A comparative study of vascular cell adhesion molecule-1 and high-sensitive C-reactive protein in normal and preeclamptic pregnancies

Farzadnia, Mehdi; Ayatollahi, Hossein; Hasan-Zade, Maliheh; Rahimi, Hamid Reza

doi:10.1556/imas.5.2013.1.5

Cited by 8 publications

(10 citation statements)

References 40 publications

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“…Redman et al initially proposed that the features of the systemic inflammatory response observed in normotensive pregnant women are also seen in PE women, but in a greater intensity [ 5 ]. Accordingly, several studies have described increased activation of circulating leukocytes, abnormal immune cell phenotype and higher pro-inflammatory markers levels, such as C-reactive protein (CRP), in PE compared to normotensive pregnancy [ 6 – 10 ].…”

Section: Introductionmentioning

confidence: 99%

Annexin A1 Is Increased in the Plasma of Preeclamptic Women

et al. 2015

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BackgroundPreeclampsia (PE) is a pregnancy disease associated with exacerbated inflammatory response. Annexin A1 (AnxA1) is a glucocorticoid-regulated protein endowed with anti-inflammatory and proresolving properties that has been much studied in various animal models of inflammation but poorly studied in the context of human inflammatory diseases. The main objective of this study was to measure AnxA1 levels in PE women and to compare those levels in normotensive pregnant and non-pregnant women. We evaluated the association among AnxA1, ultrasensitive C reactive protein (us-CRP) and soluble tumor necrosis factor alpha receptor type 1 (sTNF-R1) plasma levels of the study participants.MethodsThis study included 40 non-pregnant, 38 normotensive pregnant and 51 PE women. PE women were stratified in early (N = 23) and late (N = 28) subgroups, according to gestational age (GA) at onset of clinical symptoms. Protein AnxA1 and us-CRP plasma levels were determined by ELISA and immunoturbidimetric assays, respectively. Transcript levels of AnxA1 in peripheral blood mononuclear cells (PBMC) were measured by real time RT-PCR.ResultsIncreased levels of AnxA1 coincided with higher us-CRP levels in the plasma of PE women. Pregnant women with early PE had higher levels of AnxA1 and us-CRP than normotensive pregnant women with GA <34 weeks. No significant difference was found for AnxA1 and us-CRP, comparing late PE and normotensive pregnant women with GA ≥34 weeks. AnxA1 mRNA levels in PBMC were similar among the studied groups. AnxA1 was positively correlated with sTNF-R1, but not with us-CRP.ConclusionsOur data show that increased AnxA1 levels were associated with a systemic inflammatory phenotype in PE, suggesting AnxA1 deregulation in PE pathogenesis. However, more studies are needed to clarify the role of AnxA1 and other proresolving molecules in the context of the systemic inflammatory response in this intriguing disease.

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Section: Introductionmentioning

confidence: 99%

Annexin A1 Is Increased in the Plasma of Preeclamptic Women

et al. 2015

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“…According to some studies, the serum levels of two inflammatory markers (namely, sICAM-1 and sVCAM-1) in women with a history of preeclampsia have been elevated (25). Previous studies conducted by the current research team showed that the level of this factor was significantly higher in patients with severe preeclampsia than patients with mild preeclampsia and normal pregnant women (17,18). It seems that these two inflammatory markers indicate preeclampsia-induced endothelial dysfunction in previous pregnancies.…”

Section: Immune System and Preeclampsiamentioning

confidence: 67%

“…Findings showed that the patient with severe preeclampsia had far higher levels of hs-CRP than patients with mild preeclampsia and normal pregnant women, indicating a significant between-groups difference. This implies that preeclampsia is an inflammatory trend that severely stimulates the immune system (17,18). Studies also show that the injection of TNF-α to pregnant mice increases blood pressure (19); in addition, TNF-α has a role in regulated transcription of platelet-derived growth factor (PDGF) and endothelin 1 (ET-1).…”

Section: Immune System and Preeclampsiamentioning

confidence: 99%

Relationship Among Pathophysiology of Gestational Diabetes, Preeclampsia, Vitamin D Level, and Immunomodulation: A Narrative Review

Mohiti¹,

Tara²,

Rahimi³

2016

Acta Healthmedica

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Context: Preeclampsia is among the major causes of maternal, fetal, and neonatal morbidity and mortality, worldwide. It is characterized by an increase in blood pressure and proteinuria (Systolic BP≥140 or Diastolic BP ≥90 mmHg). The serum level of 25-hydroxy vitamin D deficiency has long been suspected as a risk factor for gestational diabetes mellitus (GDM) and preeclampsia, and perhaps 1, 25-dihydroxy vitamin D has a role in the regulation of the immune system. Inflammatory markers, including cytokines, angiogenic factors, leukocytes, interleukins, and acute phase reactants, are involved in the pathophysiology of preeclampsia and gestational diabetes mellitus. Objective: This review article was performed with the aim to assess the relationship among pathophysiology of gestational diabetes, preeclampsia, vitamin D level, and immunomodulation. Evidence Acquisition: Databases of Cochrane (2000Cochrane ( -2016, Embase (2000Embase ( -2016, Pubmed/Medline (1995-2016, and Google Scholar (2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016) were searched to find the related references with keywords of gestational diabetes mellitus, preeclampsia, vitamin D, regulation of the immune system. The contents of the articles were exactly and repeatedly studied and analyzed. Results: Vitamin D deficiency is more prevalent in patients with gestational diabetes mellitus and preeclampsia than normal pregnant women are, so vitamin D supplementation may control glucose levels and blood pressure and improve the outcome of pregnancy. Conclusion: Several studies, materials provided in this study, and clinical evidence confirm that both preeclampsia and gestational diabetes unbalance the maternal immune system; in addition, evidence from casecontrol studies show that vitamin D levels are significantly lower in patients with preeclampsia and diabetes than normal people.

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“…In contrast, other studies report no significant changes in CRP levels between normotensive and pre‐eclamptic women 20,22 . Reports also indicate elevated hs‐CRP level in severe PE cases as compared to mild cases 31,34–36,10 . Majority of the studies indicate that hs‐CRP could be used as a marker for the detection of PE and suggest that hs‐CRP may be utilized as a significant indicator of severity of PE at third‐trimester pregnancy (30–39 weeks) 16,17,29,37 .…”

Section: Discussionmentioning

confidence: 99%

Longitudinal profile of high‐sensitivity C‐reactive protein in women with pre‐eclampsia

Dangat

Wadhwani

Randhir

et al. 2023

American J Rep Immunol

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Problem: C-reactive protein (CRP) is a marker for inflammation and its role as a possible biomarker for an early prediction of pre-eclampsia (PE) is unclear. The present study investigates the levels of high-sensitivity CRP (hs-CRP) longitudinally across pregnancy in women with PE and compares them to women without PE (non-PE). Method of Study: A total of 324 pregnant women [216 non-PE and 108 PE women]were included in this study. Maternal blood was taken at four different intervals (V1 = 11-14 weeks, V2 = 18-22 weeks, V3 = 26-28 weeks, and V4 = at delivery).Results: Maternal serum hs-CRP levels were higher at V1, V2, and V3 (p < .05 for all) in the PE group compared to the non-PE group. The hs-CRP levels were associated with maternal blood pressure throughout pregnancy. Maternal hs-CRP levels did not differ among early and late onset PE. Higher maternal hs-CRP levels were associated with the increased risk of PE in unadjusted model in early pregnancy. However, there was no significance after adjusting for confounding factors. Conclusions:Our findings suggest although the levels of hs-CRP were higher in PE in early pregnancy, they are not associated with an increased risk of PE.

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A comparative study of vascular cell adhesion molecule-1 and high-sensitive C-reactive protein in normal and preeclamptic pregnancies

Cited by 8 publications

References 40 publications

Annexin A1 Is Increased in the Plasma of Preeclamptic Women

Annexin A1 Is Increased in the Plasma of Preeclamptic Women

Relationship Among Pathophysiology of Gestational Diabetes, Preeclampsia, Vitamin D Level, and Immunomodulation: A Narrative Review

Longitudinal profile of high‐sensitivity C‐reactive protein in women with pre‐eclampsia

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