“…The economic parameters that can potentially be included in the sustainability calculation of the metabolic flux set are, for example, media compound costs, market price of product components, and waste management costs (or negative price of the produced components) [30] , [31] . Environmental impacts can be assessed according to the well-established LCA methodology [32] and media compounds and product components can be characterized by their aquatic acidification potential, aquatic eutrophication potential, aquatic ecotoxicity potential, terrestrial eco-toxicity potential, terrestrial acidification/nutrification potential, abiotic depletion potential, and global warming potential [33] , [34] calculated based on the data available in such databases as Ecoinvent or GaBi and others [35] . The LCA impact categories or other relevant approaches [36] can be used to also assess the societal sustainability via e.g., the human health impacts of the media compounds and product components by their human toxicity potential, ozone depletion potential, photochemical oxidant creation potential, as well as impacts of urban, agricultural, natural land occupation potential, public opinion and social acceptance, and jobs created.…”