A comparative study of microporous polyolefin silica-based paper and cellulose paper substrates utilizing paper spray-mass spectrometry in drug analysis

Silva, Imesha W. De; Converse, Darren T.; Juel, Lauren A.; Verbeck, Guido F.

doi:10.1039/c9ay00641a

Cited by 13 publications

(10 citation statements)

References 30 publications

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“…Papers were cut into triangular substrates with rounded lower corners using a universal laser cutter to create substrates with a base of 8 mm and height of 10 mm, leading to a spray tip angle of ∼45°. Other geometries and substrates were tested; however, a rigorous evaluation is not presented here, as other works have characterized the impact of the spray tip angle and substrates on PS-MS performance. − Paper substrates were mounted in a stainless steel alligator clip, and a voltage of −3 to −5 kV was applied to the solvent-soaked substrate. The solvent (either HPLC grade methanol or a methanol–chloroform mixture) was continuously supplied to the underside of the substrate with a PEEK delivery tube connected to a syringe pump operating at 20–30 μL min –1 .…”

Section: Methodsmentioning

confidence: 99%

Combining Mass Spectrometry of Picoliter Samples with a Multicompartment Electrodynamic Trap for Probing the Chemistry of Droplet Arrays

2020

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Single droplet levitation provides contactless access to the microphysical and chemical properties of micron-sized samples. Most applications of droplet levitation to chemical and biological systems use non-destructive optical techniques to probe droplet properties. To provide improved chemical specificity, we couple a multi-compartment quadrupole electrodynamic trap (QET) to single droplet mass spectrometry. Our QET continuously traps a monodisperse droplet population (∼10's -100's of droplets), and allows for simultaneous sizing of a single droplet using its Mie scattering pattern. Single droplets are subsequently ejected to the ionization region of an ambient pressure inlet mass spectrometer. We optimize two complementary soft ionization techniques for picoliter aqueous droplets: paper spray (PS) ionization and thermal desorption glow discharge (TDGD) ionization. Both techniques detect oxygenated organic acids in single droplets with signal-to-noise ratios >100 and detection limits on the order of

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Section: Methodsmentioning

confidence: 99%

Combining Mass Spectrometry of Picoliter Samples with a Multicompartment Electrodynamic Trap for Probing the Chemistry of Droplet Arrays

2020

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“…As an alternative, another substrate, Teslin ® , was used for the PSI experiments, which allowed HBIW to be detected after the desired reaction time. Cellulose based paper substrates, such as Whatman 1 filter paper, are hydrophilic and have larger pore sizes compared to the Teslin ® substrate which is microporous and hydrophobic 54 , 55 . The reaction mixture was retained on the surface of the Teslin ® substrate due to its hydrophobicity allowing the reaction to occur in the thin film formed on the surface rather than diffusing into the paper when using the Whatman 1 filter paper and reacting in the pores.…”

Section: Resultsmentioning

confidence: 99%

Accelerated synthesis of energetic precursor cage compounds using confined volume systems

Brown

Doppalapudi

Fedick

2021

Sci Rep

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Confined volume systems, such as microdroplets, Leidenfrost droplets, or thin films, can accelerate chemical reactions. Acceleration occurs due to the evaporation of solvent, the increase in reactant concentration, and the higher surface-to-volume ratios amongst other phenomena. Performing reactions in confined volume systems derived from mass spectrometry ionization sources or Leidenfrost droplets allows for reaction conditions to be changed quickly for rapid screening in a time efficient and cost-saving manner. Compared to solution phase reactions, confined volume systems also reduce waste by screening reaction conditions in smaller volumes prior to scaling. Herein, the condensation of glyoxal with benzylamine (BA) to form hexabenzylhexaazaisowurtzitane (HBIW), an intermediate to the highly desired energetic compound 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20), was explored. Five confined volume systems were compared to evaluate which technique was ideal for forming this complex cage structure. Substituted amines were also explored as BA replacements to screen alternative cage structure intermediates and evaluate how these accelerated techniques could apply to novel reactions, discover alternative reagents to form the cage compound, and improve synthetic routes for the preparation of CL-20. Ultimately, reaction acceleration is ideal for predicting the success of novel reactions prior to scaling up and determining if the expected products form, all while saving time and reducing costs. Acceleration factors and conversion ratios for each reaction were assessed by comparing the amount of product formed to the traditional bulk solution phase synthesis.

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“…In this work, Teslin ® synthetic paper, which composed of micro-porous polyolefin-silica matrix was used as a substrate for depositing sample containing solution droplet. Compared with commonly used cellulose paper, previous work by the authors has indicated that Teslin ® paper allowed the samples to have a larger active signal, resulting in a higher amount of ion formation, and with less interference of molecules from the substrate ( De Silva et al, 2019 ). By comparing with standard RT-PCR tests, the mass spectrometry method achieved a 93.3% sensitivity with an analyzing time of 1 min.…”

Section: Application Of Paper-based Poc Tests For Covid-19mentioning

confidence: 99%

Paper-Based Point-of-Care Testing of SARS-CoV-2

Yuan

Sun

Tian

et al. 2021

Front. Bioeng. Biotechnol.

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The COVID-19 pandemic has resulted in significant global social and economic disruption. The highly transmissive nature of the disease makes rapid and reliable detection critically important. Point-of-care (POC) tests involve performing diagnostic tests outside of a laboratory that produce a rapid and reliable result. It therefore allows the diagnostics of diseases at or near the patient site. Paper-based POC tests have been gaining interest in recent years as they allow rapid, low-cost detection without the need for external instruments. In this review, we focus on the development of paper-based POC devices for the detection of SARS-CoV-2. The review first introduces the principles of detection methods that are available to paper-based devices. It then summarizes the state-of-the-art paper devices and their analytical performances. The advantages and drawbacks among methods are also discussed. Finally, limitations of the existing devices are discussed, and prospects are given with the hope to identify research opportunities and directions in the field. We hope this review will be helpful for researchers to develop a clinically useful and economically efficient paper-based platform that can be used for rapid, accurate on-site diagnosis to aid in identifying acute infections and eventually contain the COVID-19 pandemic.

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A comparative study of microporous polyolefin silica-based paper and cellulose paper substrates utilizing paper spray-mass spectrometry in drug analysis

Abstract: This comparative study proposes an efficient technique by employing a synthetic substrate, which is commercially available, for direct, sensitive, efficient and fast analysis in Paper Spray Mass Spectrometry (PS-MS).

Cited by 13 publications

References 30 publications

Combining Mass Spectrometry of Picoliter Samples with a Multicompartment Electrodynamic Trap for Probing the Chemistry of Droplet Arrays

Combining Mass Spectrometry of Picoliter Samples with a Multicompartment Electrodynamic Trap for Probing the Chemistry of Droplet Arrays

Accelerated synthesis of energetic precursor cage compounds using confined volume systems

Paper-Based Point-of-Care Testing of SARS-CoV-2

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