A comparative clinical study of intrathecal bupivacaine 2.5 mg with dexmedetomidine 5 μg versus intrathecal bupivacaine 2.5 mg with fentanyl 25 μg on the duration of labor analgesia using combined spinal epidural technique

Jain, Neena; Mathur, Pooja; Soni, Poorva; Veena, P.; Sethi, Surendra Kumar; Mathur, Veena

doi:10.4103/joacc.joacc_21_18

Cited by 6 publications

(12 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There was no significant difference between the B-D and B-F groups in terms of SBP, DBP, HR, MAP, and SpO2 at most of the studied times, which is in accordance with the results of the previous studies. 3,16,18,21 Moreover, the findings of this study revealed the usage of ephedrine and atropine had no significant difference between the two groups, which were similar to the other studies. 3,22,23 However, Contractor et al showed that the probability of MAP and HR decrease was higher in the Dex group compared to the control group.…”

Section: Discussionsupporting

confidence: 88%

“…3,16,18,21 Moreover, the findings of this study revealed the usage of ephedrine and atropine had no significant difference between the two groups, which were similar to the other studies. 3,22,23 However, Contractor et al showed that the probability of MAP and HR decrease was higher in the Dex group compared to the control group. 8 It is worth mentioning that in the mentioned study, the patients received intravenous Dex infusion under spinal anesthesia.…”

Section: Discussionsupporting

confidence: 88%

“…2 Moreover, compared with the B-F group, the duration of analgesia in the B-D group was significantly longer. The mentioned findings were entirely consistent with the results of studies by Jain et al and Gupta et al 3,18 In another fascinating study, Shukla et al compared the effect of adding Dex and MgSO 4 to intrathecal bupivacaine and found that the onset of block was faster in the Dex group and duration of analgesia also was significantly longer in Dex group. 21 The results of the present study were in contrast with those of the Khalifa et al study; however, it is worth noting that the mentioned study used sufentanyl 0.1 μg instead of fentanyl and did not find any significant difference between the sufentanyl and Dex groups regarding the duration of postoperative analgesia.…”

Section: Discussionsupporting

confidence: 87%

“…Nowadays, many drugs including opioids, magnesium sulfate, vasopressors, and α 2 -adrenergic agonists (dexmedetomidine and clonidine) have been tried extensively as an adjuvant to local anesthetic and provide some advantages not only to manage postoperative pain but also to optimize satisfaction of patients. [2][3][4] Fentanyl is the most common short-acting opioid that is used intrathecally in combination with local anesthetics. It has synergistic effects with local anesthetics and improves the status of intraoperative and postoperative analgesia.…”

Section: Introductionmentioning

confidence: 99%

“…It has synergistic effects with local anesthetics and improves the status of intraoperative and postoperative analgesia. 3 It has been reported that intrathecal administration of fentanyl at the dose of 10-25 microgram can prolong the duration of postoperative analgesia for approximately 180-240 min. 5 However, intrathecal opioids can cause some side effects such as itching, urinary retention, nausea and vomiting as well as respiratory depression.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

<p>Comparative Study of Fentanyl vs Dexmedetomidine as Adjuvants to Intrathecal Bupivacaine in Cesarean Section: A Randomized, Double-Blind Clinical Trial</p>

Khosravi¹,

Sharifi²,

Jarineshin³

2020

JPR

View full text Add to dashboard Cite

Purpose: Effective postoperative analgesia is essential in cesarean section. This study aimed to compare postoperative analgesia and hemodynamic changes after intrathecal use of fentanyl or dexmedetomidine combined with bupivacaine. Patients and Methods: This study involved 110 pregnant women with ASA I and II and gestational age ≥37 weeks who were candidates for elective cesarean section. They were randomly divided into two groups of 55; Group B-D received 10 mg bupivacaine (0.5%) + 5 μg dexmedetomidine and Group B-F received 10 mg bupivacaine (0.5%) + 25 μg fentanyl, intrathecally. The onset of block, duration of analgesia, the score of pain intensity, hemodynamic changes, Apgar scores, and any adverse events were evaluated. P-value <0.05 was considered statistically significant. Results: Patients in two groups were similar in terms of demographic characteristics and ASA classification. Duration of analgesia in the B-D group was significantly longer than B-F group (428.64±73.39 vs 273.18±61.91 min; P<0.001). The score of pain intensity during recovery time in the B-D group was significantly lower than that of B-F group (0.33±0.84 vs 0.51±0.57 min; P=0.004). The onset of block was also faster in the B-D group than B-F group (98.27±35.95 vs 110.45±37.69 seconds; P=0.036). The two groups did not show significant differences in hemodynamic changes and other variables (P>0.05). Conclusion: Compared with fentanyl, it seems that adding 5 μg dexmedetomidine to bupivacaine has a better effect on postoperative pain management in cesarean section under spinal anesthesia.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

<p>Comparative Study of Fentanyl vs Dexmedetomidine as Adjuvants to Intrathecal Bupivacaine in Cesarean Section: A Randomized, Double-Blind Clinical Trial</p>

Khosravi¹,

Sharifi²,

Jarineshin³

2020

JPR

View full text Add to dashboard Cite

show abstract

Fentanyl versus midazolam added to bupivacaine for spinal analgesia in children undergoing infraumbilical abdominal surgery: A randomized clinical trial

AbdelRady

Abdelrahman

Ali

et al. 2022

Egyptian Journal of Anaesthesia

View full text Add to dashboard Cite

Analgesic Effects, Birth Process, and Prognosis of Pregnant Women in Normal Labor by Epidural Analgesia Using Sufentanil in Combination with Ropivacaine: A Retrospective Cohort Study

Mao

Zhang

Zhu

2022

Computational Intelligence and Neuroscience

View full text Add to dashboard Cite

Objective. The objective is to evaluate the analgesic, labor, and prognostic effects of patient-controlled epidural analgesia (PCEA) versus sufentanil in conjunction with ropivacaine in normal labor. Methods. Sixty pregnant women who had a normal delivery at our hospital between February 2019 and April 2021 were included. Pregnant women were arbitrarily assigned to a control group and a research group. Pregnant women in the control group received lidocaine analgesia and PCEA with sufentanil combined with ropivacaine in the research group. Satisfaction with care, fetal umbilical artery blood flow, VAS score, labor and bleeding, neonatal Apgar score and incidence of adverse events were analyzed. Results. First, we made a comparison of satisfactory performance of nursing care. The satisfaction rate of the research group was 100.00%, compared to 83.33% for the control group. Nursing satisfaction was higher in the research group, and the difference was statistically significant ( P < 0.05 ). Following analgesia, PI, RI, and S/D values of umbilical artery blood flow were lower in the research group than those in the control group, but the difference was not statistically significant ( P > 0.05 ). The VAS scores at 10 min, 20 min, and 30 min were found to be lower in the research group than in the control group after analgesia, and the difference was statistically significant ( P < 0.05 ). Bleeding was significantly lower in the research group for all stages of labor, and the difference was statistically significant ( P < 0.05 ). Apgar scores at 1 minute, 5 minutes, and 10 minutes postpartum were greater in the research group than in the control group, and the difference was statistically significant ( P < 0.05 ). As a final note, the incidence of pruritus, hypotension, respiratory depression, nausea, and vomiting was found to be lower in the research group than in the control group, and the difference was statistically significant ( P < 0.05 ). Conclusion. PCEA with sufentanil coupled with ropivacaine was used to perform labor analgesia. With significant reduction in maternal pain and assurance of labor, ropivacaine combined with sufentanil epidural labor analgesia did not reduce fetal umbilical artery blood flow without extended labor. It could not affect the labor process or the safety of the fetus, which is safe for the mother and fetus.

show abstract

A comparative clinical study of intrathecal bupivacaine 2.5 mg with dexmedetomidine 5 μg versus intrathecal bupivacaine 2.5 mg with fentanyl 25 μg on the duration of labor analgesia using combined spinal epidural technique

Cited by 6 publications

References 2 publications

<p>Comparative Study of Fentanyl vs Dexmedetomidine as Adjuvants to Intrathecal Bupivacaine in Cesarean Section: A Randomized, Double-Blind Clinical Trial</p>

<p>Comparative Study of Fentanyl vs Dexmedetomidine as Adjuvants to Intrathecal Bupivacaine in Cesarean Section: A Randomized, Double-Blind Clinical Trial</p>

Fentanyl versus midazolam added to bupivacaine for spinal analgesia in children undergoing infraumbilical abdominal surgery: A randomized clinical trial

Analgesic Effects, Birth Process, and Prognosis of Pregnant Women in Normal Labor by Epidural Analgesia Using Sufentanil in Combination with Ropivacaine: A Retrospective Cohort Study

Contact Info

Product

Resources

About