A comparative study of pathological changes in informational parameters of rat liver due to experimental exposure during reproductive and senile periods

Abstract

Wistar rats in the reproductive period and the period of pronounced senile changes in norm and pathological conditions were studied. The same informational parameters were also determined for some non-oncological pathologies, for hepatocellular adenoma and for hepatocellular carcinoma at both ages. It is established that in ontogenesis there is an increase in the level of real structural diversity (Н) and coefficient of relative entropy of the system (h). At the same time a decrease of level of organization of system (S) and coefficient of relative organization of system (R) are noted. In the studied periods of ontogenesis, at similar pathologies and pathological processes in liver, in reproductive period of ontogenesis the organ is characterized by fewer devia-tions from the norm and higher level of adaptation and compensative abilities than in the period of pronounced senile changes. Changes in informational condition of liver at hepatitis have the same direction as ontogenetic changes. They lead to an increase in the disorder of the system and a decrease in the level of its integrity, which results in a decrease in the level of adaptive and compensatory resources. In tumors, a decrease in H and h was found with a simultaneous increase in S and R compared to age norms, which are more pronounced in malignant neoplasms. For all the studied pathologies, changes in the information state are more prominent in the liver of rats in the period of pronounced senile changes.