A comparative study of effects of dietary mercuric chloride and methylmercury chloride on growth performance, tissue accumulation, stress and immune responses, and plasma measurements in Korean rockfish, Sebastes schlegeli

Jang, Ji-Won; Lee, Seung-Hyung; Lee, Bong‐Joo; Hur, Sang‐Woo; Son, Maeng-Hyun; Kim, Kang‐Woong; Kim, Kyoung-Duck; Han, Hyon‐Sob

doi:10.1016/j.chemosphere.2020.127611

Cited by 14 publications

(10 citation statements)

References 42 publications

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“…Indeed, a toxicokinetic study of waterborne iHg in white seabream ( Diplodus sargus ) pointed out the gills as the most responsive organ by accumulating the metal faster than the other surveyed tissues/organs (eye wall, lens, blood, liver, brain, and bile), while accumulating the highest levels over the exposure time [ 11 ]. Moreover, a recent comparative study of dietary iHg and MeHg toxicity in the Korean rockfish ( Sebastes schlegeli ) comprised of the evaluation of Hg accumulation in several tissues (liver, kidney, dorsal muscle, and brain), reporting the highest levels in the liver upon exposure to MeHg [ 12 ]. This pattern was explained by the primary role of liver in detoxification that is related to metallothioneins or metallothionein-like proteins that bind specific metals (e.g., Hg, cadmium, copper) and sequester Hg ions [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Organ-Specific Metabolome Deciphering Cell Pathways to Cope with Mercury in Wild Fish (Golden Grey Mullet Chelon auratus)

Brandão

Pereira

Pacheco

et al. 2021

Animals

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Metabolomics is a powerful approach in evaluating the health status of organisms in ecotoxicological studies. However, metabolomics data reflect metabolic variations that are attributable to factors intrinsic to the environment and organism, and it is thus crucial to accurately evaluate the metabolome of the tissue/organ examined when it is exposed to no stressor. The metabolomes of the liver and gills of wild golden grey mullet (Chelon auratus) from a reference area were analyzed and compared by proton nuclear magnetic resonance (1H NMR)-based metabolomics. Both organs were characterized by amino acids, carbohydrates, osmolytes, nucleosides and their derivatives, and miscellaneous metabolites. However, similarities and differences were revealed in their metabolite profile and related to organ-specific functions. Taurine was predominant in both organs due to its involvement in osmoregulation in gills, and detoxification and antioxidant protective processes in liver. Environmental exposure to mercury (Hg) triggered multiple and often differential metabolic alterations in fish organs. Disturbances in ion-osmoregulatory processes were highlighted in the gills, whereas differential impairments between fish organs were pointed out in energy-producing metabolic pathways, protein catabolism, membrane stabilization processes, and antioxidant defense system, reflecting the induction of organ-specific adaptive and defensive strategies. Overall, a strict correlation between metabolites and organ-specific functions of fish gills and liver were discerned in this study, as well as organ-specific cytotoxicity mechanisms of Hg in fish.

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Section: Introductionmentioning

confidence: 99%

Organ-Specific Metabolome Deciphering Cell Pathways to Cope with Mercury in Wild Fish (Golden Grey Mullet Chelon auratus)

Brandão

Pereira

Pacheco

et al. 2021

Animals

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“…If these higher blood Hg concentrations translate to effects in wild snakes, it is unlikely that snakes in the Augusta population are currently at risk of immunosuppressive effects due to Hg exposure, as evidenced by their overall low blood THg concentrations (maximum value 0.582 mg/kg ww). It is important to consider that MeHg is typically more toxic to the vertebrate immune response relative to inorganic forms such as HgCl 2 (Desforges et al, 2016; Jang et al, 2020), and the majority of Hg in the blood in other reptiles is reported to be MeHg (turtles; Bergeron et al, 2007). We suspect that the differences in concentrations that inhibit proliferation in our studies may be due to the different species of Hg used, as well as the culture time that the lymphocytes were exposed to Hg in vitro.…”

Section: Discussionmentioning

confidence: 99%

Mercury immunotoxicity in the brown watersnake (Nerodia taxispilota): An in vitro study

Haskins

Brown

Meichner

et al. 2021

J of Applied Toxicology

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Mercury (Hg) is a heavy metal that enters the environment through natural and anthropogenic means. Once in the environment, Hg can biomagnify in food webs and is known to cause immunotoxic effects to wildlife. Compared with other vertebrates, knowledge of the reptilian immune system is lacking, especially in snakes. Further, even less is known about the impact of environmental contaminants on snake immunity. This gap in knowledge is largely due to an absence of established immune‐based assays or specific reagents for these species. In this study, brown watersnakes (Nerodia taxispilota; n = 23) were captured on the Savannah River (Augusta, Georgia, USA), weighed, measured, bled, and released. Peripheral blood leukocytes (24 h old) were enriched and evaluated with an established mammalian in vitro lymphocyte proliferation assay. Enriched leukocytes were then exposed to mercury chloride (HgCl2) at 3.75, 37.5, and 75 μM. Total mercury (THg) in whole blood was also quantified. Snake peripheral blood leukocyte enrichment yielded >90% lymphocytes with viabilities averaging >70%. Exposure to HgCl2 resulted in significant dose‐dependent suppression of proliferative responses relative to spontaneous proliferation at 37.5 and 75 μM (both p ≤ 0.01) but not 3.75 μM (p = 0.99). Mean ± 1 SE concentration of THg in whole blood was 0.127 ± 0.027 mg/kg (wet weight). Based on the in vitro findings with HgCl2, snakes in systems with heavy Hg pollution may be at risk of immunosuppression, but N. taxispilota at the site in this study appear to be at low risk.

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“…This could reflect the general higher toxicity of MeHg than inorganic Hg. 22 Similarly, dietary CH 3 HgCl uptake has been evidenced to have higher oxidative stress than HgCl 2 in Korean rockfish. 22 These altogether reflected the dependence of the Hg toxicity on its chemical form.…”

Section: Mercury and Methylmercury In Dongmenqiao Rivermentioning

confidence: 99%

“…22 Similarly, dietary CH 3 HgCl uptake has been evidenced to have higher oxidative stress than HgCl 2 in Korean rockfish. 22 These altogether reflected the dependence of the Hg toxicity on its chemical form. Methyl Hg can bind more efficiently to cysteine in fluids mimicking methionine membranes by amino acid transporters, which facilitates MeHg transport to tissues.…”

Section: Mercury and Methylmercury In Dongmenqiao Rivermentioning

confidence: 99%

Matrix in River Water, Sediments, and Biofilms Mitigates Mercury Toxicity to Medaka (Oryzias Latipes)

Jing,

Lin,

Tao

et al. 2023

Environ. Sci. Technol.

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A comparative study of effects of dietary mercuric chloride and methylmercury chloride on growth performance, tissue accumulation, stress and immune responses, and plasma measurements in Korean rockfish, Sebastes schlegeli

Cited by 14 publications

References 42 publications

Organ-Specific Metabolome Deciphering Cell Pathways to Cope with Mercury in Wild Fish (Golden Grey Mullet Chelon auratus)

Organ-Specific Metabolome Deciphering Cell Pathways to Cope with Mercury in Wild Fish (Golden Grey Mullet Chelon auratus)

Mercury immunotoxicity in the brown watersnake (Nerodia taxispilota): An in vitro study

Matrix in River Water, Sediments, and Biofilms Mitigates Mercury Toxicity to Medaka (Oryzias Latipes)

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