A comparative study of the clinical manifestations of systemic lupus erythematosus in Caucasians in Rochester, Minnesota, and Chinese in Singapore, from 1980 to 1992

Thumboo, Julian; Uramoto, Kristine; O’Fallon, W. Michael; Fong, Kok Yong; Ml, Boey; Feng, Po-Hao; Thio, S T; Gabriel, Sherine E.; Chng, Hiok Hee; Howe, Hwee Siew; Koh, Ee Tzun; Koh, W H; Leong, Keng Hong; Leong, Khai Pang

doi:10.1002/1529-0131(200112)45:6<494::aid-art374>3.0.co;2-m

Cited by 63 publications

(54 citation statements)

References 22 publications

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“…thrombocytopenia and leukopenia) and serositis were much less common in our patients compared with other populations. Similarly, Chinese SLE patients in Singapore were found to be less likely to have serositis and hematologic disorders when compared with white SLE patients [15]. Among the clinical syndromes, nephrotic syndrome was the most common, whereas AIHA recorded the longest interval preceding SLE diagnosis, at an average of 20.3 months.…”

Section: Discussionmentioning

confidence: 99%

Clinical manifestations and clinical syndromes of Filipino patients with systemic lupus erythematosus

Villamin

Navarra

2008

Mod Rheumatol

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The aim of this study was to describe the presenting clinical manifestations and syndromes of Filipino patients on diagnosis of systemic lupus erythematosus (SLE). We performed a retrospective review of medical records of Filipino SLE patients included in the lupus database of the University of Santo Tomas (UST) in Manila, Philippines. All patients fulfilled the American College of Rheumatology criteria for SLE. The following data were recorded: (1) demographic profile, (2) clinical manifestations on SLE diagnosis, and (3) clinical syndromes prior to and during fulfillment of diagnostic criteria for SLE and disease interval from diagnosis of a clinical syndrome to SLE diagnosis. Clinical data of 1,070 patients entered into the UST lupus database as of October 2005 were analyzed. The average age at SLE diagnosis was 28.5 +/- 11.5 (range 5-71) years, with 1,025 female and 45 male subjects. The most common presenting manifestation was arthritis (68%), followed by malar rash (49%), renal involvement (47%), photosensitivity (33%), and oral ulcers (33%). The following clinical syndromes were recorded prior to or during SLE diagnosis: nephrotic syndrome (30%), undifferentiated connective tissue disease (UCTD) (22%), autoimmune hemolytic anemia (AIHA) (6%), and idiopathic thrombocytopenic purpura (ITP) (6%). Among these, AIHA preceded the diagnosis of SLE at the longest interval (20.3 +/- 30.6, range 1-194 months). In this large database of Filipino patients with SLE, the most common presenting manifestation was arthritis, with renal involvement occurring in almost 50%. Among the clinical syndromes, nephrotic syndrome was the most common, whereas AIHA recorded the longest interval preceding SLE diagnosis, at an average of 20.3 months. Our findings are similar to data from other countries and emphasize the broad range of manifestations of SLE. The findings also reinforce the need to establish and maintain SLE databases to enhance awareness, early diagnosis, and more efficient management of the disease.

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Section: Discussionmentioning

confidence: 99%

Clinical manifestations and clinical syndromes of Filipino patients with systemic lupus erythematosus

Villamin

Navarra

2008

Mod Rheumatol

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“…Although ethnic and racial differences in the clinical expression of SLE have been researched actively [19][20][21][22], NPSLE has not been the primary focus of research attention. The few studies documenting nervous system involvement have not used the standardized criteria for NPSLE.…”

Section: Ethnicity and Age Of Systemic Lupus Erythematosus Onsetmentioning

confidence: 91%

“…Anti-P antibodies are specific to SLE. Prevalence varies across ethnic groups, being increased in Chinese patients in Singapore compared with white patients in the United States, in line with the higher rate of psychiatric manifestations, especially psychosis, observed in the Chinese patients [19].…”

Section: Psychiatric Disordersmentioning

confidence: 99%

Neuropsychiatric involvement in systemic lupus erythematosus

Hermosillo-Romo¹,

Brey

2002

Curr Rheumatol Rep

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The correct diagnosis of central and peripheral nervous system manifestations in patients with systemic lupus erythematosus (SLE) can be challenging because of many SLE-related and non-SLE-related processes that can be present in a patient. The American College of Rheumatology (ACR) has published case definitions for 19 neuropsychiatric SLE (NPSLE) syndromes, with careful attention to important exclusion criteria. These criteria were developed for research purposes but can be helpful to clinicians with a patient who has nervous system dysfunction. This report reviews the data regarding the application of the ACR NPSLE criteria and the influence of ethnicity and disease duration on the development of NPSLE syndromes. Cognitive dysfunction and psychiatric disorders are the two most common manifestations. The work-up and treatment of nervous system syndromes are also discussed.

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“…Well characterised differences between ethnic groups regarding clinical manifestations of some other major inflammatory conditions, such as systemic lupus erythematosus [9], have been described, but there is little data about inter-ethnic differences in AS patients. Characterising differences between ethnic groups is an important process, potentially guiding research into determinants of disease manifestations and severity and being of obvious relevance for the clinical management in the different ethnic groups concerned.…”

Section: Introductionmentioning

confidence: 99%

Spectrum of ankylosing spondylitis in Portugal. Development of BASDAI, BASFI, BASMI and mSASSS reference centile charts

et al. 2011

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The availability of population-specific normative data regarding disease severity measures is essential for patient assessment. The goals of the current study were to characterize the pattern of ankylosing spondylitis (AS) in Portuguese patients and to develop reference centile charts for BASDAI, BASFI, BASMI and mSASSS, the most widely used assessment tools in AS. AS cases were recruited from hospital outpatient clinics, with AS defined according to the modified New York criteria. Demographic and clinical data were recorded. All radiographs were evaluated by two independent experienced readers. Centile charts for BASDAI, BASFI, BASMI and mSASSS were constructed for both genders, using generalized linear models and regression models with duration of disease as independent variable. A total of 369 patients (62.3% male, mean±(SD) age 45.4±13.2 years, mean±(SD) disease duration 11.4 ± 10.5 years, 70.7% B27-positive) were included. Family history of AS in a first-degree relative was reported in 17.6% of the cases. Regarding clinical disease pattern, at the time of assessment 42.3% had axial disease, 2.4% peripheral disease, 40.9% mixed disease and 7.1% isolated enthesopatic disease. Anterior uveitis Matthew A Brown and Jaime C Branco equally contributed to this study.

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A comparative study of the clinical manifestations of systemic lupus erythematosus in Caucasians in Rochester, Minnesota, and Chinese in Singapore, from 1980 to 1992

Cited by 63 publications

References 22 publications

Clinical manifestations and clinical syndromes of Filipino patients with systemic lupus erythematosus

Clinical manifestations and clinical syndromes of Filipino patients with systemic lupus erythematosus

Neuropsychiatric involvement in systemic lupus erythematosus

Spectrum of ankylosing spondylitis in Portugal. Development of BASDAI, BASFI, BASMI and mSASSS reference centile charts

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