A comparative study of epithelial cell proliferation between the odontogenic keratocyst, orthokeratinized odontogenic cyst, dentigerous cyst, and ameloblastoma

Abstract

These findings support previous studies that the proliferation indices are useful in predicting the different biological behavior of the odontogenic lesions and the OKC should be regarded as a benign tumor rather than simply an odontogenic cyst.

Cell proliferation and apoptosis in ameloblastomas and keratocystic odontogenic tumors

“…This is in accordance with previous reports (10,11). In contrast, studies have also demonstrated a higher cell proliferation in AM in relation to KOT (7)(8). All these authors used different methods to evaluate PI.…”

“…Since KOT had been classified as an odontogenic cyst, several authors have compared cell proliferation between KOT and odontogenic cysts (8,12,13). Although several authors have assessed cell proliferation and apoptosis in the odontogenic epithelium in AM and in the epithelial lining in KOT (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22), few studies have compared cell proliferation between these tumors (7,8,11) and no previous study has simultaneously evaluated cell proliferation and apoptotic indexes in AM and KOT, comparing both lesions. Therefore, this is the first study assessing comparatively cell proliferation and apoptosis indexes in AM and KOT, although tissue cell population is controlled by a balance among these processes.…”

“…A higher proliferation activity in AM epithelium in relation to KOT epithelial lining has been demonstrated (7)(8)(9), even though opposite results have also been reported (10,11). Several studies have evaluated apoptosis and related apoptotic factors in the odontogenic epithelium of AM and epithelial lining of KOT (10)(11)(12)(13)(14)(15)(16)(17)(18)(19).…”

Multiple Orthokeratinized Odontogenic Cysts: A Case Report

“…Prominent palisaded and hyperchromatic nuclei in the basal cell layer are not seen in OOC. Many studies have also found different histochemical and immunohistochemical features in OOC from OKC, including significant differences in keratin profiles in the cyst lining epithelium [10], in collagen fibers, fibronectin, or numbers of myofibroblasts in the cyst wall [11][12][13][14], in expression of podoplanin [15], Ki-67, p63 [3], TGF-a, P53 [16], bcl-2 [17], KAI-1 [18], cell proliferating marker IPO-38 [19], calretinin [20], EMA, CEA, and involucrin [21]. These findings lead to the current concept that OOC is a different pathological entity from OKC.…”

Odontogenic Epithelium: Immunolabeling of Ki-67, EGFR and Survivin in Pericoronal Follicles, Dentigerous Cysts and Keratocystic Odontogenic Tumors

“…The average number of cells positive for Ki-67 in KOTs, DCs and PFs in this study was in line with values reported in the literature. KOTs presented the greatest proliferation rate among the three groups, with Ki-67 immunolabeling found mainly in the suprabasal layer, suggesting an altered cell cycle and indicating the presence of a suprabasal proliferative compartment [7,22,[30][31][32][33][34]. In DCs, the basal layer was found to be the proliferative compartment [34,35].…”