A comparison between amblyopic and fellow eyes in unilateral amblyopia using spectral-domain optical coherence tomography

Araki, Syunsuke; Miki, Atsushi; Yamashita, Tsutomu; Goto, Katsutoshi; Haruishi, Kazuko; Ieki, Yoshiaki; Kiryu, Junichi

doi:10.2147/opth.s69501

Cited by 23 publications

(23 citation statements)

References 39 publications

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“…Our study also compared optic disc structures (disc area, cup area, and horizontal-vertical cup/disc ratios) but failed to find a significant difference between amblyopic and fellow eyes. These results counter the data of Araki et al [ 30 ], who found a significantly larger rim area and smaller cup/disc ratios (average, vertical, and horizontal) in amblyopic eyes. This might have been because their study population included strabismic, anisometropic, and mixed-type amblyopic eyes.…”

Section: Discussioncontrasting

confidence: 95%

Retinal Nerve Fibre Layer and Macular Thicknesses in Adults with Hyperopic Anisometropic Amblyopia

Yakar

Kan

Alan

et al. 2015

Journal of Ophthalmology

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Objectives. This study compared the macular and retinal nerve fibre layer (RNFL) thicknesses and optic nerves of eyes with reduced vision due to anisometropia with the contralateral healthy eyes in adults using optical coherence tomography (OCT). Methods. This cross-sectional study was conducted in Atatürk State Hospital, Sinop, Turkey. Macular and RNFL thicknesses, optic nerve disc area, cup area, and horizontal and vertical cup-to-disc ratios obtained using a NIDEK RS-3000 SLO spectral domain OCT device were compared between the amblyopic and fellow eyes in 30 adults with anisometropic amblyopia 18–55 years old who were seen in our clinic with unilateral poor vision. Results. The mean macular thickness was 266.90 ± 23.22 µm in the amblyopic eyes and 263.90 ± 22.84 µm in the fellow eyes, and the mean RNFL thickness was 111.90 ± 12.9 and 109.70 ± 9.42 µm, respectively. The two thicknesses did not differ significantly between the amblyopic and fellow eyes. There were also no significant differences between the eyes in disc area, cup area, and horizontal-vertical cup/disc ratios. Conclusion. There does not seem to be a difference in macular thickness, peripapillary RNFL, or optic disc structures between the amblyopic and fellow eyes in adults.

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Section: Discussioncontrasting

confidence: 95%

Retinal Nerve Fibre Layer and Macular Thicknesses in Adults with Hyperopic Anisometropic Amblyopia

Yakar

Kan

Alan

et al. 2015

Journal of Ophthalmology

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“…We thought that the adjustment of AL by SE might lead to statistically accurate results. This was in disagreement with Araki et al; 52 they reported a significant correlation between the AL and CMT changes, which might be owing to the relatively small sample size (21 subjects with less difference in the mean SE among the study subjects). By contrast, Kok et al 53 concluded consistent results with our findings; they did not find an abnormal relation between the AL and CMT in amblyopic eyes.…”

Section: Discussioncontrasting

confidence: 74%

Changes in macular parameters in different types of amblyopia: optical coherence tomography study

Kasem¹,

Badawi²

2017

OPTH

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PurposeThe purposes of this study were to investigate the changes in macular parameters (thickness, volume) and peripapillary retinal nerve fiber layer (RNFL) thickness (RNFLT) in different cases of amblyopia versus the normal fellow eyes using optical coherence tomography (OCT) and to estimate the relationship of OCT changes with various defined patients’ parameters.DesignThis is a prospective, observational, cross-sectional case series.MethodsThe method involved measuring the peripapillary RNFLT, macular thickness, and macular volume via spectral domain (OCT) in different types of amblyopia and comparing with the other fellow eyes. This study was conducted at the Mansoura Ophthalmic Center.ResultsA total of 64 patients with different types of amblyopia were included. The mean central macular thickness (CMT) was 196.2±50.03 µm in the amblyopic eyes versus 167±12.76 µm in the fellow eyes (P=0.000), the mean average macular thickness was 265.80±12.77 µm in the amblyopic eyes versus 259.10±3.09 µm in the fellow eyes (P=0.000), the mean macular volume was 7.59±0.32 mm3 in the amblyopic eyes versus 7.34±0.071 mm3 in the fellow eyes (P=0.002), and the mean global RNFLT was 97.00±11.60 µm in the amblyopic eyes versus 78.50±13.05 µm in the fellow eyes (P=0.029). There was a discrepancy between the different amblyopic types. Age and the axial length were the only independent variables that statistically significantly correlated with the CMT.ConclusionThe unilateral amblyopic eyes were prone to have a higher CMT and thicker global RNFL compared to those of the sound fellow eyes. Retinal variations between different types of the amblyopia differ from one type to another. The age could be considered as a predictor of the disease worsening and treatment prognosis. Further studies are required to emphasize these results.

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“…Previous studies that used SD-OCT to evaluate the inner retinal thickness reported finding no significant differences in the GCL+IPL or GCC thicknesses between the amblyopic eyes and the fellow and normal control eyes [ 16 , 27 – 29 ]. In contrast, Park et al [ 30 ] reported that the GCL+IPL thickness was thinner in amblyopic eyes versus the fellow eyes.…”

Section: Discussionmentioning

confidence: 99%

Macular retinal and choroidal thickness in unilateral amblyopia using swept-source optical coherence tomography

et al. 2017

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BackgroundTo investigate macular retinal and choroidal thickness in amblyopic eyes compared to that in fellow and normal eyes using swept-source optical coherence tomography (SS-OCT).MethodsThis study examined 31 patients with hyperopic anisometropic amblyopia (6.9 ± 3.8 years, mean ± standard deviation), 15 patients with strabismic amblyopia without anisometropia (7.9 ± 4.2 years), and 24 age-matched controls (7.8 ± 3.3 years). Retinal and choroidal thickness was measured by 3D scans using SS-OCT. A 6-mm area around the fovea was automatically analyzed using the Early Treatment Diabetic Retinopathy Study map. The thickness from SS-OCT was corrected for magnification error using individual axial length, spherical refraction, cylinder refraction, and corneal radius. Retinal thickness was divided into the macular retinal nerve fiber layer (mRNFL), ganglion cell layer + inner plexiform layer (GCL+IPL), ganglion cell complex (GCC), and the inner limiting membrane to the retinal pigment epithelium (ILM-RPE) thickness. Retinal and choroidal thickness was compared among amblyopic, fellow, and normal eyes.ResultsIn both amblyopia groups, there was no significant difference in the mRNFL, GCL+IPL, and GCC thicknesses among the amblyopic, fellow, and control eyes. In the anisometropic amblyopia group, choroidal thickness (subfovea, center 1 mm, nasal and inferior of the inner ring, nasal of the outer ring, and center 6 mm) of amblyopic eyes were significantly greater than that of fellow and normal eyes. In contrast, none of the choroidal thicknesses were significantly different among the investigated eyes in the strabismic amblyopia group.ConclusionsWe found no significant difference in inner retinal thickness in patients with unilateral amblyopia. Although there were significant differences in choroidal thickness with hyperopic anisometropic amblyopia, there was no significant difference for the strabismic amblyopia. The discrepancy in choroidal thickness between the two types of amblyopia may be due to both differences in ocular size and underlying mechanism.

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A comparison between amblyopic and fellow eyes in unilateral amblyopia using spectral-domain optical coherence tomography

Cited by 23 publications

References 39 publications

Retinal Nerve Fibre Layer and Macular Thicknesses in Adults with Hyperopic Anisometropic Amblyopia

Retinal Nerve Fibre Layer and Macular Thicknesses in Adults with Hyperopic Anisometropic Amblyopia

Changes in macular parameters in different types of amblyopia: optical coherence tomography study

Macular retinal and choroidal thickness in unilateral amblyopia using swept-source optical coherence tomography

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