A Comparative Study of the Activity of Some Cytostatic Agents on a Biological Test ‘in vivo’

Carrara, Paolo; Eridani, S

doi:10.1159/000205444

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Effect On the Maturation Activity Of Subcellular Fractions O1

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1961

1969

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Cited by 3 publications

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“…The in vitro test, according to Bussi (2) and Astaldi et al (1) on blood forming cells of the chick embryo has been fully described in previous papers (4)(5)(6).…”

Section: Effect On the Maturation Activity Of Subcellular Fractions Omentioning

confidence: 99%

Cytological Effects of an Antagonist of Vitamin B<sub>12</sub>

et al. 1961

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“…The in vitro test, according to Bussi (2) and Astaldi et al (1) on blood forming cells of the chick embryo has been fully described in previous papers (4)(5)(6).…”

Section: Effect On the Maturation Activity Of Subcellular Fractions Omentioning

confidence: 99%

Cytological Effects of an Antagonist of Vitamin B<sub>12</sub>

et al. 1961

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Influence of antiblastic agents applied either in vivo or in vitro on human lymphocyte transformation in cell culture

Astaldi

Eridani

Ponti

et al. 1969

Blut

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Biologic Effects of Recent Antimitotic Compounds:A comparative evaluation

Eridani

Tiso

Ponti

et al. 1967

Acta genet. med. gemellol.

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SummaryAn evaluation of the antimitotic activity of a group of antitumoral agents was performed. Their action was first assayed on chick embryo blood forming tissue, determining its survival, mitotic index and mitotic differential count: the statistically most active compounds were demecolcin, vinblastine and cyclophosphamide.The same compounds were also tested on the in vitro blastic transformation of human leukocytes and their incorporation of tritiated DNA and RNA precursors.The most active compounds in this assay was 5 fluorouracil; a lesser degree of inhibition was caused by vinblastine, cyclophosphamide and mechloretamine.The effect of a single massive dose of the same compounds in vivo was also studied determining the in vitro activity of leukocytes of such patients, removed 48 hrs after the administration.Preliminary results show that such leukocytes lose in variable degree their phyto-responsiveness in vitro.

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A Comparative Study of the Activity of Some Cytostatic Agents on a Biological Test ‘in vivo’

Cited by 3 publications

References 1 publication

Cytological Effects of an Antagonist of Vitamin B<sub>12</sub>

Cytological Effects of an Antagonist of Vitamin B<sub>12</sub>

Influence of antiblastic agents applied either in vivo or in vitro on human lymphocyte transformation in cell culture

Biologic Effects of Recent Antimitotic Compounds:A comparative evaluation

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