A Comparative Phytochemical and Biological Study between Different Solvent Extracts of &amp;lt;i&amp;gt;Bombax ceiba &amp;lt;/i&amp;gt;Roots Available in Bangladesh

Hoque, Nazmul; Rahman, Sabera; Jahan, Ishrat; Shanta, Meena Afroze; Tithi, Nigar Sultana; Nasrin, Nishat

doi:10.4236/pp.2018.92006

Cited by 2 publications

(4 citation statements)

References 24 publications

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“…The freeradical scavenging activity of C. aurantifolia peel fractions was measured by the ability to decrease the absorbance of methanol solution of DPPH (2,2diphenyl-1-picrylhydrazyl). 15,19 Solution of DPPH having concentration of 400 µg/ml was prepared of which 100 µL was transferred to solutions of petroleum ether (PECA), chloroform (CFCA) and hydromethanol (HMCA) fractions having different concentrations from 400 to 12.5 µg/ml. Ascorbic acid was used as the standard which have undergone the same treatment.…”

Section: Preliminary Phytochemical Screeningsmentioning

confidence: 99%

“…Total flavonoids were measured using aluminum trichloride reagent. 15,21 For standard, quercetin of different concentrations ranging from 50 to 250 µg/ml was used with and solution of PECA, CFCA and HMCA were prepared with a concentration of 200 µg/ml. Solution of 5% NaNO 2, followed by 10% AlCl 3, 2% NaOH and finally distilled water were added to the solution of fractions and standard.…”

Section: Preliminary Phytochemical Screeningsmentioning

confidence: 99%

“…8,[10][11][12][13] Literature review demonstrated very little work on methanol extracts of C. aurantifolia peel. As part of our ongoing research on Bangladeshi medicinal plants 4, [14][15][16] and to establish the scientific basis of above stated traditional uses of this plant, the current study was designed to evaluate the antioxidant, antibacterial and cytotoxic potential of the various fractions of methanol extract of C. aurantifolia peel by various in vitro approaches.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant, Antimicrobial and Cytotoxic Activities of Different Fractions of Citrus aurantifolia Peel

Ghosh

Hoque

Shanta

et al. 2020

Dhaka Univ. J. Pharm. Sci

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The present study was designed to investigate antioxidant, antimicrobial and cytotoxic effects of petroleum ether, chloroform and hydromethanol fraction of methanol extract of Citrus aurantifolia peel. Preliminary phytochemical screening of the fractions was done following the standard procedure. Antioxidant activity was measured using DPPH free radical scavenging assay besides measuring total phenolic and flavonoid content using Folin-Ciocalteu reagent and aluminum trichloride method, respectively. The antimicrobial activity was conducted by disc diffusion method and cytotoxic activity was determined by brine shrimp lethality bioassay. The results of phytochemical screening were indicative of the presence of steroids, alkaloids, saponins, glycosides, flavonoids in the fractions. A dose dependent scavenging activity was observed in DPPH radical scavenging assay where chloroform fraction demonstrated the highest activity with IC50 value of 153.68 ± 3.60 μg/ml. The highest phenolic content was observed in chloroform fraction (308.0 ± 6.55 mg/g gallic acid equivalent) and highest flavonoid content was found in hydromethanol fraction (132.66 ± 2.36 mg/g quercetin equivalent). The chloroform fraction showed excellent antibacterial activity against all the tested bacteria where highest zone of inhibition (19 mm) was produced against Bacillus cereus. In brine shrimp lethality bioassay, LC50 values for petroleum ether, chloroform and hydromethanol fractions were 367.39 μg/ml, 228.14 μg/ml and 296.52 μg/ml, respectively. The present findings suggested that C. aurantifolia peel could be a potent source of medicinally important secondary metabolites and further investigations can be done to identify those active compounds responsible for such bioactivity. Dhaka Univ. J. Pharm. Sci. 19(2): 161-168, 2020 (December)

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Section: Preliminary Phytochemical Screeningsmentioning

confidence: 99%

Section: Preliminary Phytochemical Screeningsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antioxidant, Antimicrobial and Cytotoxic Activities of Different Fractions of Citrus aurantifolia Peel

Ghosh

Hoque

Shanta

et al. 2020

Dhaka Univ. J. Pharm. Sci

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“…13 Later, five pure compounds, of which, two were sterols and three were phenols, were isolated from this plant which showed potential cytotoxicity against Vero cell lines. 14 As a part of our ongoing research on Bangladeshi medicinal plants [13][14][15][16][17][18] , evaluation of the CNS depressant and analgesic activities of T. maxima were attempted.…”

Section: Introductionmentioning

confidence: 99%

CNS Depressant and Analgesic Activities of Thysanolaena maxima Roxb. Available in Bangladesh

Hoque

Fatemee

Hossain

et al. 2021

Dhaka Univ. J. Pharm. Sci

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In Bangladesh, numerous tribal people of Chittagong Hill Tracts have been using different parts of Thysanolaena maxima Roxb. for many years. The present study was designed to investigate CNS depressant and analgesic activities of methanol extract of the aerial parts of the plant in mice models. CNS depressant activity of the crude extract (200 and 400 mg/kg) was evaluated using open field, hole cross and thiopental-induced sleeping time tests using diazepam as the standard. Analgesic activity was determined using acetic acid-induced writhing and hot plate tests using diclofenac sodium as the standard. The extract showed dose dependent suppression of locomotion in open field and hole cross tests and exerted sedative action in thiopental induced sleeping time. In the open field and the hole-cross tests, maximum CNS depressant activity was observed at 90 min after administration of extract and the standard drug. The extract significantly induced the onset of sleep and prolonged the sleeping time in thiopental induced sleeping test compared to the control group. The extract produced significant (p < 0.05) analgesic activity by inhibiting writhing by 41.89% and 60.81%, at doses of 200 and 400 mg/kg body weight, respectively, which was comparable to the inhibition of diclofenac sodium (73.64%). Additionally, in hot plate test, the extract exhibited a significant (p < 0.05) increase in pain threshold in a dose dependent manner. The findings of the study are encouraging and demands further investigation of other bioactivities with isolation of pure compounds. Dhaka Univ. J. Pharm. Sci. 20(2): 227-233, 2021 (December)

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A Comparative Phytochemical and Biological Study between Different Solvent Extracts of <i>Bombax ceiba </i>Roots Available in Bangladesh

Cited by 2 publications

References 24 publications

Antioxidant, Antimicrobial and Cytotoxic Activities of Different Fractions of Citrus aurantifolia Peel

Antioxidant, Antimicrobial and Cytotoxic Activities of Different Fractions of Citrus aurantifolia Peel

CNS Depressant and Analgesic Activities of Thysanolaena maxima Roxb. Available in Bangladesh

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