A Comparative Evaluation of the Efficacy of Garlic and Propolis Extracts Against Candidaalbicans With Amphotericin-B as Control - An in-Vitro Study.

Abstract

Introduction: -Oral candidiasis is an infection of oral cavity caused by an over growth of candida species. The proportions of yeast in the periodontal pockets are similar to some of periodontal bacteria, thus suggesting the possible role of Candida species in pathogenesis of periodontal pocket. The plant extract such as garlic and propolis, contain bioactive components which act against these organisms with no or less side effects than by the conventional antibiotics. Objectives: - To evaluate the efficacy of garlic and propolis extracts against candida albicans and compare it with Amphotericin-B as control at 3 different concentrations Methodology: - Subgingival plaque samples were collected and selectively cultivated for candida albicans. The antimicrobial activity of propolis and garlic was assessed and compared with Amphotericin-B. Conclusion: Garlic extract can be used as a potent agent in the eradication of candida albicans in chronic periodontitis patient.

Garlic (Allium sativum L.) Bioactives and Its Role in Alleviating Oral Pathologies

“…In another in vitro experiment, the efficacy of three different concentrations (10, 20, and 30%) of garlic and propolis extract against C. albicans is examined and compared it with amphotericin-B 10 mg (control) at 24 and 48 h. They did not find a significant difference in inhibition of candidal growth at 10% concentration. However, at 20 and 30% concentrations, complete inhibition of the growth of C. albicans with GE was evident at both 24 and 48 h. Propolis could not inhibit the candidal growth with 10 and 20% concentration at 24 and 48 h, but it showed inhibition at 30% concentration at 24 h duration [ 70 ]. Thus, it was concluded that GE could be a potential agent in eradicating C. albicans in chronic periodontitis patients.…”