A Comparative Study of Insulin Resistance in Offsprings of Type 2 Diabetes Mellitus and Non Diabetic Patients, a One Year Cross Sectional Hospital Based Study

Abstract

OBJECTIVE: To assess the insulin resistance in offspring's of type 2 diabetes mellitus patients, with off springs of non-diabetic patients. METHODOLOGY: The study included offspring's of 30 diabetic and 30 non-diabetic patients with a proper clinical examination according to predesigned and pretested proforma. Mean age, insulin levels, Homeostasis model assessment-insulin resistance (HOMA-IR) and BMI of the two groups were compared using unpaired't' test. Chi-square test and Kruskal Wallis test were used to test the association between two or more variables in case of frequency distribution. RESULTS: It was observed that the offspring's in case group had higher insulin levels compared to control group. Insulin resistance was found to be 48.5% in case group and 19.4% in control group which was considered is statistically significant (p=0.009). Insulin resistance was seen in 47.05% offspring's whose fathers were a diabetic, 41.6% offspring's whose mother were a diabetic and 66.6% offspring's had history of both parents being diabetic. However, the p value was not statistically significant (p=0.597).