A comparative study of efficacy of oral itraconazole, terbinafine and fluconazole: a clinical trial

Abstract

<p class="abstract"><strong>Background:</strong> Keeping in view the rising number of cases of dermatophyte infections and also poor response to topical drugs, this study was conducted with the intention to arrive at a conclusion regarding the best available systemic drug.</p><p class="abstract"><strong>Methods:</strong> A total of 270 patients were selected for the study. 90 patients were assigned to each group under itraconazole, terbinafine & fluconazole.<strong></strong></p><p class="abstract"><strong>Results:</strong> It was found that itraconazole was the most effective drug which led to a considerable decrease in erythema, peripheral spread, scaling and spread to other body sites. Next drug to be the most effective was terbinafine, which was followed by fluconazole.</p><p class="abstract"><strong>Conclusions:</strong> We finally arrived at a conclusion that itraconazole is the most effective drug for all types of superficial fungal infections. It was followed by terbinafine & fluconazole in terms of drug effectiveness. Hence in this study we advocate the use of itraconazole as first line of drug in all patients of tinea infections.</p><p class="abstract"> </p>

A comparative study on efficacy of oral terbinafine and itraconazole on dermatophytic infections

“…7 A number of studies in the past have compared Itraconazole and Terbinafine for their efficacy in treatment of dermatophyte infection. [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] However, there is still controversy regarding the projection of better of these two modalities and what should be the appropriate drugdose regimen to obtain the optimum results with minimal adverse effects.…”

So Sánh Kết Quả Điều Trị Bệnh Nấm Thân Mình Bằng Uống Itraconazole Và Terbinafine Tại Bệnh Viện Da Liễu Trung Ương

“…Trong một nghiên cứu của Singh và cộng sự, khi so sánh Terbinafine (250 -500 mg/ngày trong 2 -6 tuần) và Itraconazole (100 -200 mg/ngày trong 2 -4 tuần), với các liều khác nhau, cũng cho kết quả là Itraconazole có hiệu quả hơn 15 . Một số nghiên cứu khác cũng cho thấy Itraconazole có hiệu quả cao hơn Terbinafine trong điều trị nấm thân mình 16,17,18 . Tuy nhiên, cũng có một số nghiên cứu chỉ ra rằng không có sự khác biệt giữa hai loại thuốc về hiệu quả điều trị, hoặc có một số nghiên cứu cho kết quả trái ngược, terbinafine có hiệu quả hơn Itraconazole 19,20 Hơn nữa, 10 chủng T. interdigitale (MIC 0,125 -2 μg/mL) có kiểu gen hoang dã.…”