A comparative study of the areas of osteochondral defects produced in femoral condyles of rabbits treated with sugar cane biopolymer gel

Albuquerque, Paulo Cezar Vidal Carneiro de; Aguiar, José Lamartine de Andrade; Filho, Nicodemos Teles de Pontes; Mello, Roberto José Vieira de; Olbertz, Clarissa Miranda Carneiro de Albuquerque; Albuquerque, Paula Eduarda Miranda Carneiro de; Paz, Silvânia Tavares; Santos, Alessandro Henrique da Silva; Maia, Carina Scanoni

doi:10.1590/s0102-865020150110000008

Cited by 4 publications

(4 citation statements)

References 33 publications

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“…In addition to inflammation, it can be observed constant bone degeneration and osteophyte formation, seen in the radiographic images shown in this experiment. This model has served as the basis for experimental treatment of osteoarthritis in various ways [24][25][26] .…”

Section: Microscopic Analysismentioning

confidence: 99%

“…The Roto-rod, although initially designed for forced ambulation on gait in lesions of the cerebellum 15 , is also used in the grading of joint function in experimental neurological compressions 27 , and joint changes in experimental arthritis of the knees 16,25 . This study showed that the greatest difference occurred in 7 and 14 days after induction.…”

Section: Control Group (Cg)mentioning

confidence: 99%

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Osteoarthritis model induced by intra-articular monosodium iodoacetate in rats knee

et al. 2016

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PURPOSE:To evaluate the usefulness of a knee osteoarthritis model through functional, radiological and microscopic changes of the synovial membrane. METHODS:Forty eight rats were divided randomly into two groups. The first received 0.9% saline in the joint and corresponded to the control group. The second was submitted to experimental osteoarthritis of the right knee induced by monosodium iodoacetate and corresponded to the osteoarthritis group. All animals were subjected to comparative tests of forced ambulation and joint movements, inability to articulate and tactile allodynia on day 1 post-experiment by forced ambulation (Roto-rod test), joint assessment of disability (weight bearing test) and assessment of tactile allodynia (Von Frey test). After inflammatory induction they were divided into four subgroups corresponding to the scheduled death in 7, 14, 21 and 28 days when they were submitted to radiographic examination of the knee, arthrotomy and collection of the synovial membrane. RESULTS:The osteoarthritis group showed significant differences compared to control group on days 7 and 14 in Roto-rod, in weight bearing and Von Frey tests in all days, and in radiological evaluation. Microscopic examination of the synovial membrane showed abnormalities of inflammatory character at all stages. CONCLUSION:The osteoarthritis induced by intra-articular monosodium iodoacetate in rats knee is a good model to be used in related research, because it provides mensurable changes on joint movements, tactile allodynia, progressive radiological degeneration and microscopic inflammation of the synovial membrane, that represent markers for osteoarthritis evaluation

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Section: Microscopic Analysismentioning

confidence: 99%

Section: Control Group (Cg)mentioning

confidence: 99%

Osteoarthritis model induced by intra-articular monosodium iodoacetate in rats knee

et al. 2016

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“…A study carried out addressing the cytotoxicity, genotoxicity and antigenotoxicity of BC when testing it in vitro and in vivo in rats, demonstrated that they are neither cytotoxic nor genotoxic [14,20], other studies also addressed the theme and proved BC biocompatibility and atoxicity [21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Bacterial cellulose an effective material in the treatment of chronic venous ulcers of the lower limbs

Silva

Albuquerque

Pinto

et al. 2021

J Mater Sci: Mater Med

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Chronic venous ulcers (CVU) of the lower limbs (LL) are common and cause psychological changes and significant social impact, as they make the patient susceptible to pain, absence from work and social bonds. Some materials are suggested as dressings for the treatment of CVU, but they are expensive and are generally not available for use in public health services. To evaluate the efficacy of the treatment for lower limbs (LL) chronic venous ulcer (CVU) using bacterial cellulose (BC), gel and multi-perforated film associated. A randomized controlled clinical-intervention study was performed among participants with LL CVU, divided into two groups: experimental (EG), treated with BC wound dressing and control (CG), treated with a cellulose acetate mesh impregnated with essential fatty acids (Rayon®). The participants were followed for 180 days, evaluated according to the MEASURE methodology. Thirty-nine patients were treated, 20 from the EG and 19 from the CG. In both groups, the wound area decreased significantly (p < 0.001), the healing rate was similar to the CG. The mean number of dressing changes in the SG was 18.33 ± 11.78, while in the CG it was 55.24 ± 25.81, p < 0.001. The healing dressing of bacterial cellulose, gel and associated film, when stimulating the epithelization of the lesions, showed a significant reduction in the initial area, with a percentage of cure similar to the Rayon® coverage. In addition to requiring less direct manipulation of ulcers.

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“…Furthermore, additional surgical is required to remove the non-degradable nerve conduits. For this reason, research in the last decade has intensified, in an attempt to analyze biocompatible materials and capable of bio-absorption for use as guide tubes for bridging to axonal growth (Albuquerque et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Sugarcane Biopolymer as a Guide Tube in the Regeneration of Peripheral Nerves in Rats

et al. 2019

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Peripheral nerve regeneration is a serious clinical problem. The goal of this work was to evaluate comparatively a biopolymer tube of sugarcane with an expanded polyethylene tube as a tube guide in peripheral nerve regeneration. Fourteen male albino Wistar rats were used, separated into three different groups: control (CG), lesion + polyethylene tube (PG) and lesion + sugarcane biopolymer (SBG). At 60 days old, animals from the PG and SBG underwent surgery for tubulization of the sciatic nerve, and 60 days after the injury they were sacrificed for collection of the nerve. In the analysis of the number of nerve fibers, a smaller number was seen in the PG and SBG groups compared to the CG, no difference was seen between the PG and SBG groups (p<0.05). With regard to the number of blood vessels, the SBG group had a larger number than the CG and PG groups (p<0.05). The SBG also presented increase on axonal diameter and G -ratio compared to PG (p<0.05). Taken together these data revealed that biopolymer tube favors a suitable environment for peripheral nerve regeneration.

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A comparative study of the areas of osteochondral defects produced in femoral condyles of rabbits treated with sugar cane biopolymer gel

Cited by 4 publications

References 33 publications

Osteoarthritis model induced by intra-articular monosodium iodoacetate in rats knee

Osteoarthritis model induced by intra-articular monosodium iodoacetate in rats knee

Bacterial cellulose an effective material in the treatment of chronic venous ulcers of the lower limbs

Sugarcane Biopolymer as a Guide Tube in the Regeneration of Peripheral Nerves in Rats

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