A comparative study of Ferula hermonis root extracts and sildenafil on copulatory behaviour of male rats

Hadidi, K.; Aburjai, Talal; Battah, Arwa

doi:10.1016/s0367-326x(03)00032-7

Cited by 52 publications

(32 citation statements)

References 16 publications

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“…[13][14][15] A recent systematic review of randomized clinical trials revealed that Panax ginseng improves glucose metabolism and moderates the immune response. 16 KRG is also used as a tonic to maintain physical vitality and for restorative purposes throughout East Asian countries, including Korea and China.…”

Section: Discussionmentioning

confidence: 99%

Effects of Korean ginseng berry extract (GB0710) on penile erection: evidence from in vitro and in vivo studies

Park¹,

Kim²,

Jeon³

et al. 2013

Asian J Androl

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Several reports have promoted the root-derived Korean red ginseng (KRG; Panax ginseng) as alternative treatment for erectile dysfunction (ED), and ginsenosides are known to be the principal active ingredients of ginseng. Recent studies showed that ginseng berries produce more ginsenosides than KRG; thus, we investigated the ability of the Korean ginseng berry extract GB0710 to relax the penile corpus cavernosum smooth muscle (CCSM) in this study. As a comparative control, the results were compared to those obtained using KRG. In addition, possible mechanisms of action for GB0710 were investigated. While KRG and GB0710 both displayed dose-dependent relaxation effects on precontracted rabbit CCSM in vitro, GB0710 was shown to be more potent than KRG. The GB0710-induced relaxation could be partially reduced by removing the endothelium. In addition, pre-treatment with several nitric oxide (NO) inhibitors significantly inhibited the relaxation of muscle strips. Furthermore, administration of GB0710 increased intracavernosal pressure (ICP) in a rat in vivo model in both a dose-and duration-dependent manner. Intracellular NO production in human microvascular endothelial cells could be induced by GB0710 and inhibited by N G -monomethyl-L-arginine. In conclusion, GB0710 had a greater relaxation effect on rabbit CCSM than did KRG extract, and increased ICP in a rat model in both a dose-and a duration-dependent manner. This relaxing effect might be mediated by NO production. Keywords: corpus cavernosum; erectile dysfunction (ED); ginseng berry; nitric oxide (NO); smooth muscle INTRODUCTION Erectile dysfunction (ED) is defined as the inability to attain or maintain penile erection sufficient for satisfactory sexual intercourse. ED is a common condition in middle-aged men that has serious adverse effects on quality of life. It has been reported that approximately 50% of men aged 40-80 years suffer from ED to some degree. 1 One of the etiological causes of ED is the reduced bioavailability of nitric oxide (NO). This causes insufficient relaxation of smooth muscle in the penile corpus cavernosum, leading to a subsequently insufficient inflow of blood. Several extensive studies have investigated the positive effects of ginseng on ED, thereby implicating the NO pathway as the mechanism of action. 2,3 Among these, various reports have promoted the root-derived Korean red gingseng (KRG; Panax ginseng) as alternative treatment for ED, citing the stimulatory effect of KRG on the corpus cavernosum smooth muscle (CCSM) of the penis. [4][5][6] The principal active ingredients of ginseng are ginsenosides (also called ginseng saponins), which are amphiphilic molecules comprised of an aglycon backbone (a hydrophobic four-ring steroid-like structure) linked to hydrophilic carbohydrate side chains that consist of monomers, dimers and tetramers. 5,7 Ginsenoside is widely and variably distributed thoughout the ginseng plant. 8 Kim et al. 9 investigated the ginsenoside content of Korean ginseng, indicating ginseng berries (GB) and ginseng r...

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Section: Discussionmentioning

confidence: 99%

Effects of Korean ginseng berry extract (GB0710) on penile erection: evidence from in vitro and in vivo studies

Park¹,

Kim²,

Jeon³

et al. 2013

Asian J Androl

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“…3 It is noteworthy, however, that depending on the type of solvent used for the extraction procedure, F. hermonis exerted different effects on male rat sexual activity. 4 In fact, it has been described that the methanolic extract significantly increased the number of mounts, in comparison with controls, while water, petroleum ether and ethyl acetate extracts significantly increased intromission latency. In addition, the last two extracts decreased the number of mounts and intromissions.…”

Section: Introductionmentioning

confidence: 99%

“…The authors suggested that F. hermonis components with low polarity (usually extracted with nonpolar solvents) decrease sexual activity in male rats, while compounds with higher polarity (usually extracted with polar solvents) exert a stimulatory effect on sexual motivation. 4 We recently studied the influence of an acetonic extract of F. hermonis on the copulatory behavior of experienced male rats. The acute oral administration of the extract stimulated sexual motivation in potent rats (30 and 60 mg/kg) and improved copulatory performance in sluggish/impotent rats (60 mg/ kg) in parallel with increased testosterone serum levels.…”

Section: Introductionmentioning

confidence: 99%

Activity of single components of Ferula hermonis on male rat sexual behavior

et al. 2005

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The influence of the single components of Ferula hermonis extract on sexual behavior was studied in male rats. Sexually potent and sluggish/impotent animals were orally treated acutely (2.5 mg/kg) and subchronically (0.25 mg/kg/day for 10 days) with ferutinin, teferdin and teferin. Ferutinin alone acutely administered in potent rats was able to reduce mount and intromission latencies, while in sluggish/impotent animals, it induced the same effects and additionally shortened the ejaculation latency, as teferdin did. Both substances increased testosterone levels in rats. Unlike teferdin, ferutinin subchronically administered in potent rats negatively affected appetitive and consummatory sexual behavior, reducing also testosterone serum levels. In conclusion, if repetitively administered, ferutinin was able to stimulate sexual behavior after acute ingestion, but exerted a negative influence on the sexual capacity of potent male rats, whereas teferdin only improved copulatory performance of sluggish/impotent animals.

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“…Many herbalists of the Middle East, indicate that this plant has a strong aphrodisiac and anti-impotence activity being promoted as an alternative to Viagra ® . Recent studies have shown that the extract of the root of Ferula hermonis, increases the sexual activity of male rats (Hadidi et al, 2003). In previous studies on roots of Ferula hermonis, several sesquiterpene have been isolated, most of which display biological activities (Ahmed, 1990).…”

Section: Introductionmentioning

confidence: 99%

Ferutinin stimulates nitric oxide synthase activity in median eminence of the rat

Colman-Saizarbitoria

Boutros

Amesty

et al. 2006

Journal of Ethnopharmacology

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A comparative study of Ferula hermonis root extracts and sildenafil on copulatory behaviour of male rats

Cited by 52 publications

References 16 publications

Effects of Korean ginseng berry extract (GB0710) on penile erection: evidence from in vitro and in vivo studies

Effects of Korean ginseng berry extract (GB0710) on penile erection: evidence from in vitro and in vivo studies

Activity of single components of Ferula hermonis on male rat sexual behavior

Ferutinin stimulates nitric oxide synthase activity in median eminence of the rat

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