Org. Biomol. Chem.
 2024
DOI: 10.1039/d3ob01937c
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A comparative study of two aldehyde dehydrogenases from Sphingobium sp.: the substrate spectrum and catalytic mechanism

Siyi Chen,
Jieyu Zhou,
Xiangyuan Gu
et al.

Abstract: SpALDH1 and SpALDH2 from Sphingobium sp. SYK-6 exhibit distinct enzymatic properties. Computational simulation reveals that the different substrate specificity could be attributed to the hydrophobicity of substrate binding pockets.

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