2024
DOI: 10.1101/2024.06.27.600954
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A comparative analysis across species of maternal mRNA regulation in embryos using QUANTA

Mazal Tawil,
Dina Alcalay,
Pnina Greenberg
et al.

Abstract: The post-transcriptional regulation of mRNAs greatly impacts gene expression dynamics, but the underlying regulatory kinetics and sequence rules and how they change between organisms remain elusive. Thousands of pre-loaded maternal transcripts are post-transcriptionally regulated within metazoan embryos, making it an ideal system to investigate mRNA regulation. We present QUANTA, a computational strategy to distinguish transcriptionally silent genes and analyze their regulation. QUANTA uses kinetic models to c… Show more

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