A Comparative Study of the Biocompatibility of Three Root-end Filling Materials in Rat Connective Tissue

Shahi, Shahriar; Rahimi, Saeed; Lotfi, Mehrdad; Yavari, Hamid Reza; Gaderian, AliReza

doi:10.1016/j.joen.2006.01.014

Cited by 74 publications

(114 citation statements)

References 23 publications

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“…More specifically, implantation of materials in the subcutaneous tissue of small animals like rats is considered a reliable and adequate test to evaluate the biocompatibility of materials (17,18,(21)(22)(23). The material may be introduced in the tissues inside polyethylene tubes (17).…”

Section: Discussionmentioning

confidence: 99%

“…The material may be introduced in the tissues inside polyethylene tubes (17). The use of tubes is recommended because they are not irritant to the tissues (17,18,(22)(23)(24)(25) and prevent material diffusion in the tissues, simulating the clinical conditions of medications applied in the root canal (23).…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, empty tube served as negative control because it is an inert material and allows for the formation of connective tissue in contact with its surface (22)(23)(24)(25). Zinc oxide-eugenol paste served as positive control because it is known as an irritating material for the tissues.…”

Section: Discussionmentioning

confidence: 99%

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Biocompatibility of a Calcium Hydroxide-Propolis Experimental Paste in Rat Subcutaneous Tissue

et al. 2014

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Intracanal medications are fundamental for disinfection of the root canal system and participate in periapical repair, so their biocompatibility is of utmost importance to avoid tissue damage. This study evaluated the biocompatibility of a experimental paste of calcium hydroxide and propolis in the subcutaneous tissue of rats. The study was conducted on 15 male Wistar rats. Two incisions were made on the dorsal region of each animal for introduction of 4 tubes: one tube was empty; one contained zinc oxide-eugenol cement, and the two other tubes were filled with experimental paste. After 7, 14 and 30 days, the animals were euthanized and the specimens were subjected to histotechnical preparation. The hematoxylin and eosin-stained histological sections were analyzed by light microscopy. Scores were established according to the inflammatory process and statistically compared by the Tukey test (α=5%). The analysis of histological sections showed non-significant or mild inflammatory reaction in the connective tissue in contact with the empty tubes in all study periods while the contact of subcutaneous tissue with zinc oxide-eugenol elicited moderate or severe inflammation similarly without significant difference among the study periods. The connective tissue was moderately inflamed at 7 days when contacting the experimental paste, but the inflammatory process was non-significant or mild at 14 and 30 days. The experimental paste was biocompatible with the tissues after 14 days of subcutaneous implantation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Biocompatibility of a Calcium Hydroxide-Propolis Experimental Paste in Rat Subcutaneous Tissue

et al. 2014

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“…Periradicular surgery is commonly considered as the treatment of choice when nonsurgical treatment has failed or if existing restorative or prosthetic treatment would be endangered by orthograde treatment (7). The success of endodontic surgery depends on the regeneration of periodontal attachment apparatus including, cement, periodontal ligament and alveolar bone.…”

Section: Discussionmentioning

confidence: 99%

“…The success of endodontic surgery depends on the regeneration of periodontal attachment apparatus including, cement, periodontal ligament and alveolar bone. For this reason, it is important to seal an exposed resected root with a biomaterial with sealing ability and biocompatibility, which permits regeneration of normal periodontium on outer root surfaces (7). The biocompatibility of MTA in contact with cells and tissues was confirmed and new cementum formation was detected close to MTA (8).…”

Section: Discussionmentioning

confidence: 99%

Comparison of Pro Root Mineral Trioxide Aggregate and Calcium Enriched Mixture Cement Microleakage as Root End Filling Material: An in Vitro Analysis of Dye Penetration

Faramarzi¹,

Vossoghi²,

Shams³

et al. 2015

Avicenna J Dent Res

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Background: Sealing ability is an essential factor for retrograde filling material in successful endodontic apical surgery. The aim of this in vitro study was to evaluate dye microleakage of Mineral Trioxide Aggregate (MTA) and Calcium Enriched Mixture (CEM cement) as root end filling material. Objectives: The aim of this in vitro study was to compare sealing ability of these two root end filling materials using the dye penetration method. Materials and Methods: Eighty-six single rooted teeth were randomly divided into two study (n = 40) groups and two positive and negative control (n = 3) groups. After decoronation closely to the cementum enamel junction, the root canals were shaped by the crown down technique and obturated by gutta-percha and AH26 sealer with the lateral condensation method. Furthermore, 3 mm of root ends were resected and 3 mm root-end cavities were prepared by ultrasonic microsurgical tip. Root-end cavities were filled with each of the mentioned materials. Methylene blue dye was used for determination of dye leakage. Chi-2 analysis and t-test were used to compare groups. Results: The mean apical penetration of dye in the MTA group was 0.94 mm while in the CEM cement group this was 1.17 mm. Eighty percent of the MTA group and 75% of the CEM cement group didn't have any dye leakage. The P level was greater than 0.05 (0.592). Conclusions: There was no significant statistical difference between MTA and CEM cement in sealing ability (P > 0.05).

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Root‐End Fillings Using MTA

Baek

Shin

2014

Mineral Trioxide Aggregate

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A Comparative Study of the Biocompatibility of Three Root-end Filling Materials in Rat Connective Tissue

Cited by 74 publications

References 23 publications

Biocompatibility of a Calcium Hydroxide-Propolis Experimental Paste in Rat Subcutaneous Tissue

Biocompatibility of a Calcium Hydroxide-Propolis Experimental Paste in Rat Subcutaneous Tissue

Comparison of Pro Root Mineral Trioxide Aggregate and Calcium Enriched Mixture Cement Microleakage as Root End Filling Material: An in Vitro Analysis of Dye Penetration

Root‐End Fillings Using MTA

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