et al, 2002;Derrfuss et al, 2004). The neuronal circuitry required to implement these functions is not yet well understood.…”

Section: Introductionmentioning

confidence: 99%