A comparative study of synthetic carnosine analogs as antioxidants

Boldyrev, Alexander A.; Дупин, А. М.; Batrukova, M A; Bavykina, N.I.; Коршунова, Г. А.; Shvachkin, Yu. P.

doi:10.1016/0305-0491(89)90339-8

Cited by 19 publications

(11 citation statements)

References 2 publications

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“…Triangles, squares, and circles indicate WT, pBIT, and pC19T, respectively. Results are shown as the mean ± SD of three strains: pBI-1, pBI-2, and pBI-3 for pBIT; pC19T-11, pC19T-13, and pC19T-14 for pC19T Each lane contains 10 lg of protein dine), which is an antioxidative dipeptide in mammals, showed a 100-fold higher IC 50 (4.5 mg ml )1 ) than CuCOR19 in a similar assay system (Boldyrev et al 1989). This means that more-complicated mechanisms than histidine's effects are behind the antioxidative activity of CuCOR19.…”

Section: Discussionmentioning

confidence: 98%

Enhancement of cold tolerance and inhibition of lipid peroxidation by citrus dehydrin in transgenic tobacco

Hara

Terashima

Fukaya

et al. 2003

Planta

331

153

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Section: Discussionmentioning

confidence: 98%

Enhancement of cold tolerance and inhibition of lipid peroxidation by citrus dehydrin in transgenic tobacco

Hara

Terashima

Fukaya

et al. 2003

Planta

331

153

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“…Acute pre-exercise administration of the antioxidant N-acetyl-cysteine has been shown to improve exercise performance in humans [24]. Also carnosine and anserine have been widely investigated and consensually accepted as powerful antioxidants [2,25,26], but it is unclear whether they can be involved in protection against oxidative stress and fatigue during exercise in vivo. Chronic β-alanine supplementation has been shown to reduce a marker of lipid peroxidation (TBARS) during downhill running in rats [27], but data in humans on chronic supplementation of β-alanine [28] or acute supplementation of carnosine [9] did not show reduction in oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Ergogenic effect of pre-exercise chicken broth ingestion on a high-intensity cycling time-trial

Barbaresi

Blancquaert

Николовски

et al. 2021

Journal of the International Society of Sports Nutrition

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Background chicken meat extract is a popular functional food in Asia. It is rich in the bioactive compounds carnosine and anserine, two histidine-containing dipeptides (HCD). Studies suggest that acute pre-exercise ingestion of chicken extracts has important applications towards exercise performance and fatigue control, but the evidence is equivocal. This study aimed to evaluate the ergogenic potential of the pre-exercise ingestion of a homemade chicken broth (CB) vs a placebo soup on a short-lasting, high-intensity cycling exercise. Methods fourteen men participated in this double-blind, placebo-controlled, crossover intervention study. Subjects ingested either CB, thereby receiving 46.4 mg/kg body weight of HCD, or a placebo soup (similar in taste without HCD) 40 min before an 8 min cycling time trial (TT) was performed. Venous blood samples were collected at arrival (fasted), before exercise and at 5 min recovery. Plasma HCD were measured with UPLC-MS/MS and glutathione (in red blood cells) was measured through HPLC. Capillary blood samples were collected at different timepoints before and after exercise. Results a significant improvement (p = 0.033; 5.2%) of the 8 min TT mean power was observed after CB supplementation compared to placebo. Post-exercise plasma carnosine (p < 0.05) and anserine (p < 0.001) was significantly increased after CB supplementation and not following placebo. No significant effect of CB supplementation was observed either on blood glutathione levels, nor on capillary blood analysis. Conclusions oral CB supplementation improved the 8 min TT performance albeit it did not affect the acid-base balance or oxidative status parameters. Further research should unravel the potential role and mechanisms of HCD, present in CB, in this ergogenic approach.

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“…The antioxidant activity of carnosine was initially studied by Boldyrev et al since the 1980s (65)(66)(67). Later on, several studies were reported, showing a direct and indirect antioxidant activity of carnosine, as demonstrated in several in vitro studies (see below).…”

Section: Antioxidant Activitymentioning

confidence: 99%

Physiology and Pathophysiology of Carnosine

Boldyrev

Aldini

Derave

2013

Physiological Reviews

902

1,023

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Carnosine (β-alanyl-l-histidine) was discovered in 1900 as an abundant non-protein nitrogen-containing compound of meat. The dipeptide is not only found in skeletal muscle, but also in other excitable tissues. Most animals, except humans, also possess a methylated variant of carnosine, either anserine or ophidine/balenine, collectively called the histidine-containing dipeptides. This review aims to decipher the physiological roles of carnosine, based on its biochemical properties. The latter include pH-buffering, metal-ion chelation, and antioxidant capacity as well as the capacity to protect against formation of advanced glycation and lipoxidation end-products. For these reasons, the therapeutic potential of carnosine supplementation has been tested in numerous diseases in which ischemic or oxidative stress are involved. For several pathologies, such as diabetes and its complications, ocular disease, aging, and neurological disorders, promising preclinical and clinical results have been obtained. Also the pathophysiological relevance of serum carnosinase, the enzyme actively degrading carnosine into l-histidine and β-alanine, is discussed. The carnosine system has evolved as a pluripotent solution to a number of homeostatic challenges. l-Histidine, and more specifically its imidazole moiety, appears to be the prime bioactive component, whereas β-alanine is mainly regulating the synthesis of the dipeptide. This paper summarizes a century of scientific exploration on the (patho)physiological role of carnosine and related compounds. However, far more experiments in the fields of physiology and related disciplines (biology, pharmacology, genetics, molecular biology, etc.) are required to gain a full understanding of the function and applications of this intriguing molecule.

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A comparative study of synthetic carnosine analogs as antioxidants

Cited by 19 publications

References 2 publications

Enhancement of cold tolerance and inhibition of lipid peroxidation by citrus dehydrin in transgenic tobacco

Enhancement of cold tolerance and inhibition of lipid peroxidation by citrus dehydrin in transgenic tobacco

Ergogenic effect of pre-exercise chicken broth ingestion on a high-intensity cycling time-trial

Physiology and Pathophysiology of Carnosine

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