A comparative study of insertion/deletion polymorphisms applied among Southwest, South and Northwest Chinese populations using Investigator® DIPplex

Wang, Li; Lv, Meili; Zaumsegel, D.; Zhang, Lushun; Feng-ji, Liu; Xiang, Jihua; Li, Jun; Schneider, Peter M.; Liang, Weibo; Zhang, Lin

doi:10.1016/j.fsigen.2015.08.005

Cited by 32 publications

(21 citation statements)

References 30 publications

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“…The CPE values were 0.9861, 0.9968, 0.9957, 0.9975, 0.9884, 0.9900 in the previously published Dong, Uyghur1 [22], Tibetan, Uyghur [17], Taiwanese, Poles [28], respectively. And we could observe that the CPE of 30 Indel loci in various populations changed within a narrow scope.…”

Section: Discussionmentioning

confidence: 71%

“…Guangdong Han [11], Shanghai Han [12], Yi [13], Xibe [14], South Korean [15], She [16], Beijing Han, Tibetan, Kazak, Uyghur [17], Dane [18], Hungarian [19], Basque, Central Spanish [20], Uruguayan [21], Uyghur1, Zhuang, Dong, Miao, Chengdu Han, Tibetan1 [22], Henan Han, Beijing Han1, Uyghur2, Tibetan2 [23], the population structure of Bai ethnic group was performed by the structure program. In the determination of K value (Supplementary Figure 1), the results of L( K ) showed that K =3, 4 depicted a plateau obviously.…”

Section: Resultsmentioning

confidence: 99%

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Genetic variation and forensic efficiency of autosomal insertion/deletion polymorphisms in Chinese Bai ethnic group: phylogenetic analysis to other populations

et al. 2017

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Thirty insertion/deletion loci were utilized to study the genetic diversities of 125 bloodstain samples collected from Bai group in Yunnan Dali region, China. The observed heterozygosity and expected heterozygosity of the 30 loci ranged from 0.1520 to 0.5680, and 0.1927 to 0.4997, respectively. No deviations from Hardy-Weinberg equilibrium tests after Bonferroni correction were found at all 30 loci in Bai group. The cumulative probability of exclusion and combined discrimination power were 0.9859 and 0.9999999999887, respectively, which indicated the 30 loci could be used as complementary genetic markers for paternity testing and were qualified for personal identification in forensic cases. We found the studied Bai group had close relationships with Tibetan, Yi and Han groups from China by the population structure, principal component analysis, population differentiations, and phylogenetic reconstruction studies. Even so, for a better understanding of Bai ethnicity's genetic milieu, DNA genotyping at various genetic markers is necessary in future studies.

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Section: Discussionmentioning

confidence: 71%

Section: Resultsmentioning

confidence: 99%

Genetic variation and forensic efficiency of autosomal insertion/deletion polymorphisms in Chinese Bai ethnic group: phylogenetic analysis to other populations

et al. 2017

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“…To comprehensively explore the patterns of genetic affinity between our studied populations and worldwide reference populations, we merged our newly obtained population data with those of 61 worldwide populations. The final database used in the population comparison study included 6483 East Asian individuals from 38 populations [4,5,[8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26], 494 South Asians from three populations [27][28][29], 300 Vietnamese of Southeast Asia [30], 194 West Asians from two populations [31], 621 African individuals from five populations [27,30,32], 984 European individuals from eight populations [4,[31][32][33][34][35] and 1 071 South Americans from eight populations [36,38]. The detailed geographical regions and population sizes of these included populations are submitted in Supplementary Table S1.…”

Section: Reference Databasementioning

confidence: 99%

Population Genetics and Forensic Efficiency of 30 InDel Markers in Four Chinese Ethnic Groups Residing in Sichuan

Wang

et al. 2020

Forensic Sciences Research

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Sichuan Province is located at the transitional junction regions of the Qinghai-Tibet Plateau and the low-altitude plains. It also serves as the corridor of Sino-Tibetan-speaking population migration and expansion since neolithic expansion of Proto-Tibeto-Burman populations from Middle/Upper Yellow River during Majiayao period (3300-2000 BC). However, the population structure and the corresponding genetic diversity of forensic-related markers in this region remain unclear. Thus, we genotyped 30 insertion-deletion (InDel) markers in 444 samples from four ethnic groups (Han, Tibetan, Hui and Yi) from Sichuan Province using the Investigator V R DIPplex kit to explore the characteristics of population genetics and forensic genetic focuses. All the loci were found to be in Hardy-Weinberg Equilibrium (HWE) after applying a Bonferroni correction and no pairwise loci showed prominent linkage disequilibrium. The combined matching probability (CMP) and the combined power of discrimination (CPD) are larger than 1.8089 Â 10 À11 and 0.99999999995, respectively. Principal component analysis, Multi-Dimensional Scaling Plots and Neighbour-Joining tree among 65 worldwide populations indicated that Sichuan Hui and Han are genetically close to Hmong-Mien and Tai-Kadai-speaking populations, and Sichuan Tibetan and Yi bear a strong genetic affinity with Tibeto-Burmanspeaking populations. The model-based genetic structure further supports the genetic affinity between the studied populations and linguistically close populations. KEY POINTSForensic parameters of 30 insertion-deletions (InDels) in 444 individuals from four populations are reported, which showed abundant genetic affinity and diversity among populations and high value in personal identification. Genetic similarities existed between the studied populations and ethnically, linguistically close populations. Sichuan Hui and Han are genetically close to Hmong-Mien and Tai-Kadai-speaking populations. Sichuan Tibetan and Yi bear a strong genetic affinity with Tibeto-Burman-speaking populations. ARTICLE HISTORY

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“…When comparing the studied 38 indel set with the 30 indel set commercially available in the Investigator ® DIPplex Kit (Qiagen, Hilden, Germany), accumulated PD values were about two orders of magnitude higher in population samples from Spain, Iraq, Brazil, and Uruguay [33][34][35][36], and three orders of magnitude higher in populations from México, South Africa, and East Asia [17,[37][38][39]. These results support previous findings showing higher forensic information content of the 38 indel panel compared to the Investigator ® DIPplex Kit in US African American, Caucasian, East Asian, and Hispanic samples [40] (see Supplementary Table 8 for details).…”

Section: Forensically Relevant Parametersmentioning

confidence: 99%

A GHEP-ISFG collaborative study on the genetic variation of 38 autosomal indels for human identification in different continental populations

Pereira

Alves

Aler

et al. 2018

Forensic Science International: Genetics

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A collaborative effort was carried out by the Spanish and Portuguese Speaking Working Group of the International Society for Forensic Genetics (GHEP-ISFG) to promote knowledge exchange between associate laboratories interested in the implementation of indel-based methodologies and build allele frequency databases of 38 indels for forensic applications. These databases include populations from different countries that are relevant for identification and kinship investigations undertaken by the participating laboratories. Before compiling population data, participants were asked to type the 38 indels in blind samples from annual GHEP-ISFG proficiency tests, using an amplification protocol previously described. Only laboratories that reported correct results contributed with population data to this study. A total of 5839 samples were genotyped from 45 different populations from Africa, America, East Asia, Europe and Middle East. Population differentiation analysis showed significant differences between most populations studied from Africa and America, as well as between two Asian populations from China and East Timor. Low F values were detected among most European populations. Overall diversities and parameters of forensic efficiency were high in populations from all continents.

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A comparative study of insertion/deletion polymorphisms applied among Southwest, South and Northwest Chinese populations using Investigator® DIPplex

Cited by 32 publications

References 30 publications

Genetic variation and forensic efficiency of autosomal insertion/deletion polymorphisms in Chinese Bai ethnic group: phylogenetic analysis to other populations

Genetic variation and forensic efficiency of autosomal insertion/deletion polymorphisms in Chinese Bai ethnic group: phylogenetic analysis to other populations

Population Genetics and Forensic Efficiency of 30 InDel Markers in Four Chinese Ethnic Groups Residing in Sichuan

A GHEP-ISFG collaborative study on the genetic variation of 38 autosomal indels for human identification in different continental populations

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