A comparative study of the aqueous humour and cerebrospinal fluid in the rabbit

Davson, Hugh

doi:10.1113/jphysiol.1955.sp005341

Cited by 185 publications

(95 citation statements)

References 13 publications

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“…1 (Davson, 1955). The points on the figure represent the values of the ratios obtained during the present study on 16 rabbits previously treated with Diamox.…”

Section: Methodsmentioning

confidence: 91%

“…In control experiments on the different species the procedures were exactly similar, with the omission of Diamox. In rabbits control experiments were unnecessary, the results being compared with those obtained on normal animals of similar weight and breed described earlier (Davson, 1955). 24Na was estimated in a liquid counter of the M6 (20th Century Electronics) type, corrections for resolving time, decay and background being made when necessary.…”

Section: Methodsmentioning

confidence: 99%

“…In control experiments the procedure was exactly the same except that Diamox was omitted. For the study of the sugar distributions the procedure was different, because of the tendency of the concentration of this substance in the plasma to rise as a result of emotional stress or general anaesthesia; therefore, instead of obtaining samples of fluids before and after administration of Diamox, they were taken only 24 hr after the drug was given intravenously, and the values of the distribution-ratios so obtained were compared with values obtained earlier on normal animals (Davson & Duke-Elder, 1948;Davson, 1955).…”

Section: Methodsmentioning

confidence: 99%

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The effect of acetazoleamide on the chemical composition of the aqueous humour and cerebrospinal fluid of some mammalian species and on the rate of turnover of ²⁴na in these fluids

Davson¹,

Luck²

1957

The Journal of Physiology

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100

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The carbonic anhydrase inhibitor, acetazoleamide (Diamox), causes striking and sustained falls in both intraocular (Becker, 1954) and cerebrospinal fluid (Tschirgi, Frost & Taylor, 1954) pressures. The falls in pressure have been ascribed to decreased rates of production of fluid and it has been estimated that the decrease in rate of formation of the ocular fluid must amount to some 65 % of the normal (Becker, 1955;Becker & Constant, 1955); if the rate of drip from the subarachnoid space is any true record of the rate of production of the cerebrospinal fluid, the fall in rate is also of this order (Kister, 1956).It was considered that such large changes in the rates of flow might be reflected in measurable decreases in the rates of turnover of 24Na in the fluids; moreover, since these fluids normally have different concentrations of ions and non-electrolytes from those in a dialysate of plasma, changes in rate of flow, and thus of the average sojourn in their respective cavities, might influence the steady-state distributions between fluids and blood plasma. In the present work, the influence of Diamox on the rates of turnover of 24Na in the two fluids, and on the steady-state distributions of sugar, chloride and bicarbonate between plasma and the fluids, has been examined in several species. Changes in some of these steady-state distributions have been found, and the problem has been discussed as to whether they are consequences of a primary decrease in rate of flow, or primary effects of the drug on the secretory mechanisms involved in the elaboration of the fluids. METHODS Kinetic 8tudie8. The technique employed for rabbits was that described earlier (Davson, 1955), a steady concentration of "Na in the plasma being maintained by continuous intravenous infusion, and the aqueous humour and cerebrospinal fluid being withdrawn at stated times after

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“…1 (Davson, 1955). The points on the figure represent the values of the ratios obtained during the present study on 16 rabbits previously treated with Diamox.…”

Section: Methodsmentioning

confidence: 91%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

The effect of acetazoleamide on the chemical composition of the aqueous humour and cerebrospinal fluid of some mammalian species and on the rate of turnover of ²⁴na in these fluids

Davson¹,

Luck²

1957

The Journal of Physiology

Self Cite

100

View full text Add to dashboard Cite

show abstract

“…2, where the chloride space has also been plotted. The slow drift upwards of the chloride space indicates that the tissue was deteriorating a little, and it is presumably for this reason that the uptake of 2Na goes beyond the normal limit observed in studies in vivo, namely to show a 24Na space of 34 6 % (Davson, 1955). The important point, however, is the rapid and smooth uptake of 131, which contrasts so strongly with its negligible uptake in vivo.…”

Section: Volume Of Blood In Brain Tissuementioning

confidence: 94%

“…The horizontal line indicates the chloride space, so that after 2 hr the system is very far from (Davson, 1955), the rates of penetration of these substances into the cerebrospinal fluid were very slow, as is indicated by Fig. 2, where the chloride space has also been plotted.…”

Section: Volume Of Blood In Brain Tissuementioning

confidence: 97%