A compact gamma camera for biological imaging

Bradley, Eric L.; Cella, J.; Majewski, S.; Popov, V.; Qian, Jing; Saha, Margaret S.; Smith, Mark F.; Weisenberger, A.G.; Welsh, Robert E.

doi:10.1109/tns.2005.862977

Cited by 25 publications

(18 citation statements)

References 23 publications

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“…Yet the combined sensitivity of these one hundred pinholes would be equivalent to a single 1.0 mm diameter pinhole. It is possible that micro-channel parallel hole [44], [45] or multiple slit [46] collimators might better use the high intrinsic resolution of an EMCCD based gamma camera to find a good balance between sensitivity and resolution in preclinical SPECT imaging.…”

Section: Discussionmentioning

confidence: 99%

“…The simplest form of imaging is non-volumetric, but has several shortcomings 45 : its ineffectiveness in precisely localizing cell populations hampers its use as a visualization tool, while uncertainty in estimation of tumor burden at deep sites impairs its use as a quantitative tool.. To obviate these shortcomings while retaining the temporal advantages of planar imaging, we have built a compact multi-camera system to efficiently perform volumetric imaging. We have chosen back-illuminated CCDs (originally Scientific Imaging Technologies Inc., Tigard, OR, now replaced with equivalent CCDs by e2v technologies inc., Elmsford, NY) because of their high quantum efficiency over a broad range of wavelengths (50-95% between 390 and 930 nm).…”

Section: Body Light Emission Tomographymentioning

confidence: 99%

See 1 more Smart Citation

Investigation of Metastatic Breast Tumor Heterogeneity and Progression Using Dual Optical/SPECT Imaging

Antich¹,

Constantinescu²,

Lewis³

et al. 2007

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATE 01-05-20072. REPORT TYPE Final DATES COVERED PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBERThe University of Texas Southwestern Medical Center at Dallas Dallas, TX 75390-9105 SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited SUPPLEMENTARY NOTESOriginal contains colored plates: ALL DTIC reproductions will be in black and white. ABSTRACTThe goal of our project is to image the processes that occur during tumor growth and metastatic spread or regression including the fate of minimal residual disease. To do so it is necessary to test the limits of sensitivity of newly developed techniques: our technical goal is to develop integrated light emission and single photon emission tomography. We have made substantial progress in our techniques for the detection of metastases. We have demonstrated our capability to detect millimeter or sub-millimeter metastases in mice by light emission. To this end we have used Light Emission Tomography (LET), a technique based on bioluminescence of cancer cells infected with luciferase, to detect metastases in the lung and head. We have begun assessment of perfusion using fluorescence imaging. In addition, our technological focus is on the simultaneous use of Single-photon Emission Computed Tomography (SPECT), and to this end we have developed a new form of micro-SPECT based on cooled, electron-multiplied Charge-Coupled Devices (EMCCDs) with which we are performing ongoing imaging experiments. We have also collaborated on the assessment of a new, promising SPECT imaging agent, clioquinol or Iodinated hydroxyquinoline. We will use bioluminescence imaging to test if clioquinol imaging detects areas where tumor cells proliferate and establish metastases and to identify the relative times at which the images first appear. SUBJECT TERMS INTRODUCTIONBecause growth of very small tumors has not been s...

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Section: Discussionmentioning

confidence: 99%

Section: Body Light Emission Tomographymentioning

confidence: 99%

Investigation of Metastatic Breast Tumor Heterogeneity and Progression Using Dual Optical/SPECT Imaging

Antich¹,

Constantinescu²,

Lewis³

et al. 2007

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“…。 Gregory Jerome Gruber [18] used compact gamma cameras for breast cancer or breast detection. Eric L.Brandly [19] et.al designed the mouse imaging with resolution and sensitivity based on the size of the mouse. Soluria et.al [20] developed a SSR method for molecular imaging and small animal imaging based on high resolution Gamma Camera, which significantly improved the spatial resolution.…”

Section: Applicationmentioning

confidence: 99%

Development and Application of Gamma Camera in the Field of Nuclear Medicine

Yang¹,

Yang²,

Yang³

2018

ijSciences

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Abstract:The gamma camera provides fast and accurate real-time imaging of the distribution of radionuclides in the human body. It can not only perform dynamic and static observations, but also can be used to observe the metabolism of local tissue organs. It is an important tool in the field of nuclear medicine. This paper introduces the principle, structure and performance index of gamma camera, and summarizes and analyzes the application and development status of gamma camera in nuclear medicine. The performance indicators of gamma cameras have been greatly improved, and have been widely used in the medical field.

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“…In preclinical SPECT imaging system development, the primary emphasis has been almost exclusively in improving spatial resolution (Jaszczak et al 1994, Ishizu et al 1995, Weber et al 1999, Wu et al 2000, Meikle et al 2001, Acton and Kung 2003, Furenlid et al 2004, Beekman et al 2005, Madsen 2007)—a sensible and predictable approach given the small size of the imaging subjects' organs. In preclinical SPECT systems and research, pinholes or other collimators are used to form an image of the subject (Meikle et al 2005, Loudos et al 2003, Bradley et al 2006, Beekman and van der Have 2007, Franc et al 2008). Many systems have achieved impressive spatial resolution, but this comes with the expense of limited sensitivity (Madsen 2007).…”

Section: Introductionmentioning

confidence: 99%

A high-sensitivity small animal SPECT system

Mitchell¹,

Cherry²

2009

Phys. Med. Biol.

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Medical imaging using single gamma ray emitting radionuclides typically makes use of parallel hole collimators or pinholes in order to achieve good spatial resolution. However, a tradeoff in sensitivity is inherent in the use of a collimator, and modern preclinical SPECT (single photon emission computed tomography) systems detect a very small fraction of emitted gamma rays, often less than 0.1%. A system for small animal SPECT imaging which uses no collimators could potentially achieve very high sensitivity-several tens of percent-with reasonably sized detectors. This would allow two significant improvements in preclinical studies: images could be obtained more rapidly, allowing higher throughput for screening applications, or for dynamic processes to be observed with very good time resolution; and images could be obtained with less radioactive tracer, making possible the in vivo imaging of low-capacity receptor systems, aiding research into new tracer compounds, and reducing the cost and easing the regulatory burden of an experiment. Of course, a system with no collimator will not be able to approach the sub-millimeter spatial resolutions produced by the most advanced pinhole and collimated systems, but a high sensitivity system with resolution of order one centimeter could nonetheless find significant and new use in the many molecular imaging applications which do not require good spatial resolution-for example, screening applications for drug development or new imaging agents. Rather than as an alternative to high resolution SPECT systems, the high sensitivity system is proposed as a radiotracer alternative to optical imaging for small animals. We have developed a prototype system for mouse imaging applications. The scanner consists of two large, thin, closely spaced scintillation detectors. Simulation studies indicate that a FWHM spatial resolution of 7 mm is possible. In an in vivo mouse imaging study using the 99m Tc labeled tracer MAG-3, the sensitivity of the system is measured to be 40%. Simple projection images created by analytically combining the two detectors' data show sufficient resolution to observe the dynamic distribution of the radiotracer in the mouse.

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A compact gamma camera for biological imaging

Cited by 25 publications

References 23 publications

Investigation of Metastatic Breast Tumor Heterogeneity and Progression Using Dual Optical/SPECT Imaging

Investigation of Metastatic Breast Tumor Heterogeneity and Progression Using Dual Optical/SPECT Imaging

Development and Application of Gamma Camera in the Field of Nuclear Medicine

A high-sensitivity small animal SPECT system

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