A comparative evaluation of bone regeneration using mesenchymal stem cells versus blood coagulum in sinus augmentation procedures

Abstract

Objective: The present study evaluated the quality and quantity of new bone formation in the maxillary sinus lift procedures and stability of implants in posterior atrophic maxilla. Materials and Methods: This prospective randomized controlled split-mouth study included 20 patients (16 males and 4 females having a mean age of 36.7 years) having atrophic maxilla. They were divided randomly into two groups: Group A using mesenchymal stem cells and Group B into blood coagulum. They were radiographically evaluated using cone-beam computed tomography (CBCT) for residual bone height preoperatively and availability of new bone formation around implants, density, and stability of implants 6 months postoperatively. Results: The placement of dental implants in posterior maxilla is challenging due to rapid resorption of alveolar bone after extraction of teeth due to pneumatization of maxillary sinuses. In both the groups, more pain and swelling were observed in the 2nd postoperative day which gradually decreased over a period of 7 days. Membrane perforation occurs in only four cases (20%). A significant gain in alveolar bone height was observed in Group A (7.69 mm ± 2.5 mm) and Group B (9.32 mm ± 2 mm) after 6 months. On comparing both the groups, there is a similar significant increase in bone density in Hounsfield units postoperatively at various levels buccally and palatally. Total 40 sinuses were lifted and 42 implants were placed, respectively. All implants showed primary stability. Conclusions: Such findings provide a significant contribution in future perspective studies that the use of stem cells had the same success rate as blood coagulum.

Comparative efficacy of osteotome versus CAS kit-assisted indirect maxillary sinus lift and immediate implant placement in posterior atrophic maxilla: A clinico-radiological study

“…Another study performed by Gupta et al, 17 in which bone regeneration was evaluated using mesenchymal stem cell and blood coagulum, found bone regeneration to be 7.69+2.5 mm and 9.32+2 mm respectively for stem cell and blood coagulum after six months of the follow-up period. Nedir et al 18 in 2013 showed that the bone gain was higher in the graft group (4.6AE1.4 mm) than in the non-graft group (3.3AE1.5 mm).…”