A compactibility-based lubricant dispersion model describing the effect of formulation and paddle speed

Puckhaber, Daniel; Schomberg, Ann Kathrin; Kwade, Arno; Finke, Jan Henrik

doi:10.1016/j.ijpharm.2022.122300

International Journal of Pharmaceutics

2022

DOI: 10.1016/j.ijpharm.2022.122300

|View full text |Cite

A compactibility-based lubricant dispersion model describing the effect of formulation and paddle speed

Daniel Puckhaber

Ann Kathrin Schomberg

Arno Kwade

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

2024

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 5 publications

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Investigation of Dispersion Kinetics of Particulate Lubricants and their Effect on the Mechanical Strength of MCC Tablets

Puckhaber,

Kwade,

Finke

2023

Pharm Res

View full text Add to dashboard Cite

Introduction Tablets are commonly produced by internally adding particulate lubricants, which are known to possibly lower the mechanical strength of tablets. This reduction is caused by the coverage of matrix forming components by lubricant particles, resulting in decreased interparticulate interactions. The known incompatibilities with some active compounds of the predominantly used lubricant, magnesium stearate, call for the in-depth characterization of alternative lubricants. Purpose Investigation of the dispersion behavior of five commonly applied pharmaceutical lubricants by mathematically modeling the dispersion kinetics for short and extended mixing times. Methods The dispersion behavior of five different pharmaceutical lubricants were examined by systematically varying lubricant concentration and mixing time of binary formulations and evaluating the kinetic of tensile strength reduction by theoretically estimating the surface coverage based on particle sizes. Results For short mixing times, a unifying relationship between compactibility reduction and theoretical surface coverage was identified. Subsequently, for extended mixing times, distinct differences in the shear strength and dispersion kinetics of the investigated lubricants were found. Conclusions The lubricant particle size controls the tensile strength reduction if short mixing times are applied. For extended mixing times, the investigated lubricants can be divided into two groups in terms of dispersion kinetics. Possible underlying reasons are discussed in detail in order to enhance the general understanding of lubricant dispersions in tablet formulations.

show abstract

Investigation of Dispersion Kinetics of Particulate Lubricants and their Effect on the Mechanical Strength of MCC Tablets

Puckhaber,

Kwade,

Finke

2023

Pharm Res

View full text Add to dashboard Cite

show abstract

Enhanced multi-component model to consider the lubricant effect on compressibility and compactibility

Puckhaber

Voges

Rane

et al. 2023

European Journal of Pharmaceutics and Biopharmaceutics

View full text Add to dashboard Cite

A systematic investigation of external lubrication of mini-tablets on a rotary tablet press with focus on the tensile strength

Lura,

Klinken,

Breitkreutz

2024

European Journal of Pharmaceutics and Biopharmaceutics

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

A compactibility-based lubricant dispersion model describing the effect of formulation and paddle speed

Cited by 5 publications

References 35 publications

Investigation of Dispersion Kinetics of Particulate Lubricants and their Effect on the Mechanical Strength of MCC Tablets

Investigation of Dispersion Kinetics of Particulate Lubricants and their Effect on the Mechanical Strength of MCC Tablets

Enhanced multi-component model to consider the lubricant effect on compressibility and compactibility

A systematic investigation of external lubrication of mini-tablets on a rotary tablet press with focus on the tensile strength

Contact Info

Product

Resources

About