A comparative study of two modalities, 4% hydroquinone versus 30% salicylic acid in periorbital hyperpigmentation and assessment of quality of life before and after treatment

Abstract

Background:Periorbital hyperpigmentation (POH) is a common hyperpigmentary problem of the face, which can be psychologically distressing and it can influence an individual's quality of life. However, this condition has received less attention in literature.Aims and Objectives:To study the clinico-etiological features and the effect of two therapeutic modalities on the quality of life in patients of POH before and after treatment.Materials and Methods:Fifty patients attending the outpatient clinic of Dermatology Department, with clinically evident POH were included. All patients were divided randomly into two groups of 25 each and one group was treated with 4% hydroquinone and another group with 30% salicylic acid for 12 weeks. Assessment with visual analog scale (VAS) was done at 4, 6, and 12 weeks, and outcome of the patients was analyzed statistically.Results:Majority of the cases, i.e. 26 (52%) were in the age group of 20–30 years. Females comprised 74% of the study population. On VAS, most of the patients showed mild improvement (10–30%) at 12 weeks of treatment in both the groups. Separately, both the treatments significantly improved the dermatological life quality index of the patients although there was no significant difference found between the two groups.Conclusion:POH is less responsive to standard treatments due to its multifactorial etiology and deposition of melanin in both dermis and epidermis. However, even the mild to moderate improvement in appearance can cause an improvement in the quality of life of the patients.

Efficacy and tolerability of using platelet‐rich plasma versus chemical peeling in periorbital hyperpigmentation

“…Another study compared the effect of topical bleaching agent (4% hydroquinone) and 30% salicylic acid peel for 12 weeks, and studied the effect on the quality of life in POH patients in both groups. The authors found that both modalities significantly improved the dermatological life quality index of the patients with no significant difference found between them …”

“…The authors found that both modalities significantly improved the dermatological life quality index of the patients with no significant difference found between them. 21 Because of its autologous nature, PRP is applied without any serious adverse effects, aside from local injection site reactions like pain or secondary infection, which can be precluded with proper precautions.…”

Periorbital Hyperpigmentation—Dark Circles under the Eyes; Treatment Suggestions and Combining Procedures

“…There are topical, physical, and surgical treatment options. Among topical drugs and methods, sunscreens and peels are widely used [16,17]. Tretinoin, vitamin C, arbutin, and azelaic acid are known to reduce melanin pigmentation [18][19][20][21][22].…”

Update in minimally invasive periorbital rejuvenation with a focus on platelet‐rich plasma: A narrative review

“…Hydroquinone is one of the most commonly used agents for pigmentation reduction in strengths varying from 2% to 6%. In a study performed in Indian patients, 4% hydroquinone was found to be effective and tolerable to treat periorbital hyperpigmentation 9 …”