A comparative genetic approach for the investigation of ageing grey horse melanoma

Rieder, Stefan; Stricker, Christian; Joerg, H.; Dummer, Reinhard; Stranzinger, G.

doi:10.1111/j.1439-0388.2000x.00245.x

Cited by 45 publications

(36 citation statements)

References 25 publications

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“…In greying level (L*) an odds of melanoma occurrence was estimated to be 1.11 times higher. The estimated higher odds of melanoma occurrence for a higher greying level contradicts the assumption that the loss of pigment need not be a cause of the appearance of dermal melanoma (Rieder et al, 2000;Hofmanová et al, 2010). Table 4 shows the estimations of variance components based on LM, TM, and TMb models.…”

Section: Analysis Of Environmental Effectscontrasting

confidence: 41%

“…On the other hand, Rieder et al (2000) and Hofmanová et al (2010) found the influence of L value on melanoma occurrence to be statistically not significant at the evaluation on the same significance level (P < 0.05).…”

Section: Analysis Of Environmental Effectsmentioning

confidence: 96%

“…Data in literature suggest an association between the process of greying and melanoma occurrence (Sölkner et al, 2004). However, Rieder et al (2000) stated that greying cannot be considered as a direct cause of melanoma appearance.…”

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confidence: 99%

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Estimation of genetic parameters for melanoma in the Old Kladruber horse

Vostrý¹,

Hofmanová²,

Vydrová³

et al. 2012

CZECH J ANIM SCI

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ABSTRACT:The aim of this study was to assess the prevalence of melanoma to investigate a possible genetic variation of this trait in the Old Kladruber horse. A total of 564 grey varieties of the Old Kladruber horse, 238 males and 326 females, with five generations of ancestors (n = 1245 animals) were analysed. Melanoma status was recorded for different stages. Three different analyses were conducted: a linear animal model (LM) with melanoma classified into five categories, threshold animal model (TM) with melanoma classified into five categories and threshold animal model (TMb) with melanoma classified into two categories (0 = absence, 1 = presence). All models included the fixed effects of year of evaluation, age, line, sex, greying level, random direct genetic effect, and the effect of animal's permanent environment. Heritability for melanoma occurrence was estimated for LM -0.09, for TM -0.27, and for TMb -0.11. The coefficient of repeatability was estimated for LM -0.77, for TM -0.90, and for TMb -0.99. The values of the Pearson's correlation coefficient and Spearmen's rank correlation coefficient among breeding values estimated by LM, TM, and TMb models were from 0.82 to 0.88 and from 0.83 to 0.90, respectively, for data with pedigree information and from 0.77 to 0.84 and 0.77 to 0.88, respectively, for a subset of animals with measurements. Results suggest that additive genetic variation of melanoma occurrence in the Old Kladruber horse seems large enough to be exploited in a specific breeding programme.

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Section: Analysis Of Environmental Effectscontrasting

confidence: 41%

Section: Analysis Of Environmental Effectsmentioning

confidence: 96%

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Estimation of genetic parameters for melanoma in the Old Kladruber horse

Vostrý¹,

Hofmanová²,

Vydrová³

et al. 2012

CZECH J ANIM SCI

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“…Additionally, other traits of significance such as coat color, etc., can be better addressed by understanding the molecular cause of variation in expression. Recent studies have shown that the mouse cannot be 'taken for granted' as a model animal for all human conditions (Rieder et al 2000;Heinzerling et al 2001), and that in some cases, the horse can be a better model (Rieder et al 2000).…”

Section: Tammen]mentioning

confidence: 99%

The First-Generation Whole-Genome Radiation Hybrid Map in the Horse Identifies Conserved Segments in Human and Mouse Genomes

Chowdhary¹,

Raudsepp²,

Kata³

et al. 2003

Genome Res.

137

130

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A first-generation radiation hybrid (RH) map of the equine (Equus caballus) genome was assembled using 92 horse × hamster hybrid cell lines and 730 equine markers. The map is the first comprehensive framework map of the horse that (1) incorporates type I as well as type II markers, (2) integrates synteny, cytogenetic, and meiotic maps into a consensus map, and (3) provides the most detailed genome-wide information to date on the organization and comparative status of the equine genome. The 730 loci (258 type I and 472 type II) included in the final map are clustered in 101 RH groups distributed over all equine autosomes and the X chromosome. The overall marker retention frequency in the panel is ∼21%, and the possibility of adding any new marker to the map is ∼90%. On average, the mapped markers are distributed every 19 cR (4 Mb) of the equine genome-a significant improvement in resolution over previous maps. With 69 new FISH assignments, a total of 253 cytogenetically mapped loci physically anchor the RH map to various chromosomal segments. Synteny assignments of 39 gene loci complemented the RH mapping of 27 genes. The results added 12 new loci to the horse gene map. Lastly, comparison of the assembly of 447 equine genes (256 linearly ordered RH-mapped and additional 191 FISH-mapped) with the location of draft sequences of their human and mouse orthologs provides the most extensive horse-human and horse-mouse comparative map to date. We expect that the foundation established through this map will significantly facilitate rapid targeted expansion of the horse gene map and consequently, mapping and positional cloning of genes governing traits significant to the equine industry.

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“…It is, nowadays, accepted as a true neoplasm (Gorham and Robl 1986, Macgillivray et al 2002, PattersonKane and Ginn 2003, Seltenhammer et al 2004. Several research groups have investigated the genetic basis of melanoma formation and found a link between the autosomal dominant trait of greying with age and melanoma formation in horses (Rieder et al 2000, Seltenhammer et al 2003, Rosengren Pielberg et al 2008, Sundstrom et al 2012). …”

Section: Introductionmentioning

confidence: 99%

Prospect for immunological therapies of the equine malignant melanoma

Cavalleri¹,

Mählmann²,

Schuberth³

et al. 2015

PHK

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Summary: Although equine melanocytic neoplasms occur frequently, at least in grey horses, their existence is neglected frequently, despite their potentially severe clinical consequences. Immune-based therapies have been investigated in human metastatic melanoma and offer encouraging results. Researchers have recently begun to explore the immunological approach in equine malignant melanoma (EMM) with some success. Therefore, this review aims at giving a short overview of the nature of EMM and providing insight into the immunological basis of melanocytic neoplasms in general. Equine malignant melanoma is a true neoplasm with a genetic basis. Initially they show a slow invasive growth, but they have the potential to metastasize. EMM and human malignant melanomas share various common histopathologic features. For the immune system eradication of the tumor is a challenge. Although solid tumors are often infiltrated with immune cells, they usually do not induce a significant tumor remission. The antitumoral immune response depends on factors of the innate immune system interacting in a coordinated fashion with the adaptive immune system. Antigen-presenting cells, neutrophilic granulocytes, and lymphoid cells may elicit antitumoral effects. This innate response precedes a downstream antigen-specific response. In the tumor microenvironment of solid tumors immune suppressive factors can induce immune escape mechanisms of the tumors. Immunological therapies of EMM include blockage of histamine 2 receptors on melanoma cells and lymphocytes, cancer vaccines and gene therapeutic approaches. This article focuses on the immunological therapeutic approach of EMM and gives an outlook on future implications.

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A comparative genetic approach for the investigation of ageing grey horse melanoma

Cited by 45 publications

References 25 publications

Estimation of genetic parameters for melanoma in the Old Kladruber horse

Estimation of genetic parameters for melanoma in the Old Kladruber horse

The First-Generation Whole-Genome Radiation Hybrid Map in the Horse Identifies Conserved Segments in Human and Mouse Genomes

Prospect for immunological therapies of the equine malignant melanoma

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