A comparative study of flavonoid analogues on streptozotocin–nicotinamide induced diabetic rats: Quercetin as a potential antidiabetic agent acting via 11β-Hydroxysteroid dehydrogenase type 1 inhibition

Torres‐Piedra, Mariana; Ortíz-Andrade, Rolffy; Villalobos‐Molina, Rafael; Singh, Narender; Medina‐Franco, José L.; Webster, Scott P.; Binnie, Margaret; Navarrete‐Vázquez, Gabriel; Estrada‐Soto, Samuel

doi:10.1016/j.ejmech.2010.02.049

Cited by 118 publications

(68 citation statements)

References 25 publications

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“…We also found that the main components of the extracts are flavons and flavonols. These compounds are known to produce hypoglycemic effects, as previously demonstrated by Torres-Piedra et al (2010). Altogether, the results of the present study demonstrate the hypoglycemic effects of BP and support the traditional use of the plant for the treatment of T2D.…”

Section: Discussionsupporting

confidence: 67%

Hypoglycemic Effect of Bromelia plumieri (E. Morren) L.B. Sm., leaves in STZ-NA-Induced Diabetic Rats

Andrade‐Cetto¹,

Medina-Hernández²

2013

Planta Med

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This study confirms the hypoglycemic effects of two extracts obtained from the Bromelia plumieri (BP) plant in streptozotocin-nicotinamide-induced diabetic rats (STZ-NA). BP has been traditionally used in the municipality of Tlanchinol Hidalgo, Mexico, to treat type 2 diabetes. Two different BP extracts were prepared and tested. The first extract was a water extract (WE), similar to that traditionally used to make tea, and the second extract was an ethanol:water extract (EWE). The extracts (WE at 35 and 350 mg/kg, and EWE at 30 and 300 mg/kg) were tested in STZ-NA-induced diabetic rats to determine whether hypoglycemia occurred after oral administration of the extracts. Phytochemistry: Two different extracts were prepared, n-hexane and butanol, to determine the presence of alkaloids, terpenes and flavonoids. The extracts that were administered to the STZ-NAinduced diabetic rats produced a significant hypoglycemic effect as compared with the control group, similar to that achieved with glibenclamide. We also determined that flavonoids were the main components of BP leaves. The results presented here support the hypothesis that extracts obtained from this plant have hypoglycemic effects, which are in agreement with the traditional uses of this plant.

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Section: Discussionsupporting

confidence: 67%

Hypoglycemic Effect of Bromelia plumieri (E. Morren) L.B. Sm., leaves in STZ-NA-Induced Diabetic Rats

Andrade‐Cetto¹,

Medina-Hernández²

2013

Planta Med

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“…There are few examples applying 3-HF to animal models. Recently, 3-HF was injected to diabetic rats as 50 mg/kg dose and showed effective result on acute in vivo hypoglycemic and antidiabetic activities [34]. 3-HF was also applied to parasite-infected BALB/c mice to observe antiprotozoal activity (total dose of 200 mg/kg).…”

Section: Discussionmentioning

confidence: 99%

Combined treatment of 3-hydroxyflavone and imatinib mesylate increases apoptotic cell death of imatinib mesylate-resistant leukemia cells

et al. 2012

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“…Potential inhibitors for 11β-hydroxysteroid dehydrogenase-1 were also sought out in flavonoid compounds. Torres-Piedra et al (2010) tested several flavonoids on human embryonic kidney (HEK293) cells and found that quercetin and flavone had inhibitory effects on the 11β-hydroxysteroid dehydrogenase-1 enzyme. The effect is thought to be related to the interaction with the catalytic active site of 11β-hydroxysteroid dehydrogenase-1.…”

Section: Discussionmentioning

confidence: 99%

Plants and Natural Compounds with Antidiabetic Action

Coman

Rugină

Socaciu

2012

Not Bot Hort Agrobot Cluj

132

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Diabetes has become the most common metabolic disease worldwide. In particular, type 2 diabetes is the most commonly encountered type of diabetes, which is characterised by the inability of the organism to respond to normal levels of circulating insulin, also called insulin resistance. Current antidiabetic therapy is based on synthetic drugs that very often have side effects. For this reason, there is a continuous need to develop new and better pharmaceuticals as alternatives for the management and treatment of the disease. Natural hypoglycaemic compounds may be attractive alternatives to synthetic drugs or reinforcements to currently used treatments. Their huge advantage is that they can be ingested in everyday diet. Recently, more attention is being paid to the study of natural products as potential antidiabetics. This mini review of the current literature is structured into three main sections focused on: (a) plant extracts, (b) plant biomolecules, and (c) other natural molecules that have been used for their antidiabetic effects. Potential molecular mechanisms of action are also discussed.

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A comparative study of flavonoid analogues on streptozotocin–nicotinamide induced diabetic rats: Quercetin as a potential antidiabetic agent acting via 11β-Hydroxysteroid dehydrogenase type 1 inhibition

Cited by 118 publications

References 25 publications

Hypoglycemic Effect of Bromelia plumieri (E. Morren) L.B. Sm., leaves in STZ-NA-Induced Diabetic Rats

Hypoglycemic Effect of Bromelia plumieri (E. Morren) L.B. Sm., leaves in STZ-NA-Induced Diabetic Rats

Combined treatment of 3-hydroxyflavone and imatinib mesylate increases apoptotic cell death of imatinib mesylate-resistant leukemia cells

Plants and Natural Compounds with Antidiabetic Action

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