A comparative study of hard gelatin and hypromellose capsules containing a dry extract of senna (Cassia angustifolia) under controlled temperature and relative humidity.

Araújo, Renata Lázara de; Soares, Maria Elisa; Mazzei, José Luiz; Siani, AC

doi:10.36468/pharmaceutical-sciences.700

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…Until today the evolution of technology and performance of the cDPI systems continues, whereby gelatin capsules are still leading the market due to the ease and availability of capsule filling [ 51 ]. Compared to hard gelatin capsules, the recently introduced HPMC capsules have been demonstrated to have several advantages such as requiring less force for shell puncture [ 52 , 53 , 54 ] which results in a more regular aperture and less shedding of pieces [ 55 ]. This has been correlated to an improved delivered dose, fine particles dose, and less powder retention in the HPMC capsules relative to gelatin capsules [ 56 ].…”

Section: Critical Materials Attributes (Cmas) In Cdpismentioning

confidence: 99%

A Quality by Design Framework for Capsule-Based Dry Powder Inhalers

et al. 2021

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Capsule-based dry powder inhalers (cDPIs) are widely utilized in the delivery of pharmaceutical powders to the lungs. In these systems, the fundamental nature of the interactions between the drug/formulation powder, the capsules, the inhaler device, and the patient must be fully elucidated in order to develop robust manufacturing procedures and provide reproducible lung deposition of the drug payload. Though many commercially available DPIs utilize a capsule-based dose metering system, an in-depth analysis of the critical factors associated with the use of the capsule component has not yet been performed. This review is intended to provide information on critical factors to be considered for the application of a quality by design (QbD) approach for cDPI development. The quality target product profile (QTPP) defines the critical quality attributes (CQAs) which need to be understood to define the critical material attributes (CMA) and critical process parameters (CPP) for cDPI development as well as manufacturing and control.

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Section: Critical Materials Attributes (Cmas) In Cdpismentioning

confidence: 99%

A Quality by Design Framework for Capsule-Based Dry Powder Inhalers

et al. 2021

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“…For example, acetate cellulose, an insoluble derivative, is frequently utilized to provide a sustained drug release profile [ 12 , 13 , 14 ]. In sharp contrast, HPMC, as a water-soluble drug, is a popular drug carrier for ensuring the fast dissolution of poorly water-soluble drugs [ 15 , 16 , 17 , 18 ]. Meanwhile, these derivatives can be combined with other synthetic polymers to offer multiple-phase drug controlled-release profiles, such as the typical double-phase release that includes an initial, immediate release for easing patient symptoms and a later, sustained release for the sake of reduced administration time [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Electrospun Core (HPMC–Acetaminophen)–Shell (PVP–Sucralose) Nanohybrids for Rapid Drug Delivery

Liu

Zhang

Song

et al. 2022

Gels

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The gels of cellulose and its derivatives have a broad and deep application in pharmaceutics; however, limited attention has been paid to the influences of other additives on the gelation processes and their functional performances. In this study, a new type of electrospun core–shell nanohybrid was fabricated using modified, coaxial electrospinning which contained composites of hydroxypropyl methyl cellulose (HPMC) and acetaminophen (AAP) in the core sections and composites of PVP and sucralose in the shell sections. A series of characterizations demonstrated that the core–shell hybrids had linear morphology with clear core–shell nanostructures, and AAP and sucralose distributed in the core and shell section in an amorphous state separately due to favorable secondary interactions such as hydrogen bonding. Compared with the electrospun HPMC–AAP nanocomposites from single-fluid electrospinning of the core fluid, the core–shell nanohybrids were able to promote the water absorbance and HMPC gelation formation processes, which, in turn, ensured a faster release of AAP for potential orodispersible drug delivery applications. The mechanisms of the drug released from these nanofibers were demonstrated to be a combination of erosion and diffusion mechanisms. The presented protocols pave a way to adjust the properties of electrospun, cellulose-based, fibrous gels for better functional applications.

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A comparative study of hard gelatin and hypromellose capsules containing a dry extract of senna (Cassia angustifolia) under controlled temperature and relative humidity.

Cited by 2 publications

References 7 publications

A Quality by Design Framework for Capsule-Based Dry Powder Inhalers

A Quality by Design Framework for Capsule-Based Dry Powder Inhalers

Electrospun Core (HPMC–Acetaminophen)–Shell (PVP–Sucralose) Nanohybrids for Rapid Drug Delivery

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