A comparative study of the effectiveness of sinus bone grafting with recombinant human bone morphogenetic protein 2–coated tricalcium phosphate and platelet-rich fibrin–mixed tricalcium phosphate in rabbits

Kim, Bok-Joo; Kwon, Taek-Kyun; Baek, Hyun-Su; Hwang, Deok‐Sang; Kim, Chul-Hun; Chung, Il‐Kwun; Jeong, Jin–Sook; Shin, Sang‐Hun

doi:10.1016/j.tripleo.2011.04.029

Cited by 38 publications

(33 citation statements)

References 40 publications

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“…Zhang et al found no an advantage or disadvantage of the applying of PRF in combination with deproteinized bovine bone mineral (Bio‐Oss) for sinus‐floor augmentation. In contrast, Kim et al filled round‐shaped defects in the maxillary anterior sinus walls of rabbits with three different graft materials (TCP only, PRF‐mixed TCP, or rhBMP‐2‐coated TCP), and reported that PRF‐mixed TCP showed more rapid bone healing than the rhBMP‐2‐coated TCP or the TCP‐only control.…”

Section: Introductionsupporting

confidence: 89%

Histologic and histomorphometric assessment of sinus‐floor augmentation with beta‐tricalcium phosphate alone or in combination with pure‐platelet‐rich plasma or platelet‐rich fibrin: A randomized clinical trial

Kılıç

Güngörmüş

Parlak

2017

Clin Implant Dent Rel Res

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Section: Introductionsupporting

confidence: 89%

Histologic and histomorphometric assessment of sinus‐floor augmentation with beta‐tricalcium phosphate alone or in combination with pure‐platelet‐rich plasma or platelet‐rich fibrin: A randomized clinical trial

Kılıç

Güngörmüş

Parlak

2017

Clin Implant Dent Rel Res

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“…Kim et al observed rapid bone formation, remodelling, and calcification in rabbits in the second week with combination of PRF with β-TCP than the β-TCP alone 13. In the present case, it was observed that at 3, 6, 9 and 12 months follow-up after the surgical treatment of large chronic periapical lesion, PRF combined with β-TCP resulted in significant clinical and radiographic bone regeneration.…”

Section: Discussionsupporting

confidence: 57%

Clinical effectiveness of combining platelet rich fibrin with alloplastic bone substitute for the management of combined endodontic periodontal lesion

Goyal

2014

Restor Dent Endod

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The term "endo-perio" lesion has been proposed to describe the destructive lesion resulting from inflammatory products found in varying degrees in both the periodontium and the pulpal tissues. In most of the cases, clinical symptoms disappear following successful endodontic therapy. However failure after conventional root canal treatment calls for surgical intervention. A 35 year old male patient with endo-perio lesion in right maxillary lateral incisor was treated with platelet rich fibrin (PRF) and alloplastic bone substitute after conventional endodontic therapy. At the end of 6 months there was gain in clinical attachment, increased radiographic bone fill and reduction in probing depth which was maintained till 18 month follow-up. Present case report aims to evaluate the efficacy of PRF and alloplastic bone substitute in the management of intrabony defect associated with endo-perio lesion in maxillary lateral incisor because the healing potential of PRF and bone graft has not been widely studied in endodontics. The use of PRF allows the clinician to optimize tissue remodelling, wound healing and angiogenesis by the local delivery of growth factors and proteins. The novel technique described here enables the clinician to be benefited from the full regenerative capacity of this autologous biologic material.

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“…Kim et al 34 used TCP, PRF+TCP, and recombinant human bone morphogenic protein 2 (rhBMP-2)–coated TCP in the augmentation of the maxillary sinus in rabbits. The animals were killed at 3 days and at 1, 2, 4, 6, and 8 weeks.…”

Section: Discussionmentioning

confidence: 99%

The Use of Platelet-Rich Fibrin in Combination With Biphasic Calcium Phosphate in the Treatment of Bone Defects: A Histologic and Histomorphometric Study

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Tekkeşın

et al. 2013

Current Therapeutic Research

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BackgroundPlatelet-rich fibrin (PRF) is a leukocyte and platelet concentrate containing many growth factors. Its potential for hard tissue augmentation as a sole grafting material or in combination with other grafting materials has been investigated in many studies.ObjectiveThe aim of this histologic study was to evaluate the efficacy of PRF mixed with biphasic calcium phosphate (BCP) on bone regeneration in surgically created bone defects.MethodsDefects 5 mm in diameter were created in both tibias of 6 sheep. The defects were left empty or grafted with BCP, PRF, or BCP+PRF. Animals were killed at 10, 20, and 40 days. The specimens underwent histologic and histomorphometric analysis.ResultsNone of the groups displayed any signs of necrosis. Inflammation was observed in all groups at 10 days; 2 specimens of PRF+BCP and all empty defects showed inflammatory cell infiltration at 20 days. During the 40-day evaluation period, the PRF+BCP group showed the highest ratios of new bone. The other 3 groups showed statistically similar results. In the BCP and PRF+BCP groups, the residual graft ratios were decreased at consecutive time intervals. The difference between the 2 groups was not statistically significant during follow-up.ConclusionsThe current study revealed a histomorphometric increase in bone formation with the addition of PRF to BCP in surgically created defects in sheep tibia.

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A comparative study of the effectiveness of sinus bone grafting with recombinant human bone morphogenetic protein 2–coated tricalcium phosphate and platelet-rich fibrin–mixed tricalcium phosphate in rabbits

Cited by 38 publications

References 40 publications

Histologic and histomorphometric assessment of sinus‐floor augmentation with beta‐tricalcium phosphate alone or in combination with pure‐platelet‐rich plasma or platelet‐rich fibrin: A randomized clinical trial

Histologic and histomorphometric assessment of sinus‐floor augmentation with beta‐tricalcium phosphate alone or in combination with pure‐platelet‐rich plasma or platelet‐rich fibrin: A randomized clinical trial

Clinical effectiveness of combining platelet rich fibrin with alloplastic bone substitute for the management of combined endodontic periodontal lesion

The Use of Platelet-Rich Fibrin in Combination With Biphasic Calcium Phosphate in the Treatment of Bone Defects: A Histologic and Histomorphometric Study

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