A Comparative Study of the Specificity of Fucoidanases of Marine Microorganisms and Invertebrates

Кусайкин, М. И.; Chizhov, Alexander O.; Alekseeva, S. A.; Bakunina, I. Yu.; Nedashkovskaya, Olga I.; Sova, V. V.; Zvyagintseva, T. N.; Elyakov, G. B.

doi:10.1023/b:dobi.0000033525.32259.15

Cited by 9 publications

(4 citation statements)

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“…Enzymatic hydrolysis of fucoidans is the most promising approach leading to oligosaccharides. Marine invertebrates and marine bacteria are regarded as possible sources of the corresponding enzymes [56]. For example, a fucoidan-degrading activity was found in the digestive glands of the marine mollusk Pecten maximus [57].…”

Section: Structural Analysis Of Fucoidansmentioning

confidence: 99%

“…Bacterial enzymes seem to be more useful in the structural analysis of fucoidans. Many marine bacteria have fucoidanase activities [56], as, for example, Pseudoalteromonas citrea [61]. Usually application of a bacterial enzyme for partial cleavage of a given fucoidan should start with the search of an appropriate bacterial strain, followed by cultivation of the bacterium using the selected fucoidan as a substrate.…”

Section: Structural Analysis Of Fucoidansmentioning

confidence: 99%

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Structural Analysis of Fucoidans

Bilan

Усов

2008

Natural Product Communications

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Sulfated polysaccharides of brown algae ("fucoidans") constitute a wide variety of biopolymers from simple sulfated fucans up to complex heteropolysaccharides composed of several neutral monosaccharides, uronic acid and sulfate. The increased interest in this class of polysaccharides is explained by their high and versatile biological activities, and hence, by their possible use in new drug design. Structural analysis of several fucoidans demonstrates that their biological properties are determined not only by charge density, but also by fine chemical structure, although distinct correlations between structure and biological activity cannot be formulated at present. The aim of this review is to describe the methods of structural analysis currently used in fucoidan chemistry, and to discuss some new information on the structures of fucoidans presented in recent publications.

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Section: Structural Analysis Of Fucoidansmentioning

confidence: 99%

Section: Structural Analysis Of Fucoidansmentioning

confidence: 99%

Structural Analysis of Fucoidans

Bilan

Усов

2008

Natural Product Communications

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“…Fucoidan isolated from L. cichorioides kelp is (1→3)-α-L-fucan (Fuc, 100%) sulfated by C-2 and by C-4, the ratio of SO 4 2-:Fuc being 0.8:1.0. The molecular weight distribution peaks of polysaccharides derived from F. evanescens and L. cichorioides correspond to 30 and 50 kDa, respectively [3,13].…”

Section: Resultsmentioning

confidence: 99%

Pharmacodynamic parameters of anticoagulants based on sulfated polysaccharides from marine algae

et al. 2006

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Fucoidans isolated from Fucus evanescens and Laminaria cichorioides kelp can inhibit thrombin and factor Xa of the blood coagulation system. In rats, intravenous injection of fucoidans dose-dependently increased anticoagulant activity of the plasma. Fucoidans can form complexes with protamine sulfate. The observed quantitative differences in the action of fucoidans can result from different sulfation degree and the presence of various types of glycoside bonds in polysaccharide molecules.

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“…In this case, marine invertebrates and marine bacteria are the sources of enzymes-fucoidanases [142]. So, as affected of alkaline fucoidanаse from Littorina kurila yield of LMW sulfated products from F. evanescens which was three times higher compare with action of acid fucoidanase was observed [143,144]. By means of enzymatic hydrolysis of fucoidan from brown alga F. evanescens using of fucoidanase from marine bacteria Formosa algae the product with Mm ~9 kDa was obtained [141,145].…”

Section: Oligosaccharidesmentioning

confidence: 99%

The Sulfated Polysaccharides of Brown Algae and Products of Their Enzymatic Transformation as Potential Vaccine Adjuvants

Кузнецова

Persiyanova²,

Ermakova

et al. 2018

Natural Product Communications

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The review is devoted to critical analysis of literature data, deal with effects and mechanisms of action of sulfated polysaccharides (PSs)-fucoidans from brown algae and products of their enzymatic transformation as potential adjuvants for enhancement of anti-infective and antitumor immune response. Numerous experimental data indicate that sulfated PSs demonstrate properties of vaccine adjuvants. Application perspectiveness of fucoidans as vaccine adjuvants is defined by their high biocompatibility, low-toxicity, safety and good tolerance by macroorganism, and also mechanisms of their immunomodulatory action. In particular, fucoidans are agonists of receptors of innate immunity and strong inducers of cellular and humoral immune response. At presenting the data of structural-functional interrelations, attention focused to the defining role of degree of sulfation, uronic acids and polyphenols contents, and also molecular mass in actions of fucoidans to innate and adaptive immunity cells. Insufficiency of literary data on studying of correlation of structure-physicochemical characteristics with adjuvanticities of the sulfated PSs, and also the problem of standardization of their active fractions are noted. Special attention is paid to the analysis of immunomodulatory and adjuvant activity of fucoidan oligosaccharides. Presented here results of experimental trial indicate that, despite the difficulties due to preparation of highly purified structurally characterized fractions and complex structure of fucoidans, these substances can be used as safe and effective adjuvants in vaccines against various pathogens including viruses, and also in antitumor vaccines.

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A Comparative Study of the Specificity of Fucoidanases of Marine Microorganisms and Invertebrates

Cited by 9 publications

References 4 publications

Structural Analysis of Fucoidans

Structural Analysis of Fucoidans

Pharmacodynamic parameters of anticoagulants based on sulfated polysaccharides from marine algae

The Sulfated Polysaccharides of Brown Algae and Products of Their Enzymatic Transformation as Potential Vaccine Adjuvants

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