A comparative study of the bone metabolic response to dried plum supplementation and PTH treatment in adult, osteopenic ovariectomized rat

Smith, Brenda J.; Bu, So Young; Wang, Yan; Rendina, Elizabeth; Lim, Yin F.; Marlow, Denver; Clarke, Stephen; Cullen, D. M.; Lucas, Edralin A.

doi:10.1016/j.bone.2013.10.005

Cited by 53 publications

(45 citation statements)

References 33 publications

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“…Specifically, OVX induced significantly increased MAR which caused further deterioration. However, minodronic acid and dried plum suppressed OVX-induced increases in bone turnover at the tissue level, thereby improving the deterioration of bone quality under osteoporotic disease conditions6566. In our study, we observed that SAL possessed the similar results in vivo .…”

Section: Discussionsupporting

confidence: 66%

Protective effect of salidroside against bone loss via hypoxia-inducible factor-1α pathway-induced angiogenesis

Li¹,

Jin

et al. 2016

Sci Rep

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Hypoxia-inducible factor (HIF)-1α plays a critical role in coupling angiogenesis with osteogenesis during bone development and regeneration. Salidroside (SAL) has shown anti-hypoxic effects in vitro and in vivo. However, the possible roles of SAL in the prevention of hypoxia-induced osteoporosis have remained unknown. Two osteoblast cell lines, MG-63 and ROB, were employed to evaluate the effects of SAL on cell viability, apoptosis, differentiation and mineralization in vitro. Rats subjected to ovariectomy-induced bone loss were treated with SAL in vivo. Our results showed that pre-treatment with SAL markedly attenuated the hypoxia-induced reductions in cell viability, apoptosis, differentiation and mineralization. SAL down-regulated HIF-1α expression and inhibited its translocation; however, SAL increased its transcriptional activity and, consequently, up-regulated vascular endothelial growth factor (VEGF). In vivo studies further demonstrated that SAL caused decreases in the mineral, alkaline phosphatase (ALP), and BGP concentrations in the blood of ovariectomized (OVX) rats. Moreover, SAL improved the trabecular bone microarchitecture and increased bone mineral density in the distal femur. Additionally, SAL administration partially ameliorated this hypoxia via the HIF-1α-VEGF signalling pathway. Our results indicate that SAL prevents bone loss by enhancing angiogenesis and osteogenesis and that these effects are associated with the activation of HIF-1α signalling.

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Section: Discussionsupporting

confidence: 66%

Protective effect of salidroside against bone loss via hypoxia-inducible factor-1α pathway-induced angiogenesis

Li¹,

Jin

et al. 2016

Sci Rep

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“…The results from this in vitro experiment by Bu et al (2008) has also been confirmed in animal studies (Deyhim et al, 2005;Franklin et al, 2006;Bu et al, 2007;Smith et al, 2014a). Among these, the study by Smith et al (2014a) is slightly different in that unlike the other studies that studied longer term effects of dried plum on systemic biochemical markers of bone metabolism and alteration in gene expression as the main outcome measure, their main objective was to understand the mechanism of action by which dried plum altered bone metabolism.…”

Section: Bone Healthsupporting

confidence: 57%

“…PRISMA flow diagram for study selection process. Animal studies (Smith et al, 2014a) USA Dried plum (P.…”

Section: Resultsmentioning

confidence: 99%

“…Among these, the study by Smith et al (2014a) is slightly different in that unlike the other studies that studied longer term effects of dried plum on systemic biochemical markers of bone metabolism and alteration in gene expression as the main outcome measure, their main objective was to understand the mechanism of action by which dried plum altered bone metabolism. Regulators of osteoblast and osteoclast differentiation and osteoblast activity were studied over a period of 6 weeks.…”

Section: Bone Healthmentioning

confidence: 98%

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A Systematic Review on the Health Effects of Plums (Prunus domestica and Prunus salicina)

Igwe

Charlton

2016

Phytotherapy Research

100

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In recent times, plums have been described as foods with health-promoting properties. Research on the health effects of plum continue to show promising results on its antiinflammatory, antioxidant and memory-improving characteristics. The increased interest in plum research has been attributed to its high phenolic content, mostly the anthocyanins, which are known to be natural antioxidants. A systematic review of literature was carried out to summarize the available evidence on the impact of plums (Prunus species; domestica and salicina) on disease risk factors and health outcomes. A number of databases were searched according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for relevant studies on plum health effects in vitro, animal studies and clinical trials. A total of 73 relevant peer-reviewed journal articles were included in this review. The level of evidence remains low. Of the 25 human studies, 6 were confirmatory studies of moderate quality, while 19 were exploratory. Plums have been shown to possess antioxidant and antiallergic properties, and consumption is associated with improved cognitive function, bone health parameters and cardiovascular risk factors. Most of the human trials used the dried version of plums rather than fresh fruit, thus limiting translation to dietary messages of the positioning of plums in a healthy diet. Evidence on the health effect of plums has not been extensively studied, and the available evidence needs further confirmation. Copyright © 2016 John Wiley & Sons, Ltd.

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“…The literature search of the PubMed database yielded 50 articles [10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61]. After title/abstract review, 22 articles were screened in full-text and included in this comprehensive review [10,11,12,13,14,15,16,17,18,19,20,21,22,23,…”

Section: Resultsmentioning

confidence: 99%

Dried Plums, Prunes and Bone Health: A Comprehensive Review

Wallace

2017

Nutrients

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The 2015–2020 Dietary Guidelines for Americans advocate for increasing fruit intake and replacing energy-dense foods with those that are nutrient-dense. Nutrition across the lifespan is pivotal for the healthy development and maintenance of bone. The National Osteoporosis Foundation estimates that over half of Americans age 50+ have either osteoporosis or low bone mass. Dried plums, also commonly referred to as prunes, have a unique nutrient and dietary bioactive profile and are suggested to exert beneficial effects on bone. To further elucidate and summarize the potential mechanisms and effects of dried plums on bone health, a comprehensive review of the scientific literature was conducted. The PubMed database was searched through 24 January 2017 for all cell, animal, population and clinical studies that examined the effects of dried plums and/or extracts of the former on markers of bone health. Twenty-four studies were included in the review and summarized in table form. The beneficial effects of dried plums on bone health may be in part due to the variety of phenolics present in the fruit. Animal and cell studies suggest that dried plums and/or their extracts enhance bone formation and inhibit bone resorption through their actions on cell signaling pathways that influence osteoblast and osteoclast differentiation. These studies are consistent with clinical studies that show that dried plums may exert beneficial effects on bone mineral density (BMD). Long-term prospective cohort studies using fractures and BMD as primary endpoints are needed to confirm the effects of smaller clinical, animal and mechanistic studies. Clinical and prospective cohort studies in men are also needed, since they represent roughly 29% of fractures, and likewise, diverse race and ethnic groups. No adverse effects were noted among any of the studies included in this comprehensive review. While the data are not completely consistent, this review suggests that postmenopausal women may safely consume dried plums as part of their fruit intake recommendations given their potential to have protective effects on bone loss.

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A comparative study of the bone metabolic response to dried plum supplementation and PTH treatment in adult, osteopenic ovariectomized rat

Cited by 53 publications

References 33 publications

Protective effect of salidroside against bone loss via hypoxia-inducible factor-1α pathway-induced angiogenesis

Protective effect of salidroside against bone loss via hypoxia-inducible factor-1α pathway-induced angiogenesis

A Systematic Review on the Health Effects of Plums (Prunus domestica and Prunus salicina)

Dried Plums, Prunes and Bone Health: A Comprehensive Review

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