A comparative study of biological potentiality and EAC cell growth inhibition activity of Phyllanthus acidus (L.) fruit pulp and seed in Bangladesh

Abstract

Highlights The screening of biological activities of medicinal plants are emphasized due to the adverse effects of synthetic drugs. The present study demonstrates antioxidant, cytotoxic, and haemagglutination activity as well as EAC cell growth inhibitory effect of methanolic extract of Phyllantus acidus (L.) (MEPA) fruit pulp and seed. P. acidus is traditionally used as herbal medicine in China, Brazil, and South Asian countries like Bangladesh for the treatment of digestive, respiratory, genitourinary, and skin disorder. The result of this study suggested that MEPA fruit pulp has a more antioxidant potentiality and EAC cell growth inhibitory property than seed which indicates the presence of effective phytochemicals in MEPA fruit pulp. Therefore, the MEPA fruit pulp can be considered as a promising biological source to search novel compounds for therapeutic purposes.

Flavonoid/Polyphenol Ratio in Mauritia flexuosa and Theobroma grandiflorum as an Indicator of Effective Antioxidant Action

“…This DPPH compound is a stable free radical when prepared in methanol. The free radical scavenging assay was implemented to test antioxidant action of polyphenols from both fruits according to methods described by Shimu et al, [31] and Yeddes et al [32] with slight modifications to optimize reactant volumes and reaction time. Volumes of 1900 µL of DPPH (100 µM) prepared in pure methanol were mixed with 100 µL of each diluted (1:5) extract and let react in the dark at room temperature for 30 min.…”