A comparative study of optimized naringenin nanoformulations using nano-carriers (PLA/PVA and zein/pectin) for improvement of bioavailability

Smruthi, M. R.; Nallamuthu, Ilaiyaraja; Anand, T.

doi:10.1016/j.foodchem.2021.130950

Cited by 45 publications

(14 citation statements)

References 39 publications

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“…Nag-loaded PLA/PVA NPs (Nag-P/P NPs) with an average size from 147 to 409 nm and encapsulation efficiency from 22.1 to 80.4%, depending on the percentage of the three compounds, were prepared by solvent evaporation method [ 143 ]. Nag-loaded Zein/pectin NPs (Nag-Z/P) with a mean particle size from 185 to 403 nm and encapsulation efficiency from 19.5 to 68.9%, depending on the pectin concentration and pH of the system, was prepared through anti-solvent precipitation and electrostatic deposition method.…”

Section: Flavonoid-loaded Polymeric Systemsmentioning

confidence: 99%

“…The maximum plasma concentration and its relative bioavailability were higher for NPs treated rats in comparison with free Nag-treated rats. Nag-P/P NPs showed a higher relative bioavailability in comparison with Nag-Z/P NPs, likely because of the increased mucoadhesive properties of the second one [ 143 ].…”

Section: Flavonoid-loaded Polymeric Systemsmentioning

confidence: 99%

“… ( A ) SEM image of Nag-P/P and Nag-Z/P NPs; ( B ) release profile of Nag-loaded nanoformulations at different digestion phases (simulated salivary fluid (SSF): 0–10 min; simulated gastric fluid (SGF): 10–120 min; simulated intestinal fluid (SIF): 120–300 min; ( C ) plasma concentration-time profile for the different Nag-loaded formulations. Reproduced with permission from [ 143 ], Elsevier, 2022. …”

Section: Figurementioning

confidence: 99%

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Polymeric Systems for the Controlled Release of Flavonoids

2023

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Flavonoids are natural compounds that are attracting great interest in the biomedical field thanks to the wide spectrum of their biological properties. Their employment as anticancer, anti-inflammatory, and antidiabetic drugs, as well as for many other pharmacological applications, is extensively investigated. One of the most successful ways to increase their therapeutic efficacy is to encapsulate them into a polymeric matrix in order to control their concentration in the physiological fluids for a prolonged time. The aim of this article is to provide an updated overview of scientific literature on the polymeric systems developed so far for the controlled release of flavonoids. The different classes of flavonoids are described together with the polymers most commonly employed for drug delivery applications. Representative drug delivery systems are discussed, highlighting the most common techniques for their preparation. The flavonoids investigated for polymer system encapsulation are then presented with their main source of extraction and biological properties. Relevant literature on their employment in this context is reviewed in relationship to the targeted pharmacological and biomedical applications.

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Section: Flavonoid-loaded Polymeric Systemsmentioning

confidence: 99%

Section: Flavonoid-loaded Polymeric Systemsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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Polymeric Systems for the Controlled Release of Flavonoids

2023

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“…Naringenin is a flavanone usually present in citrus fruits. This flavanone has different pharmacological and biological properties regarding its antioxidant activity, which is related to anti-inflammatory and anti-tumor action, antimicrobial activity, and also fights the development of atherosclerosis (74,75). According to Smurthi et al (74) naringenin is also present in glycosidic form, as naringin, which is responsible for the bitterness of the fruits.…”

Section: Bioactive Potential Of Mead: Effect Of the Addition Of Diffe...mentioning

confidence: 99%

How Do Different Ingredients and Additives Affect the Production Steps and the Bioactive Potential of Mead?

Simão

Wanderley

Vieira

et al. 2023

Food Technol. Biotechnol. (Online)

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Mead is a fermented alcoholic beverage that is made of honey diluted in water and commonly added with other ingredients. The chemical characteristics of mead are closely related to the ingredients and additives that are used in its preparation, especially the type of honey, the yeast strain, and the pre-fermentation nutrients, as well as herbs, spices and/or fruits. These additives can affect not only the fermentation process, in particular the yeast activity, the formation of metabolites and the fermentation time, but also the bioactive potential of the mead, which is mainly related to its profile of phenolic compounds. Scientific studies have shown that meads added with different plant species contain considerable amounts of different classes of polyphenols, which have important biological activities. Within this context, this review study sought to investigate how different ingredients and additives can affect each of the stages of the preparation of mead, as well as its bioactive potential, in order to understand the effects on its chemical composition, and thus add greater commercial value to this beverage.

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“…Many biosafe and biodegradable materials have been utilized as nanocarriers to prepare the nanodelivery system for NRG, in particular, chitosan [21,22], cyclodextrin [23,24], polylactic acid [25,26], polylactic acid/glycolic acid copolymer [27,28], polycaprolactone [29,30], poly(vinylpyrrolidone) [31], and tocopheryl polyethylene glycol succinate (TPGS) [32,33]. Among them, TPGS has been utilized broadly as a nanocarrier to encapsulate NRG, because of its excellent amphiphilic properties, entrapment efficacy, and biosafety [34,35].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Naringenin Nanoparticles to Improve the Antitussive Effects on Post-Infectious Cough

Dong

Wang

et al. 2022

Molecules

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Naringenin (NRG) is a natural compound with several biological activities; however, its bioavailability is limited owing to poor aqueous solubility. In this study, NRG nanoparticles (NPs) were prepared using the wet media milling method. To obtain NRG NPs with a small particle size and high drug-loading content, the preparation conditions, including stirring time, temperature, stirring speed, and milling media amount, were optimized. The NRG (30 mg) and D-α-tocopherol polyethylene glycol succinate (10 mg) were wet-milled in deionized water (2 mL) with 10 g of zirconia beads via stirring at 50 °C for 2 h at a stirring speed of 300 rpm. As a result, the NRG NPs, with sheet-like morphology and a diameter of approximately 182.2 nm, were successfully prepared. The NRG NPs were stable in the gastrointestinal system and were released effectively after entering the blood circulation. In vivo experiments indicated that the NRG NPs have good antitussive effects. The cough inhibition rate after the administration of the NRG NPs was 66.7%, cough frequency was three times lower, and the potential period was 1.8 times longer than that in the blank model group. In addition, the enzyme biomarkers and histological analysis results revealed that the NRG NPs can effectively regulate the inflammatory and oxidative stress response. In conclusion, the NRG NPs exhibited good oral bioavailability and promoted antitussive and anti-inflammatory effects.

show abstract

A comparative study of optimized naringenin nanoformulations using nano-carriers (PLA/PVA and zein/pectin) for improvement of bioavailability

Cited by 45 publications

References 39 publications

Polymeric Systems for the Controlled Release of Flavonoids

Polymeric Systems for the Controlled Release of Flavonoids

How Do Different Ingredients and Additives Affect the Production Steps and the Bioactive Potential of Mead?

Optimization of Naringenin Nanoparticles to Improve the Antitussive Effects on Post-Infectious Cough

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