A comparative study of synbiotic as an add-on therapy to standard treatment in patients with aggressive periodontitis

Abstract

Context:The role of synbiotic in the management of aggressive periodontitis (AP) is not well established.Aim:We designed this study to evaluate the efficacy and safety of synbiotic as an add-on therapy in the management of AP.Settings and Design:This was a randomized, double-blind, placebo-controlled study.Materials and Methods:Sixty patients with AP were randomized to two groups of 30 each. Study group received standard treatment, i.e., scaling and root planing along with doxycycline 100 mg twice daily for the 1st day (loading dose) followed by 100 mg once daily for 1 week and synbiotic lozenge twice daily for 8 weeks, whereas control group received standard treatment for 1 week and placebo lozenge for 8 weeks. Clinical parameters were recorded at baseline, 4th, 8th, and 12th weeks.Statistical Analysis Used:Pearson's Chi-square test and one-way analysis of variance were used to analyze distribution of sex and age, respectively. Differences within the groups were analyzed by Student's paired t-test. Pearson's Chi-square test was applied to measure gingival bleeding index.Results:On comparison at 12 weeks, there was a statistically significant reduction (P < 0.01) in probing depth, clinical attachment loss, oral hygiene index, and bleeding on probing in study group. No Adverse drug reactions were noted.Conclusion:Co-administration of synbiotic lozenge along with standard therapy is highly efficacious in improving periodontal health in patients with AP.

Probiotics in Oral Health and Disease: A Systematic Review

“…Murugesan et al [55] evaluated the efficacy of co-administration of doxycycline and synbiotic tablet (consisting of prebiotic Streptococcus faecalis T-110 JPC and probiotics Clostridium butyricum TO-A, Bacillus mesentericus TO-A and L. sporogenes) as adjuvant to SRP in patients with periodontitis. Four weeks after the end of the intervention, a significant reduction of PD, CAL and BOP was observed in the test group indicating that this prebioticprobiotic mixture can be a complement to the mechanical removal and doxycycline to improve clinical parameters, reduce bacterial load and repopulate the treated niche.…”

Aggressive Periodontitis Etiology, Pathophysiology, and Treatment: A Recent Review

“…Synbiotics have antiinflammatory and antimicrobial properties which could have protected against destruction of periodontal tissue and loss of alveolar bone. 59…”